DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Usp20-33 and USP33

DIOPT Version :9

Sequence 1:NP_610943.2 Gene:Usp20-33 / 36580 FlyBaseID:FBgn0033916 Length:975 Species:Drosophila melanogaster
Sequence 2:NP_055832.3 Gene:USP33 / 23032 HGNCID:20059 Length:942 Species:Homo sapiens


Alignment Length:786 Identity:323/786 - (41%)
Similarity:442/786 - (56%) Gaps:105/786 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 DSEGTDTAKGSGTGLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIAEQSARRCKPG 129
            |.|..:..:....||.||:||.||||||:|||||||.||:|.:|::|..|        ||..|..
Human   170 DIEADEEDELRARGLTGLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGL--------ARTDKKP 226

  Fly   130 GLAKSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTE 194
            .:.|||.:||.|:|.. ..|.. :.|..:..||:||:|.||||.|.|.||||||.||.|||||.|
Human   227 AICKSYLKLMTELWHK-SRPGS-VVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKE 289

  Fly   195 QVSML---PQT------------QNQPQYQSLQ-----------------QQQPSET-----DDE 222
            ||..:   |||            |:...:||.:                 .:..:||     |||
Human   290 QVMEVEEDPQTITTEETMEEDKSQSDVDFQSCESCSNSDRAENENGSRCFSEDNNETTMLIQDDE 354

  Fly   223 NDDEAAPASLSHA---------SESEYDTCESSMSER---------SAEVLLKTEYFVTPCRTNG 269
            |:.|.:.......         ||.|:|....|:||.         ..::..:...::|...:|.
Human   355 NNSEMSKDWQKEKMCNKINKVNSEGEFDKDRDSISETVDLNNQETVKVQIHSRASEYITDVHSND 419

  Fly   270 --------SNSGL--------PEGHSVQLQQAPLQHQQKNASSAEQKPIEAARSIISDVFDGKLL 318
                    ||.|:        |:..::....||...:.::||...:|..:..||:|||:|||.::
Human   420 LSTPQILPSNEGVNPRLSASPPKSGNLWPGLAPPHKKAQSASPKRKKQHKKYRSVISDIFDGTII 484

  Fly   319 SSVQCLTCDRVSTREETFQDLSLPIPNRDFLNVLH-QTHSLSVQSLNAAETSARTNEGWLSWMWN 382
            ||||||||||||...|||||||||||.::.|..|| .:|..|:....:. ..|...:||:::...
Human   485 SSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLHSSSHPTSIVKAGSC-GEAYAPQGWIAFFME 548

  Fly   383 MLR--------SWIYGPSVTLYDCMASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLPEVLC 439
            .::        ||.:||.|||.||:|:||:.||||||||||||:|.|||.|:|:.:|...||:||
Human   549 YVKRFVVSCVPSWFWGPVVTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILC 613

  Fly   440 IHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHKDCKSEVAIYNLSSVICHHGTVGGGHYTCFA 504
            |||||||::|.:|:|||:.|.|||||.|::|::.||..:::..|:|.||||||||...|||..:.
Human   614 IHLKRFRHELMFSTKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYC 678

  Fly   505 RNTLNGKWYEFDDQFVTEVSSELVQSCQAYVLFYHKHNPQ-MKLVRDEAMTLSTSHPLCDSDIQF 568
            ||.||..|||||||.|||||...||:.:||||||.|.:.: .|..|..:..|:...|   |.:||
Human   679 RNNLNNLWYEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIMEP---SLLQF 740

  Fly   569 YITREWLSRLATFSEPGPINNQEMLCPHGGILHSKADVISQIAVPISQPLWDYLYRTFGGGPAVN 633
            ||:|:||::..||:|||||:|.:.||.|||:...||..|..:.:.:.|.:||.||..:|||||||
Human   741 YISRQWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAVN 805

  Fly   634 IIFECEICKRAAETLSRRQQYELNEFTKYN-GLQNEFDSTAIYAIAMPWLRSWQQFSRGKTHKDP 697
            .::.|..|:..||.:.:|::.||..|.:.| ..|.|......|.|:|.|.|.|:.|.:||....|
Human   806 HLYICHTCQIEAEKIEKRRKTELEIFIRLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPP 870

  Fly   698 GPITNEGIAAPTENGSATVSCVRLGSDYAQLNARLWRFLHNIYGGGPEIILRQALSDED----DA 758
            |||.|..||. |:.|:.   .:|.|:|..|::...|.||.:|||||||:|||..:...|    .|
Human   871 GPIDNTKIAV-TKCGNV---MLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVDPDILQA 931

  Fly   759 EE-IEI 763
            || ||:
Human   932 EEKIEV 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Usp20-33NP_610943.2 UCH 79..538 CDD:278850 225/538 (42%)
Peptidase_C19 80..>204 CDD:271592 65/138 (47%)
Peptidase_C19R 307..538 CDD:239139 130/239 (54%)
DUSP 560..643 CDD:197831 39/82 (48%)
DUSP 667..755 CDD:197831 36/87 (41%)
USP33NP_055832.3 zf-UBP 61..121 CDD:280334
UCH 184..712 CDD:278850 225/538 (42%)
Peptidase_C19 186..>288 CDD:271592 58/111 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..357 12/62 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..469 9/49 (18%)
Peptidase_C19R 473..713 CDD:239139 131/240 (55%)
DUSP 734..803 CDD:299905 33/71 (46%)
DUSP 840..924 CDD:197831 36/87 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 400 1.000 Domainoid score I739
eggNOG 1 0.900 - - E1_COG5560
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 577 1.000 Inparanoid score I1036
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46045
OrthoDB 1 1.010 - - D147564at2759
OrthoFinder 1 1.000 - - FOG0003021
OrthoInspector 1 1.000 - - otm41730
orthoMCL 1 0.900 - - OOG6_103732
Panther 1 1.100 - - O PTHR21646
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2011
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.840

Return to query results.
Submit another query.