DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp20-33 and USP43

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_694942.3	Gene:	USP43 / 124739	HGNCID:	20072	Length:	1123	Species:	Homo sapiens

Alignment Length:	1105	Identity:	236/1105 - (21%)
Similarity:	362/1105 - (32%)	Gaps:	386/1105 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GHTLANGYAMGDPRSSRCHDKLFSGSLKSLARREDSNAS-----------DSEG--------TDT 71
            |.....|.....||..|...:|||..|.:|..|.....|           |.||        ...
Human     6 GDAAGGGPLAPRPRRRRSLRRLFSRFLLALGSRSRPGDSPPRPQPGHCDGDGEGGFACAPGPVPA 70

  Fly    72 AKGS----------------------GTGLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDL 114
            |.||                      ..|..||:|..|||:||:.:|.|||           :||
Human    71 APGSPGEERPPGPQPQLQLPAGDGARPPGAQGLKNHGNTCFMNAVVQCLSN-----------TDL 124

  Fly   115 VEYIAEQSARRCKPG--GLAKSYRRLMQEIWQDVDDP------KEFIAPRGILYGIRTVHPMFRG 171
            :.........|..||  .:.:....|::.:|.....|      |..::..|         ..|:|
Human   125 LAEFLALGRYRAAPGRAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYG---------SQFQG 180

  Fly   172 YQQHDTQEFLRCFMDQLHEEL--------TEQV---------------SMLP------QTQNQPQ 207
            ..|||..|||...:|::||:|        :|::               :.||      |:..|.|
Human   181 NSQHDALEFLLWLLDRVHEDLEGSSRGPVSEKLPPEATKTSENCLSPSAQLPLGQSFVQSHFQAQ 245

  Fly   208 YQS-------LQQQQPSETDDENDDEAAPASLSHASESEYDTCESSMSERSAEVLLKTEYFVTPC 265
            |:|       |:|   |.|.|.....:.|..|.............|.|:|...|.|......|..
Human   246 YRSSLTCPHCLKQ---SNTFDPFLCVSLPIPLRQTRFLSVTLVFPSKSQRFLRVGLAVPILSTVA 307

  Fly   266 ---RTNGSNSGLP----------------------------EGHSVQLQQAPLQHQQKNASS--- 296
               :......|:|                            ||.:|...|.|....|...|:
Human   308 ALRKMVAEEGGVPADEVILVELYPSGFQRSFFDEEDLNTIAEGDNVYAFQVPPSPSQGTLSAHPL 372

  Fly   297 -AEQKPIEAAR-------SIISDVFDGKLLSSVQCLTCDRVSTREETF---------QDLSL--- 341
             ....|..|||       |:.|:       |.|..|.|:.|.:.::..         :|.::
Human   373 GLSASPRLAAREGQRFSLSLHSE-------SKVLILFCNLVGSGQQASRFGPPFLIREDRAVSWA 430

  Fly   342 ------------------PIPNRDFLNVLHQTHSLSVQSLNAA--ETSARTNEGWLSWM------ 380
                              |:.|      |....|:.|..|:.|  ..|.:.:.....|.
Human   431 QLQQSILSKVRHLMKSEAPVQN------LGSLFSIRVVGLSVACSYLSPKDSRPLCHWAVDRVLH 489

  Fly   381 ---------------W-NMLRSWIYGP----------------------SVTLYDCMASFFSADE 407
                           | :.::..::|.                      |.||.:|...:...::
Human   490 LRRPGGPPHVKLAVEWDSSVKERLFGSLQEERAQDADSVWQQQQAHQQHSCTLDECFQFYTKEEQ 554

  Fly   408 LKGDNMYSCERCNKLRTGIKYSRVLTLPEVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYI 472
            |..|:.:.|..|..|:.|:....:.|||::|.||||||.......:|:|:.|.|||.|.:|.|::
Human   555 LAQDDAWKCPHCQVLQQGMVKLSLWTLPDILIIHLKRFCQVGERRNKLSTLVKFPLSGLNMAPHV 619

  Fly   473 HKDCKSEVA----------------------IYNLSSVICHHGTVGGGHYTCFARNTLNGKWYEF 515
            .:...|..|                      :|:|.:|..|||.:.|||||.:.||:|:|:||.:
Human   620 AQRSTSPEAGLGPWPSWKQPDCLPTSYPLDFLYDLYAVCNHHGNLQGGHYTAYCRNSLDGQWYSY 684

  Fly   516 DDQFVTEVSSELVQSCQAYVLFYHKHNPQMKLVRDEAMTLSTSHPLCDSDIQFYITREWLSRLAT 580
            ||..|..:..:.|.:..||:|||.|.|.........:|..|||..|.|         .||.||.:
Human   685 DDSTVEPLREDEVNTRGAYILFYQKRNSIPPWSASSSMRGSTSSSLSD---------HWLLRLGS 740

  Fly   581 F------------SEPGP--------------INNQEM--LCPHGGILHSKADVISQIAVPISQ- 616
            .            |.|.|              :.|||.  |.|...:...|...||..|...|:
Human   741 HAGSTRGSLLSWSSAPCPSLPQVPDSPIFTNSLCNQEKGGLEPRRLVRGVKGRSISMKAPTTSRA 805

  Fly   617 --------PL-WDYLYRTFGGGPAVNIIFECEICKRAAETLSRRQQYELNEFTKYNGLQNEFDST 672
                    || |.:..:....|.:|.::...|..:|...|                       |.
Human   806 KQGPFKTMPLRWSFGSKEKPPGASVELVEYLESRRRPRST-----------------------SQ 847

  Fly   673 AIYAIAMPWLRSWQQFSRGKTHKDPGPITNEGIAAPTENGS-------ATVSCVRLGSDYAQLNA 730
            :|.::...        :.|:..|...|.:|..:.|.:|:|.       |.|.|     ..||.|
Human   848 SIVSLLTG--------TAGEDEKSASPRSNVALPANSEDGGRAIERGPAGVPC-----PSAQPN- 898

  Fly   731 RLWRFLHNIYGG---GPEIILRQALSDEDDAEEIEIIDQDD-----ECDDDEDQDLEGEGEDEEI 787
                  |.:..|   ||....:   ..|:..::|::..:.|     ....:.::....||:....
Human   899 ------HCLAPGNSDGPNTARK---LKENAGQDIKLPRKFDLPLTVMPSVEHEKPARPEGQKAMN 954

  Fly   788 AAASYQHNHSDTESNLGIRNTPSPSP----STSPSPSLTGTRQ---PMETESDLRPSSSKSKRSR 845
            ...|:|         :|.:::| |||    |.:...|..||.:   |::....|..|..:.|.:|
Human   955 WKESFQ---------MGSKSSP-PSPYMGFSGNSKDSRRGTSELDRPLQGTLTLLRSVFRKKENR 1009

Fly 846 845
Human 1010 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	142/642 (22%)
		Peptidase_C19	80..>204	CDD:271592	38/160 (24%)
		Peptidase_C19R	307..538	CDD:239139	74/328 (23%)
		DUSP	560..643	CDD:197831	25/120 (21%)
		DUSP	667..755	CDD:197831	19/97 (20%)
USP43	NP_694942.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102		19/95 (20%)
		DUF3628	<36..>107	CDD:289100	12/70 (17%)
		Peptidase_C19	<98..>210	CDD:271592	35/131 (27%)
		Peptidase_C19	102..>284	CDD:271592	49/204 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	202..221		1/18 (6%)
		Peptidase_C19R	<540..708	CDD:239139	55/167 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	795..826		7/30 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..886		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..1049		15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1099
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900