DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp20-33 and Usp16

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_006248077.1	Gene:	Usp16 / 288306	RGDID:	1307192	Length:	826	Species:	Rattus norvegicus

Alignment Length:	720	Identity:	147/720 - (20%)
Similarity:	245/720 - (34%)	Gaps:	221/720 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LSSNP-NPHNPYVEHRNRTIHSSQGHTLANGYAMGDPRSSRCHDKLFSGSLKSLARREDSNASDS 66
            ::|.| ..:|.::|..|:.:....                           |:...||.|.:...
  Rat   144 ITSKPAEKNNGHIELENKKLEKES---------------------------KNEQEREKSESMAK 181

  Fly    67 EGTDTAKGSGTGLVGLQNIANTCYMNSALQALSNLPPMTHYF--INCSDLVEYIAEQSARRCK-- 127
            |.......|...:.||.|:.|||:.|:.:|.||..|.:....  :..|..:..|........:
  Rat   182 ENIPLDSASQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLALTEPL 246

  Fly   128 ------PGGLAKSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMD 186
                  ||.|..:..:.:.|:   .::.|..:.|:.:...:......|:||||.|:||.||..:|
  Rat   247 EVNLEPPGPLTLAMSQFLNEM---QENKKRIVTPKELFSQVCKKATRFKGYQQQDSQELLRYLLD 308

  Fly   187 QLHEELTEQVS--MLPQTQNQPQYQSLQQQQPSETDDENDDEAAPA------------------- 230
            .:..|..::||  :|....|..  :.|.::..::..|....:|.|:
  Rat   309 GMRAEEHQRVSKGILKAFGNST--EKLDEEVKNKVKDYEKKKAIPSFVDRIFGGELTSTIMCDDC 371

  Fly   231 ---SLSHAS--------------------------------ESEYDTCESSMSERS--------- 251
               ||.|.|                                :||.:..:|.|..||
  Rat   372 RTVSLVHESFLDLSLPVLDDQSGKKNINDKNVKKTMEEEDKDSEEEKDDSYMKTRSDVPSGTSKH 436

  Fly   252 --------AEVLLKTE-----------YFVTPCRTN-------GSNSGLP----------EGHSV 280
                    |:...|.:           :|...|.||       .:.:.||          .|...
  Rat   437 TQKKAKKQAKKQAKNQRRQQKIQERFLHFNEICTTNYTEDNDHEAETALPGEGEVDTEFNRGSQE 501

  Fly   281 QLQQAPLQHQQKNASSAEQKPIEAA------------RSIISDVFDGKLLSSVQC-LTCDRVSTR 332
            :|.|..|...||:.:..|:. ||:|            :|:.::...|.|.|:.:| ...:.....
  Rat   502 ELTQTELCANQKDVNGQEEM-IESAADERKCPEHPEVKSVSTESDLGSLTSAPECPRDLNGAFLE 565

  Fly   333 EETFQDLSLP------------IPNRDFLNVLHQTHSLSVQSLNAAETSARTNEGWLSWMWNMLR 385
            |.|..:|.:.            .|:...:.:|:.:||   .:|...|......|.....:.|  |
  Rat   566 ERTSGELDITNGLKNLTLNAAVDPDEISIEILNDSHS---PALKVYEVMNEDPETAFCTLAN--R 625

  Fly   386 SWIYGPSVTLYDCMASFFSADELKGDNMYSCE-----RCNKLRTGIKYSR------------VLT 433
            ........::..|:..|...::|:..|...||     :||..:..||..|            |..
  Rat   626 EAFSTDECSIQHCLYQFTRNEKLQDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLVSL 690

  Fly   434 LPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHKDCK-----SEVAIYNLSSVICHHG 493
            .|.||.:|||||:.......|::..:.|| |..|:.|:....||     |...:|:|..|:.|.|
  Rat   691 APPVLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEESTRVLYSLYGVVEHSG 754

  Fly   494 TVGGGHYTCFAR-----------------------NTLNGKWYEFDDQFVTEVSSELVQSCQAYV 535
            |:..||||.:|:                       .:..|:|:...|..|..|....|.:.|||:
  Rat   755 TMRSGHYTAYAKERTASCHLSNLVLHGDIPQDCEMESTKGQWFHISDTHVQAVPITKVLNSQAYL 819

  Fly   536 LFYHK 540
            |||.:
  Rat   820 LFYER 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	134/639 (21%)
		Peptidase_C19	80..>204	CDD:271592	34/135 (25%)
		Peptidase_C19R	307..538	CDD:239139	67/288 (23%)
		DUSP	560..643	CDD:197831
		DUSP	667..755	CDD:197831
Usp16	XP_006248077.1	zf-UBP	48..122	CDD:280334
		Peptidase_C19K	196..>401	CDD:239132	43/209 (21%)
		UCH	196..>393	CDD:278850	43/201 (21%)
		Peptidase_C19K	<625..823	CDD:239132	52/198 (26%)
		UCH	<634..822	CDD:278850	50/188 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900