DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp20-33 and usp15

DIOPT Version :9

Sequence 1:	NP_610943.2	Gene:	Usp20-33 / 36580	FlyBaseID:	FBgn0033916	Length:	975	Species:	Drosophila melanogaster
Sequence 2:	XP_012814096.1	Gene:	usp15 / 100158604	XenbaseID:	XB-GENE-1008519	Length:	984	Species:	Xenopus tropicalis

Alignment Length:	698	Identity:	161/698 - (23%)
Similarity:	241/698 - (34%)	Gaps:	242/698 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GLVGLQNIANTCYMNSALQALSNLPPMTHYFINCSDLVEYIAEQSARRCKPGGLAKSYRRLMQEI 142
            ||.||.|:.|||:||||:|.|||.||:|.||:|  |..:............|.:||||..|::::
Frog   286 GLCGLSNLGNTCFMNSAIQCLSNTPPLTEYFLN--DKYQDELNMDNPLGMRGEIAKSYAELIKQM 348

  Fly   143 WQDVDDPKEFIAPRGILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTEQVSMLPQTQNQPQ 207
            |   .....::.||.....:....|.|.||||.|.||.|...:|.|||:|.       :.:.:|.
Frog   349 W---SGKYSYVTPRAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLN-------RIRKKPY 403

  Fly   208 YQSLQQQQPSETDDENDDEAA-PASLSHASESE-------------------------------Y 240
            .|.      .:.|...|...| .|..:|...::                               |
Frog   404 IQL------KDADGRPDKVVAEEAWENHIKRNDSIIVDIFHGLFKSTLVCPECSKISVTFDPFCY 462

  Fly   241 DTCESSM-SERSAEV-LLKTEYFVTP----------------CRTNGSNSGL-PEG--------- 277
            .|....| .||:.|| |::.:....|                |....|.||: ||.
Frog   463 LTLPLPMKKERALEVYLVRMDPLAKPMQYKVIVPKIGNIMDLCTALSSLSGIAPEKMVVTDIYNH 527

  Fly   278 --HSV----------------------------------------QLQQAPLQHQQKNASSAEQK 300
              |.:                                        :.:.....|...:....:..
Frog   528 RFHRIFAMDENLSSIMERDDIYVFETSINRTEDTEQVIIPVYLREKFRHTSYSHHHGSTLFGQPF 592

  Fly   301 PIEAARSIISDVFDGKLLSSVQC---------------LTCDRVST------------------- 331
            .|...|:|..|.....||..: |               |.|::..|
Frog   593 LITVPRNITEDKLYNLLLLRM-CRYVKATNDTEENDGSLHCNKEHTVNGNGPNGIHEEGSPSEME 656

  Fly   332 ----REETFQDLSLPIPN------------RDFLNVLHQTHSLSVQSLNAA-------------- 366
                .:|:.||..||..|            .|..|.|....:...||:...
Frog   657 TDEPDDESSQDQELPSENENSQSEDSVGGDNDSENGLCTEDTCKGQSVTGQKKRLFTFQFSNLGS 721

  Fly   367 ----------------ETSARTNE-GWLSWMWN-MLRSWIYGPS--------------------V 393
                            |...|.:| .:|:..|: .|:...:..:                    :
Frog   722 SDITYIKDDTKYIRFDERQLRLDERSYLALDWDPKLKKKFFDENAAEDFEKHESVDFTPQKKAFM 786

  Fly   394 TLYDCMASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLPEVLCIHLKRFRNDLSYS----SK 454
            .|.||:..|.:.::|..::.:.|..|.:.:...|...:.:||.||.:|||||    |||    .|
Frog   787 KLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATKKLDLWSLPPVLVVHLKRF----SYSRYMRDK 847

  Fly   455 ISSDVYFPLEGFDMRPYIHKDCKSEVAIYNLSSVICHHGTVGGGHYTCFARNTLNGKWYEFDDQF 519
            :.:.|.||:...||..::... .:....|||.:|..|:|.:||||||.||:|..:||||.|||..
Frog   848 LDTLVDFPISDLDMSTFLINP-NAGPCCYNLIAVSNHYGGMGGGHYTAFAKNKDDGKWYYFDDSS 911

  Fly   520 VTEVSSELVQSCQAYVLFYHKHNPQMKLVRDEAMTLSTSHPLCDSDIQ 567
            |:..|.|.:.|..||||||.         |.:.:|.:...|| |.:::
Frog   912 VSTASEEQIVSKAAYVLFYQ---------RQDTITGTGFFPL-DKEVK 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp20-33	NP_610943.2	UCH	79..538	CDD:278850	153/666 (23%)
		Peptidase_C19	80..>204	CDD:271592	45/123 (37%)
		Peptidase_C19R	307..538	CDD:239139	81/336 (24%)
		DUSP	560..643	CDD:197831	3/8 (38%)
		DUSP	667..755	CDD:197831
usp15	XP_012814096.1	UBP12	27..932	CDD:227847	156/678 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910