DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp20-33 and USP19

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_005264880.1	Gene:	USP19 / 10869	HGNCID:	12617	Length:	1423	Species:	Homo sapiens

Alignment Length:	851	Identity:	166/851 - (19%)
Similarity:	261/851 - (30%)	Gaps:	337/851 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIAEQSARRCKP----GGLAKSYRRL 138
            |..||.|:.|||:|||.:|:|||...:..:|.:.|      .|.......|    |.||..:..|
Human   600 GFTGLVNLGNTCFMNSVIQSLSNTRELRDFFHDRS------FEAEINYNNPLGTGGRLAIGFAVL 658

  Fly   139 MQEIWQDVDDP------KEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTEQVS 197
            ::.:|:.....      |..:|.:.         ..|.||.|||.|||:...:|.|||:| .::.
Human   659 LRALWKGTHHAFQPSKLKAIVASKA---------SQFTGYAQHDAQEFMAFLLDGLHEDL-NRIQ 713

  Fly   198 MLPQTQN-------------------------------QPQYQS--------------------- 210
            ..|.|:.                               |.||:|
Human   714 NKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLP 778

  Fly   211 --LQQQQ-------------------------PSETDDENDDEAAPA------------------ 230
              |.|:|                         .:.|..|..|..:.:
Human   779 VPLPQKQKVLPVFYFAREPHSKPIKFLVSVSKENSTASEVLDSLSQSVHVKPENLRLAEVIKNRF 843

  Fly   231 --------SLSHASESEYDTCESSMSERSAE---VLLKTE------------------------- 259
                    ||...|.|:...|...:|...|:   |:|:.:
Human   844 HRVFLPSHSLDTVSPSDTLLCFELLSSELAKERVVVLEVQQRPQVPSVPISKCAACQRKQQSEDE 908

  Fly   260 --------YFVTPCR--------------TNGSNSGLP-------------------EG---HSV 280
                    |.|..|.              ....|.|.|                   ||   :||
Human   909 KLKRCTRCYRVGYCNQLCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARLAQLLEGYARYSV 973

  Fly   281 QLQQAPLQHQQK------------------NASSAEQKPIEAAR-SIISDVFDG----------- 315
            .:.|.|.|..:.                  .|..:|:.||:... .:::.:.:|
Human   974 SVFQPPFQPGRMALESQSPGCTTLLSTGSLEAGDSERDPIQPPELQLVTPMAEGDTGLPRVWAAP 1038

  Fly   316 -------------KLLSS----VQCLTC-DRVSTREETFQDLSLPIPNRDFLNVLHQTHSLSVQS 362
                         ::|:|    |..|.. :|||..|........|   .:.:|.  .|....:..
Human  1039 DRGPVPSTSGISSEMLASGPIEVGSLPAGERVSRPEAAVPGYQHP---SEAMNA--HTPQFFIYK 1098

  Fly   363 LNAAETSARTNEGW-----------LSWMW---NMLRSWIYGPS--------------------V 393
            ::::....|..:..           |:.:|   ..|:.::...|                    .
Human  1099 IDSSNREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGEAARAGHF 1163

  Fly   394 TLYDCMASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLPEVLCIHLKRFR-NDLSYSSKISS 457
            ||..|:..|...:.|..:..:.|.:|.:.|...|...:..||.||.:.||||. ....:..||:.
Human  1164 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFIWRDKIND 1228

  Fly   458 DVYFPLEGFDMRPYIHKDCKSEVAIYNLSSVICHHGTVGGGHYTCFAR--NTLNGK-----WYEF 515
            .|.||:...|:..:.....:.::..|:|.:||.|:|.:.|||||..||  |..:.:     |..|
Human  1229 LVEFPVRNLDLSKFCIGQKEEQLPSYDLYAVINHYGGMIGGHYTACARLPNDRSSQRSDVGWRLF 1293

  Fly   516 DDQFVTEVSSELVQSCQAYVLFYHKHNPQMKLVRDEAMTLSTSHPLCDSDI-------QFYITRE 573
            ||..||.|....|.:..||||||.:.|..::  |......|..||    |:       ....:|.
Human  1294 DDSTVTTVDESQVVTRYAYVLFYRRRNSPVE--RPPRAGHSEHHP----DLGPAAEAAASQASRI 1352

  Fly   574 WLSRLATFSEP--------GPINNQEML--CPHG--------------GILHSKADVISQIAVP- 613
            | ..|....||        ||...|:.:  .|.|              |.:.:...::..:..|
Human  1353 W-QELEAEEEPVPEGSGPLGPWGPQDWVGPLPRGPTTPDEGCLRYFVLGTVAALVALVLNVFYPL 1416

  Fly   614 ISQPLW 619
            :||..|
Human  1417 VSQSRW 1422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	142/735 (19%)
		Peptidase_C19	80..>204	CDD:271592	40/133 (30%)
		Peptidase_C19R	307..538	CDD:239139	66/301 (22%)
		DUSP	560..643	CDD:197831	17/92 (18%)
		DUSP	667..755	CDD:197831
USP19	XP_005264880.1	p23_like	120..202	CDD:107220
		p23_CS_SGT1_like	391..487	CDD:107223
		USP19_linker	478..600	CDD:293210	166/851 (20%)
		Peptidase_C19	574..>707	CDD:271592	36/121 (30%)
		Peptidase_C19	603..>789	CDD:271592	47/201 (23%)
		USP7_C2	803..>862	CDD:291217	7/58 (12%)
		zf-MYND	896..938	CDD:280009	3/41 (7%)
		Peptidase_C19R	<1160..1317	CDD:239139	50/156 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900