DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp20-33 and USP16

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	NP_001027582.1	Gene:	USP16 / 10600	HGNCID:	12614	Length:	823	Species:	Homo sapiens

Alignment Length:	652	Identity:	136/652 - (20%)
Similarity:	229/652 - (35%)	Gaps:	219/652 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 GLQNIANTCYMNSALQALSNLPPM-----------THYFINCSDLVEYIAEQSARRCKPGG---L 131
            ||.|:.|||:.|:.:|.||..|.:           |...|...||.  :.|......:|.|   |
Human   197 GLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDLA--LTEPLEINLEPPGPLTL 259

  Fly   132 AKS-YRRLMQEIWQDVDDPKEF---IAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEEL 192
            |.| :...|||..:.|..|||.   :..:.:         .|:||||.|:||.||..:|.:..|.
Human   260 AMSQFLNEMQETKKGVVTPKELFSQVCKKAV---------RFKGYQQQDSQELLRYLLDGMRAEE 315

  Fly   193 TEQVS-------------MLPQTQNQPQYQSLQQQQPSETD-------------DE--------- 222
            .::||             :..:.:|:.:....::..||..|             |:
Human   316 HQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGGELTSMIMCDQCRTVSLVHE 380

  Fly   223 ---------NDDEAAPASLS--HASESEYDTCESSMSERSAEVLLKTEYFVTPCRTNGSNSGLPE 276
                     .||::...|::  :..::..|..:.|..|:..:..:|            ..|.:|.
Human   381 SFLDLSLPVLDDQSGKKSVNDKNLKKTVEDEDQDSEEEKDNDSYIK------------ERSDIPS 433

  Fly   277 GHSVQLQQAPLQHQQKNASS----------------------AEQKPIEAARSIISDV------- 312
            |.|..||:...:..:|.|.:                      .|....||..|:..:|
Human   434 GTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICTIDHPEDSEYEAEMSLQGEVNIKSNHI 498

  Fly   313 ----------------FDG--KLLSSVQCLTCDRVSTREETFQDLSL--------PIPNRDF--- 348
                            .:|  |::.||   |.::.||.|...:::::        ..|.|:.
Human   499 SQEGVMHKEYCVNQKDLNGQAKMIESV---TDNQKSTEEVDMKNINMDNDLEVLTSSPTRNLNGA 560

  Fly   349 --------------------LNVLHQTHSLSVQSLNAAETSAR-----TNEGWLSWMWNMLRSWI 388
                                ||.......::::.||.:.|...     .||...:....:....:
Human   561 YLTEGSNGEVDISNGFKNLNLNAALHPDEINIEILNDSHTPGTKVYEVVNEDPETAFCTLANREV 625

  Fly   389 YG-PSVTLYDCMASFFSADELKGDNMYSCE-----RCNKLRTGIKYSR------------VLTLP 435
            :. ...::..|:..|...::|:..|...||     :||..:..||..|            :...|
Human   626 FNTDECSIQHCLYQFTRNEKLRDANKLLCEVCTRRQCNGPKANIKGERKHVYTNAKKQMLISLAP 690

  Fly   436 EVLCIHLKRFRNDLSYSSKISSDVYFPLEGFDMRPYIHKDCKSEV-----AIYNLSSVICHHGTV 495
            .||.:|||||:.......|::..:.|| |..|:.|:....||:..     .:|:|..|:.|.||:
Human   691 PVLTLHLKRFQQAGFNLRKVNKHIKFP-EILDLAPFCTLKCKNVAEENTRVLYSLYGVVEHSGTM 754

  Fly   496 GGGHYTCFAR-NTLN---------------------GKWYEFDDQFVTEVSSELVQSCQAYVLFY 538
            ..||||.:|: .|.|                     |:|:...|..|..|.:..|.:.|||:|||
Human   755 RSGHYTAYAKARTANSHLSNLVLHGDIPQDFEMESKGQWFHISDTHVQAVPTTKVLNSQAYLLFY 819

  Fly   539 HK 540
            .:
Human   820 ER 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	134/648 (21%)
		Peptidase_C19	80..>204	CDD:271592	42/153 (27%)
		Peptidase_C19R	307..538	CDD:239139	69/336 (21%)
		DUSP	560..643	CDD:197831
		DUSP	667..755	CDD:197831
USP16	NP_001027582.1	zf-UBP	48..123	CDD:280334
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..189
		Peptidase_C19K	197..>402	CDD:239132	50/215 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..460		13/77 (17%)
		Peptidase_C19K	<623..820	CDD:239132	51/197 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900