Protein Alignment IREB2 and mAcon1

DIOPT Version :9

• Sequence 1: NP_004127.2
• Gene: IREB2 / 3658
• HGNCID: 6115
• Length: 963
• Species: Homo sapiens
• Sequence 2: NP_001097186.2
• Gene: mAcon1 / 44149
• FlyBaseID: FBgn0010100
• Length: 787
• Species: Drosophila melanogaster
• Alignment Length: 973
• Identity: 241/973 - (24%)
• Similarity: 376/973 - (38%)
• Gaps: 260/973 - (26%)

Human    22 HKKFFDVSKLG-TKYD---VLPY-SIRVLLEAAVRNCDGFLMKKEDVM-NILDWKTKQSNVEVPF 80
            |...:..||:. :|:|   .||| .:...||......:..|...|.|: :.||....|..|....
  Fly    30 HASCYTASKVALSKFDSDVYLPYEKLNKRLEVVRGRLNRPLTLSEKVLYSHLDDPANQDIVRGTS 94

Human    81 F----PARVLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQN 141
            :    |.||.:||.|...|::.|         :....:||  |.|:.:..||.::....
  Fly    95 YLRLRPDRVAMQDATAQMALLQF---------ISSGLKKV--AVPSTVHCDHLIEAQIG------ 142

Human   142 APNPGGGDLQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQ 206
                |..||.:|..|:      |::.....:||
  Fly   143 ----GPKDLARAKDLN------KEVYDFLASTC-------------------------------- 165

Human   207 PVPEPETVLKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEEKDLL 271
                         .::|     |.|:|             ||:|:.|||.||          :..
  Fly   166 -------------AKYG-----LGFWK-------------PGSGIIHQIILE----------NYA 189

Human   272 FPD-SVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDV 335
            ||. .::|||||.....|||.|..||||.:...||..:|..|..|:|:|..|||..:.:.:..||
  Fly   190 FPGLLMIGTDSHTPNGGGLGGLCIGVGGADAVDVMADIPWELKCPKVIGVNLTGKISGWTSPKDV 254

Human   336 VLGITKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGF 400
            :|.:...|...|..|..:|:.|.||..:|.....||.||..|.||..|.||.:.....:|:.||
  Fly   255 ILKVADILTVKGGTGAIIEYHGKGVDSISCTGMATICNMGAEIGATTSLFPFNQRMADYLKSTG- 318

Human   401 SKAKLESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQ-----DRVAVTDM 460
             :|.:.| |......|:...|:|.    ||.::|:|||:::.|.|:||..|.     .::.....
  Fly   319 -RAGIAS-EAQKYQAKILSADKNC----EYDELIEINLDTLEPHVNGPFTPDLGHPISKLGENSK 377

Human   461 KSDFQACLNEKVGFKGFQIAAEKQKDIVSIHYEGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAG 525
            |:.:.  ::.:||..|                                  ||||:....:...|.
  Fly   378 KNGYP--MDIRVGLIG----------------------------------SCTNSSYEDMGRCAS 406

Human   526 LLAKKAVEAGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSICVGNTAPLSD 590
             :||.|:..||:.|  |..:::|||..:...:...|:.....|.|..::...|..|:|...
  Fly   407 -IAKDAMSHGLKSK--IPFNVTPGSEQIRATIERDGISEVFDKFGGTVLANACGPCIGQWD---- 464

Human   591 AVLNAVKQGDLVTCGILSGNKNFEGR-----LCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPL 650
              ...||:||..|. :.|.|:||.||     ...|    ::.||.||.|.:|||  .:||  .||
  Fly   465 --RKDVKKGDKNTI-VTSYNRNFTGRNDANPATHC----FVTSPELVTALSIAG--RLDF--NPL 518

Human   651 GTDPTGKNIYLHDIWPSREEVHRVEEEHVILSMFKALKDKIEMGNK--------RWNSLEAP--- 704
            ..:.||.:                         .|..|.|...|::        ..::..||
  Fly   519 TDELTGAD-------------------------GKKFKLKAPFGDELPAKGFDPGQDTYTAPPPS 558

Human   705 -DSVLFPWDLKSTYIRCPSFFDKLTKEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAA 768
             ::|....|.|||.::....|||...     |.:.:..||:.:....||||||.||...:.....
  Fly   559 GENVKVAVDPKSTRLQLLEPFDKWNG-----QDLTDLTVLIKVKGKCTTDHISAAGPWLKYRGHL 618

Human   769 KYLTNR---GLTPREFNSYGARRGNDAVMTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEA 830
            ..::|.   |.|..|.|...               |||              :..:|....|.:.
  Fly   619 DNISNNMFIGATNYENNEMN---------------NIK--------------NQRNGSWGGVPDV 654

Human   831 AELYQKEGIPLIILAGKKYGSGNSRDWAAKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLP 895
            |..|:..||..:.:..:.||.|:||:.||..|..||.:|::.:|:.:||:.:|...|:.||.|..
  Fly   655 ARDYKANGIKWVAVGDENYGEGSSREHAALEPRHLGGRAIIVKSFARIHETNLKKQGLLPLTFAN 719

Human   896 GENADSLGLSGRETFSLTFPEELSPGITLNIQTSTG-KVFSVIASFE-DDVEITLYKHGGLLN 956
            ..:.|.:..:.:  .||...:.|:||..::.:...| ||..:..:.. :|::|..:|.|..||
  Fly   720 PADYDKIQPTSK--ISLLNLKSLAPGKPVDAEIKNGDKVERIKLNHTLNDLQIGWFKAGSALN 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IREB2	NP_004127.2	AcnA	10..961	CDD:333196	241/973 (25%)
mAcon1	NP_001097186.2	aconitase_mito	52..782	CDD:273561	234/951 (25%)
		AcnA_Mitochondrial	102..513	CDD:153134	144/569 (25%)
		AcnA_Mitochon_Swivel	595..743	CDD:238810	45/178 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820