Protein Alignment Usp20-33 and USP49

DIOPT Version :10

• Sequence 1: NP_610943.2
• Gene: Usp20-33 / 36580
• FlyBaseID: FBgn0033916
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_001273483.1
• Gene: USP49 / 25862
• HGNCID: 20078
• Length: 688
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 128/543 - (23%)
• Similarity: 189/543 - (34%)
• Gaps: 209/543 - (38%)

  Fly    78 GLVGLQNIANTCYMNSALQALSNLPPMTHYFINC-------------------------SDLVEY 117
            |:.||:|:.|||||||.||.||:|......|:|.                         |...|.
Human   251 GVTGLRNLGNTCYMNSILQVLSHLQKFRECFLNLDPSKTEHLFPKATNGKTQLSGKPTNSSATEL 315

  Fly   118 -IAEQSARRCKPGG---------------------------LAKSYRRLMQEIWQDVDDPKEFIA 154
             :....|..|:..|                           |.:....|.:.:|   ......::
Human   316 SLRNDRAEACEREGFCWNGRASISRSLELIQNKEPSSKHISLCRELHTLFRVMW---SGKWALVS 377

  Fly   155 PRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTEQVSMLPQTQNQPQYQSLQQQQPSET 219
            |..:|:.:.::.|.||||.|.|.||||...:.::.:||
Human   378 PFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL--------------------------- 415

  Fly   220 DDENDDEAAPASLSHASESEYDTCESSMSERSAEVLLKTEYFVTPCRTNGSNSGLPEGHSVQLQQ 284
                             |||..|         ..:|:
Human   416 -----------------ESEGTT---------RRILI---------------------------- 426

  Fly   285 APLQHQQKNASSAEQKPIEAARSIISDVFDGKLLSSVQCLTCDRVSTREETFQDLSLPIPNR--- 346
             |.         :::|..:....:::.:|.|:|||.|.|::|:..|...|.|.||||..|.|
Human   427 -PF---------SQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHC 481

  Fly   347 ---DFLNVLHQTHSLSVQSLNAAETSARTNEGWLSWMWNMLRSWIYGPSVTLYDCMASFFSADEL 408
               .|: .|:||..|                                    |.:.:|.|...:.|
Human   482 IEKGFV-PLNQTECL------------------------------------LTEMLAKFTETEAL 509

  Fly   409 KGDNMYSCERCNK-----------LRTGIKYSRVLTLPEVLCIHLKRFR-NDLSYSSKISSDVYF 461
            :| .:|:|::||.           |....|...:..||:||.:|||||| :..::..||...|.|
Human   510 EG-RIYACDQCNSKRRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVF 573

  Fly   462 PLEGFDMRPYIHKDCKS----EVAIYNLSSVICHHGT-VGGGHYTCFARNTLNGKWYEFDDQFVT 521
            . :...|.||..:|..|    |...|:||:|:.|||. .|.||||.:..||..|.|...:|..:.
Human   574 D-QVLTMEPYCCRDMLSSLDKETFAYDLSAVVMHHGKGFGSGHYTAYCYNTEGGFWVHCNDSKLN 637

  Fly   522 EVSSELVQSCQAYVLFYHKHNPQ 544
            ..|.|.|...|||:|||.:...|
Human   638 VCSVEEVCKTQAYILFYTQRTVQ 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	80..538	CDD:425685	124/533 (23%)
		DUSP	560..643	CDD:197831
		DUSP	667..755	CDD:197831
USP49	NP_001273483.1	zf-UBP	26..87	CDD:460464
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..230
		UCH	253..654	CDD:425685	124/533 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..315		1/21 (5%)