Protein Alignment IREB2 and Irp-1B

DIOPT Version :9

• Sequence 1: NP_004127.2
• Gene: IREB2 / 3658
• HGNCID: 6115
• Length: 963
• Species: Homo sapiens
• Sequence 2: NP_524303.2
• Gene: Irp-1B / 41269
• FlyBaseID: FBgn0024957
• Length: 899
• Species: Drosophila melanogaster
• Alignment Length: 949
• Identity: 511/949 - (53%)
• Similarity: 681/949 - (71%)
• Gaps: 85/949 - (8%)

Human    24 KFFDVSKLGTKYDVLPYSIRVLLEAAVRNCDGFLMKKEDVMNILDW----KTKQSNVEVPFFPAR 84
            |:||::.:.:|||.||||||||||:||||||.|.:.::||.:||.|    |...::|||.|.|||
  Fly    22 KYFDLASIDSKYDQLPYSIRVLLESAVRNCDNFHILEKDVQSILGWSPALKQGSNDVEVSFKPAR 86

Human    85 VLLQDFTGIPAMVDFAAMREAVKTLGGDPEKVHPACPTDLTVDHSLQIDFSKCAIQNAPNPGGGD 149
            |:||||||:||:|||||||:||..|||||||::|.||.||.:|||:|:||::.
  Fly    87 VILQDFTGVPAVVDFAAMRDAVLDLGGDPEKINPICPADLVIDHSVQVDFARA------------ 139

Human   150 LQKAGKLSPLKVQPKKLPCRGQTTCRGSCDSGELGRNSGTFSSQIENTPILCPFHLQPVPEPETV 214
                                                                         |:.:
  Fly   140 -------------------------------------------------------------PDAL 143

Human   215 LKNQEVEFGRNRERLQFFKWSSRVFKNVAVIPPGTGMAHQINLEYLSRVVFEE-----KDLLFPD 274
            .|||.:||.||:||..|.||.::.|.|:.::|||:|:.||:|||||:|||||.     ..:|:||
  Fly   144 AKNQSLEFERNKERFTFLKWGAKAFNNMLIVPPGSGIVHQVNLEYLARVVFENDATDGSKILYPD 208

Human   275 SVVGTDSHITMVNGLGILGWGVGGIETEAVMLGLPVSLTLPEVVGCELTGSSNPFVTSIDVVLGI 339
            ||||||||.||:||||:|||||||||.||||||..:|:.||||:|.:|.|..:|.|||.|:||.|
  Fly   209 SVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYKLEGKLSPLVTSTDLVLTI 273

Human   340 TKHLRQVGVAGKFVEFFGSGVSQLSIVDRTTIANMCPEYGAILSFFPVDNVTLKHLEHTGFSKAK 404
            ||||||:||.||||||:|.||::|||.||.||:||||||||.:.:||:|..||.:::.|..|:.|
  Fly   274 TKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLGYMKQTNRSEKK 338

Human   405 LESMETYLKAVKLFRNDQNSSGEPEYSQVIQINLNSIVPSVSGPKRPQDRVAVTDMKSDFQACLN 469
            ::.:..||||.:..||..:::.:|:::|.|.::|:::|.||||||||.|||:|:||..||::||:
  Fly   339 IDIIRQYLKATQQLRNYADAAQDPKFTQSITLDLSTVVTSVSGPKRPHDRVSVSDMPEDFKSCLS 403

Human   470 EKVGFKGFQIAAEKQKDIVSIHY-EGSEYKLSHGSVVIAAVISCTNNCNPSVMLAAGLLAKKAVE 533
            ..||||||.||.|.|.......: :|..|||.||||||||:.||||..||||||.||||||||||
  Fly   404 SPVGFKGFAIAPEAQSAFGEFQWDDGKTYKLHHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVE 468

Human   534 AGLRVKPYIRTSLSPGSGMVTHYLSSSGVLPYLSKLGFEIVGYGCSICVGNTAPLSDAVLNAVKQ 598
            .||.:.|||:||||||||:||:||..|||:|||.||||:||||||..|:||:.||.:.|:|.:::
  Fly   469 KGLSILPYIKTSLSPGSGVVTYYLKESGVIPYLEKLGFDIVGYGCMTCIGNSGPLEENVVNTIEK 533

Human   599 GDLVTCGILSGNKNFEGRLCDCVRANYLASPPLVVAYAIAGTVNIDFQTEPLGTDPTGKNIYLHD 663
            ..||..|:||||:|||||:....||||||||.||:||||||.|:|||:.||||.|..|||::|.|
  Fly   534 NGLVCAGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEKEPLGVDANGKNVFLQD 598

Human   664 IWPSREEVHRVEEEHVILSMFKALKDKIEMGNKRWNSLEAPDSVLFPWDLKSTYIRCPSFFDKLT 728
            |||:|.|:..||.:|||.:||:.:..|||:|::.|.:|:..:..||.|...||||:.|.||:.:|
  Fly   599 IWPTRSEIQEVENKHVIPAMFQEVYSKIELGSQDWQTLQVSEGKLFSWSADSTYIKRPPFFEGMT 663

Human   729 KEPIALQAIENAHVLLYLGDSVTTDHISPAGSIARNSAAAKYLTNRGLTPREFNSYGARRGNDAV 793
            ::...||:|:.|..||:||||||||||||||||||.|.||::|:.|.:|||:|||||:||||||:
  Fly   664 RDLPKLQSIQKARCLLFLGDSVTTDHISPAGSIARTSPAARFLSERNITPRDFNSYGSRRGNDAI 728

Human   794 MTRGTFANIKLFNKFIGKPAPKTIHFPSGQTLDVFEAAELYQKEGIPLIILAGKKYGSGNSRDWA 858
            |:|||||||:|.||.:.|..|:|:|.||.:.||:|:|||.|::||.||:::.||.||||:|||||
  Fly   729 MSRGTFANIRLVNKLVEKTGPRTVHIPSQEELDIFDAAERYREEGTPLVLVVGKDYGSGSSRDWA 793

Human   859 AKGPYLLGVKAVLAESYEKIHKDHLIGIGIAPLQFLPGENADSLGLSGRETFSLTFPEE-LSPGI 922
            ||||:|||||||:|||||:||:.:|:|:||.|||||||::|::|.|:|||.:::..||. |.||.
  Fly   794 AKGPFLLGVKAVIAESYERIHRSNLVGMGIIPLQFLPGQSAETLNLTGREVYNIALPESGLKPGQ 858

Human   923 TLNIQTSTGKVFSVIASFEDDVEITLYKHGGLLNFVARK 961
            .:.:: :.|.||..|..|:.:|:||.||:||:||::.||
  Fly   859 KIQVE-ADGTVFETILRFDTEVDITYYKNGGILNYMIRK 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IREB2	NP_004127.2	AcnA	10..961	CDD:333196	509/947 (54%)
Irp-1B	NP_524303.2	PTZ00092	1..899	CDD:240263	511/949 (54%)
		AcnA_IRP	86..576	CDD:153136	295/562 (52%)
		AcnA_IRP_Swivel	680..849	CDD:238812	111/168 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10470
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101028
Panther	1	1.100	-	-	O	PTHR11670
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X803
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.790