Protein Alignment Snrk and GIN4

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_010795.3
• Gene: GIN4 / 852119
• SGDID: S000002915
• Length: 1142
• Species: Saccharomyces cerevisiae
• Alignment Length: 1017
• Identity: 246/1017 - (24%)
• Similarity: 405/1017 - (39%)
• Gaps: 244/1017 - (23%)

  Fly     1 MTLETQPVGGVSDGKIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLD-------- 57
            |.:....:..:.|..| |.:.|.||||.|....|:|||:..||.:.||||:.|...:
Yeast     1 MAINGNSIPAIKDNTI-GPWKLGETLGLGSTGKVQLARNGSTGQEAAVKVISKAVFNTGNVSGTS 64

  Fly    58 -------DVSKAHLFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGL 115
                   |.....:.:|:..|||:.||||:|||:|.:|.|.||||||..:.|:|::.:::. ..|
Yeast    65 IVGSTTPDALPYGIEREIIIMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVER-GPL 128

  Fly   116 SEELARKYFRQILRAITYCHQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCG 180
            .|..|.::||||:..::|||.|.:|||||||||::...|.. :|:.|||.:.....|:.|||.||
Yeast   129 PEHEAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYN-IKIADFGMAALETEGKLLETSCG 192

  Fly   181 SLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPF--EKANDSETLTMIMDCKYTVPS--H 241
            |..|:||||:.|..|...|.|:||.||||:.|:.|:.||  |..|....|..:...::.:||  .
Yeast   193 SPHYAAPEIVSGIPYQGFASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEFEMPSDDE 257

  Fly   242 VSTDCRDLIASMLVRDPKKRATVEEIASSAWLKPIDEPDSTTSTSEHFLP-----LVSREQLGEE 301
            :|.:.:|||..:|..||::|....:|.....|:..  |....|.|...||     |....:....
Yeast   258 ISREAQDLIRKILTVDPERRIKTRDILKHPLLQKY--PSIRDSKSIRGLPREDTYLTPLSESNSS 320

  Fly   302 DHAFIIQKMI---NGNIASKEEILQALDKNKYNHITATYFLLAELRLRRRREELAQKQRLLNDAS 363
            ..|.|:|.::   :|.  ..|.|.:.|.:...|.....|.||...:...::|.:.|:|.....:.
Yeast   321 IDATILQNLVILWHGR--DPEGIKEKLREPGANAEKTLYALLYRFKCDTQKELIKQQQVKKRQSI 383

  Fly   364 MKVGDASRKLVPEKP----------SPTEAQKGGVPISIN------------VTPAA------QF 400
            ..|..:..|.|...|          |.|.::|  .|||.|            .||.:      .|
Yeast   384 SSVSVSPSKKVSTTPQRRRNRESLISVTSSRK--KPISFNKFTASSASSSNLTTPGSSKRLSKNF 446

  Fly   401 AN----------DGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTSSSRREAFSDSPFSRS 455
            ::          ....|..|:::.|::..|..::.|:          :.|::::...|    |||
Yeast   447 SSKKKLSTIVNQSSPTPASRNKRASVINVEKNQKRAS----------IFSTTKKNKRS----SRS 497

  Fly   456 IHERSSSEPGNQTKGEQIANSGVPSHSR-------------TKIVVSVDATLAHKLKQMEKSAKI 507
            | :|.|..|  ..|.|.:....:.::::             ||...|..|||..::.:.||..:|
Yeast   498 I-KRMSLIP--SMKRESVTTKLMSTYAKLAEDDDWEYIEKETKRTSSNFATLIDEIFEYEKYEQI 559

  Fly   508 DEDTLSGLKELEIGKLKPLPSSSKNPVLTHRRTKLNKIRTPSCSSSEASDDDTKTRN---KKKIN 569
            .::.    :|||   .|...:.::..:...||.:..|.|.......|    |.|.:.   ||:|.
Yeast   560 RKEK----EELE---RKVREAKAREELERRRRKQEEKERARKLLEKE----DLKRKQEELKKQIE 613

  Fly   570 KFVGDTPVRFRMHRRDSHDDS-------------------------------------------- 590
            ..:.|.......|:.:..|.:
Yeast   614 IDISDLEQELSKHKEEKLDGNIRSISAPMENEEKNINHLEVDIDNILRRRNFSLQTRPVSRLDPG 678

  Fly   591 ---SDSQDQLYP-PPGSASN--------------AGNFISKSGSVSGK-KEGQSQYKE---PNNK 633
               |...:::.| .|....|              ...|:..|.::..: |..:.:|..   |...
Yeast   679 IMFSSPTEEVSPVEPKRTENERLTTEKKILETIRRSKFLGSSFNIDKELKLSKMEYPSIIAPQRL 743

  Fly   634 SDENRKSHSQKNRKQHNKDHVDKHSHAERQLADSSTATTGNSTNRRRRIRESQSLDRITEAQEYE 698
            |:|...|.|...   :....:.|..:...||.||:..|...|..|.|:|.|       ....::.
Yeast   744 SEERVVSDSNDG---YESLILPKDGNGVSQLKDSTATTAPVSDGRLRKISE-------IRVPQFT 798

  Fly   699 MRHRCYAESEAASSSSSSTQHIDQRYSLLSLNTSTFSVAETKEEY--------DEEADATNATDQ 755
            .:.|.::||             ::|.|:||:.:       |||.:        :...|..|...|
Yeast   799 RKSRHFSES-------------NKRLSVLSMYS-------TKESFTNLVDILKNGNLDVNNQQSQ 843

  Fly   756 IMNTLNAAK------ATLQQE-QYFNNNTNLSRNFNHN----HNQSIIHIS-SQKANGKKSNETP 808
            .:.|..:|.      .|:.:| :|..|::|..|.::..    .::|.:.:: :.:.||  |||.
Yeast   844 RIPTPRSADDSEFLFETVNEEAEYTGNSSNDERLYDVGDSTIKDKSALKLNFADRFNG--SNEA- 905

  Fly   809 KDIYNLNSIEHIDLILE---DKSLTKAIHVTGSKCFVTMKKI 847
            |...||    |:.::..   |..|.|.....|.:....:|.:
Yeast   906 KQTDNL----HLPILPPLNGDNELRKQNSQEGDQAHPKIKSM 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	107/275 (39%)
		UBA_SNRK	296..338	CDD:270524	8/44 (18%)
GIN4	NP_010795.3	Protein Kinases, catalytic domain	17..289	CDD:473864	106/273 (39%)
		Kcc4p_like_C	1026..1139	CDD:213379