Protein Alignment Usp20-33 and USP18

DIOPT Version :9

• Sequence 1: NP_610943.2
• Gene: Usp20-33 / 36580
• FlyBaseID: FBgn0033916
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_059110.2
• Gene: USP18 / 11274
• HGNCID: 12616
• Length: 372
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 106/504 - (21%)
• Similarity: 166/504 - (32%)
• Gaps: 184/504 - (36%)

  Fly    57 RREDSNASDSEGTDTAKG--SGTGLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIA 119
            :.||||....:..:..:.  ...|||||.||..||.:||.:|.         :.:|.
Human    30 KEEDSNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQV---------FVMNV-------- 77

  Fly   120 EQSARRCKPGGLAKSYRRLMQEIWQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCF 184
                          .:.|::          |....|||
Human    78 --------------DFTRIL----------KRITVPRG--------------------------- 91

  Fly   185 MDQLHEELTEQVSMLPQTQNQPQYQSLQQQQPSETDDENDDEAAPASLSHASESEYDTCESSM-- 247
            .|:....:..|:.:|           |::.|     |.......|..|::..:.    |...:
Human    92 ADEQRRSVPFQMLLL-----------LEKMQ-----DSRQKAVRPLELAYCLQK----CNVPLFV 136

  Fly   248 SERSAEVLLKTEYFVTPCRTNGSNSGLPEGHSVQLQQAPLQHQQKNASSAEQKPIEAARSIISDV 312
            ...:|::.||.        .|.....:.:.|.|:..||                          :
Human   137 QHDAAQLYLKL--------WNLIKDQITDVHLVERLQA--------------------------L 167

  Fly   313 FDGKLLSSVQCLTCDRVSTREETFQDLSLPIPNRDFLNVLHQTHSLSVQSLNAAETSARTNEGWL 377
            :..::..|:.|:.|...|:|..:.  |:||:                  ||...::.
Human   168 YTIRVKDSLICVDCAMESSRNSSM--LTLPL------------------SLFDVDSK-------- 204

  Fly   378 SWMWNMLRSWIYGPSVTLYDCMASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLPEVLCIHL 442
                         |..||.|.:..||...||...:...||.|.|...|.:..::..||:.|.|||
Human   205 -------------PLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHL 256

  Fly   443 KRFRNDLSYSSKISSDVYFP--LEGFDMRPYIHKDCKSEV---AIYNLSSVICHHGTVGGGHYTC 502
            .||....|.:.||...:|||  |:...:.|...:.|.:|.   ..|.|.:||.|.|....|||..
Human   257 MRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCV 321

  Fly   503 FARNTLNGKWYEFDDQFVTEVSSELVQSC-----------QAYVLFYHK 540
            :.||.::|||:.|:|..:..||.|.:| |           .||:|.|.|
Human   322 YIRNAVDGKWFCFNDSNICLVSWEDIQ-CTYGNPNYHWQETAYLLVYMK 369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	99/476 (21%)
		Peptidase_C19	80..>204	CDD:271592	19/123 (15%)
		Peptidase_C19R	307..538	CDD:239139	65/246 (26%)
		DUSP	560..643	CDD:197831
		DUSP	667..755	CDD:197831
USP18	NP_059110.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..45		4/14 (29%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510	36..51		0/14 (0%)
		Mediates interaction with STAT2. /evidence=ECO:0000269|PubMed:28165510	51..112		23/144 (16%)
		UCH	55..367	CDD:306860	98/475 (21%)
		Mediates interaction with STAT2 and necessary for the negative regulation of the type I IFN signaling pathway. /evidence=ECO:0000269|PubMed:28165510	303..312		4/8 (50%)
		Mediates interaction with IFNAR2. /evidence=ECO:0000269|PubMed:28165510	313..372		20/58 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147564at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920