DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp20-33 and Usp15

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_006241493.1	Gene:	Usp15 / 171329	RGDID:	628795	Length:	981	Species:	Rattus norvegicus

Alignment Length:	765	Identity:	171/765 - (22%)
Similarity:	253/765 - (33%)	Gaps:	299/765 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLSSNPNPHNPYVEHRNRTIHSSQ----GHTLANGYAMGDPRSSRCHDKLFSGSLKSLARREDSN 62
            |||:|.|..|      ||.:.:|.    .:|....|...:|                 .|..:.
  Rat   245 SLSNNYNNIN------NRNVKNSNYCLPSYTAYKNYDYSEP-----------------GRNNEQ- 285

  Fly    63 ASDSEGTDTAKGSGTGLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIAEQSARRCK 127
                          .||.||.|:.|||:||||:|.|||.||:|.||:|    .:|  ::......
  Rat   286 --------------PGLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLN----DKY--QEELNFDN 330

  Fly   128 P----GGLAKSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQL 188
            |    |.:||||..|::::|   .....::.||.....:....|.|.||||.|.||.|...:|.|
  Rat   331 PLGMRGEIAKSYAELIKQMW---SGKFSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGL 392

  Fly   189 HEELT----EQVSMLPQTQNQPQYQSLQQQQPSETDDENDD------------------EAAPAS 231
            ||:|.    :....|.....:|  ..:..::..|...:.:|                  |.|..|
  Rat   393 HEDLNRIRKKPYIQLKDADGRP--DKVVAEEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKIS 455

  Fly   232 LSH----------------------------ASESEY-----------DTCES------------ 245
            ::.                            |...:|           |.|.:
  Rat   456 VTFDPFCYLTLPLPMKKERSLEVYLVRMDPLAKPMQYKVIVPKIGNILDLCTALSALSGVPADKM 520

  Fly   246 --------------SMSERSAEVLLK---------------TEYFVTP----------------- 264
                          :|.|..:.::.:               ||:.|.|
  Rat   521 IVTDIYNHRFHRIFAMDENLSSIMERDDIYVFEININRTEDTEHVVIPVCLREKFRHSSYTHHTG 585

  Fly   265 -----------------------------CR------------------------TNGSNSGLPE 276
                                         ||                        .||.|....|
  Rat   586 SSLFGQPFLMAVPRNNTEDKLYNLLLLRMCRYVKMSTETEETDGPLRCCEDQNINGNGPNGIHEE 650

  Fly   277 GHSVQLQQAPLQHQQKNASSAEQK-PIEAARSIISDVFDGK------LLSSVQC----------- 323
            |...:::    ..:..:.||.:|: |.|...|...|...|.      |.:...|
  Rat   651 GSPSEME----TDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTEETCKGQLTGHKKRL 711

  Fly   324 ------------LTCDRVSTREETFQDLSLPIPNRDFLNVLHQTHSLSVQSL--NAAETSARTNE 374
                        :...:..||...|.|..|.:..|.|| .|.....|..:..  ||||.
  Rat   712 FTFQFNNLGNTDINYIKDDTRHIRFDDRQLRLDERSFL-ALDWDPDLKKRYFDENAAED------ 769

  Fly   375 GWLSWMWNMLRSWIYGPS----VTLYDCMASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLP 435
                  :....|..|.|.    |.|.||:..|.:.::|..::.:.|..|.:.:...|...:.:||
  Rat   770 ------FEKHESVEYKPPKRPFVKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLP 828

  Fly   436 EVLCIHLKRFRNDLSYS----SKISSDVYFPLEGFDMRPYIHK----DCKSEVAIYNLSSVICHH 492
            .||.:|||||    |||    .|:.:.|.||:...||..::..    .|:     |||.:|..|:
  Rat   829 PVLVVHLKRF----SYSRYMRDKLDTLVDFPISDLDMSEFLINPNAGPCR-----YNLIAVSNHY 884

  Fly   493 GTVGGGHYTCFARNTLNGKWYEFDDQFVTEVSSELVQSCQAYVLFYHKHN 542
            |.:||||||.||:|..:||||.|||..|:..|.:.:.|..||||||.:.:
  Rat   885 GGMGGGHYTAFAKNKDDGKWYYFDDSSVSTASEDQIVSKAAYVLFYQRQD 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	155/678 (23%)
		Peptidase_C19	80..>204	CDD:271592	47/131 (36%)
		Peptidase_C19R	307..538	CDD:239139	79/273 (29%)
		DUSP	560..643	CDD:197831
		DUSP	667..755	CDD:197831
Usp15	XP_006241493.1	UBP12	12..932	CDD:227847	171/761 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810