Protein Alignment Snrk and HRK1

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_014910.1
• Gene: HRK1 / 854441
• SGDID: S000005793
• Length: 759
• Species: Saccharomyces cerevisiae
• Alignment Length: 669
• Identity: 140/669 - (20%)
• Similarity: 216/669 - (32%)
• Gaps: 214/669 - (31%)

  Fly    14 GKIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCM------K 72
            ||:..|      ||||....||:......||..|||.....|.::..|.:   ..:|.      .
Yeast   215 GKLGKL------LGSGAGGSVKVLVRPTDGATFAVKEFRPRKPNESVKEY---AKKCTAEFCIGS 270

  Fly    73 LVQHPNVVRLYEVI--DTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCH 135
            .:.||||:...:|.  ..|.|.|.|:|... .|.:..:|  ...:|........:|:...:.|.|
Yeast   271 TLHHPNVIETVDVFSDSKQNKYYEVMEYCP-IDFFAVVM--TGKMSRGEINCCLKQLTEGVKYLH 332

  Fly   136 QLHVVHRDLKPENVVFFEKLGLVKLTDFG----FSNKFLPGQKL-ETFCGSLAYSAPEILLG-DS 194
            .:.:.|||||.:|.|...: |::||.|||    |...|..|..: ....||..|.|||::.. .|
Yeast   333 SMGLAHRDLKLDNCVMTSQ-GILKLIDFGSAVVFRYPFEDGVTMAHGIVGSDPYLAPEVITSTKS 396

  Fly   195 YDAPAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPK 259
            ||...|||||:|:|...:|..:.|::...||:....:    |.:|..:
Yeast   397 YDPQCVDIWSIGIIYCCMVLKRFPWKAPRDSDDNFRL----YCMPDDI----------------- 440

  Fly   260 KRATVEEIASSAWLKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQA 324
                              |.|...|...|                              ||:
Yeast   441 ------------------EHDYVESARHH------------------------------EEL--- 454

  Fly   325 LDKNKYNHITATYFLLAELRLRRRREELAQKQRLLNDASMKVGDASRKLVPEKPSPTEAQKGGVP 389
                                |:.|:|   ::||.||.:..   .|..:..|...|..:..:..||
Yeast   455 --------------------LKERKE---KRQRFLNHSDC---SAINQQQPAHESNLKTVQNQVP 493

  Fly   390 ISINVTPAAQFANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTSSSRREAFSDSPFSR 454
                .|||:.......|||       ||.||.||....:.   .|:.:.|..:.:|:..|...|:
Yeast   494 ----NTPASIQGKSDNKPD-------IVEEETEENKEDDS---NNDKESTPDNDKESTIDIKISK 544

  Fly   455 SIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQMEKSAKIDEDTLSGLKELE 519
                       |:.|      |.|.|.:..|:....||         :..|..|.:
Yeast   545 -----------NENK------STVVSANPKKVDADADA---------DCDANGDSN--------- 574

  Fly   520 IGKLKPLPSSSKNPVLTHRRTKLNKIRTPSCSSSEASDDDTKTRNKKKINKFVGDTPVRFRMHRR 584
             |::....:|..|.     :|..|  ....||    ::.|...:....:|......|.....:..
Yeast   575 -GRVDCKANSDCND-----KTDCN--ANNDCS----NESDCNAKVDTNVNTAANANPDMVPQNNP 627

  Fly   585 DSHDDSSDSQDQLYPPPGSASNAGNFISKSGSVSGKKEGQSQYKEPNNKSDENRKSHS----QKN 645
            .........|.|                        ::.|.|.:..:::.....|:||    .|:
Yeast   628 QQQQQQQQQQQQ------------------------QQQQQQQQHHHHQHQNQDKAHSIASDNKS 668

  Fly   646 RKQHNKDHVDKHSHAERQL 664
            .:||...|..|..|...:|
Yeast   669 SQQHRGPHHKKIIHGPYRL 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	69/270 (26%)
		UBA_SNRK	296..338	CDD:270524	2/41 (5%)
HRK1	NP_014910.1	Protein Kinases, catalytic domain	221..435	CDD:473864	66/224 (29%)
		MSCRAMM_ClfA	<469..620	CDD:468110	41/214 (19%)
		Protein Kinases, catalytic domain	<677..721	CDD:473864	3/11 (27%)