Protein Alignment Snrk and SNF1

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_010765.3
• Gene: SNF1 / 852088
• SGDID: S000002885
• Length: 633
• Species: Saccharomyces cerevisiae
• Alignment Length: 620
• Identity: 180/620 - (29%)
• Similarity: 290/620 - (46%)
• Gaps: 122/620 - (19%)

  Fly     7 PVGGVSDGKIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKL--DDVSKAHLFQEVR 69
            |...::||...|.|.:.:|||.|.|..||||.|..||.|||:|:::|..|  .|: :..:.:|:.
Yeast    42 PKSSLADGAHIGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDM-QGRIEREIS 105

  Fly    70 CMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYC 134
            .::|::||::::||:||.::.::.:|:|.. |.:|:|||::.|. :||:.||::|:||:.|:.||
Yeast   106 YLRLLRHPHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRDK-MSEQEARRFFQQIISAVEYC 168

  Fly   135 HQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPA 199
            |:..:|||||||||::..|.|. ||:.|||.||....|..|:|.|||..|:|||::.|..|..|.
Yeast   169 HRHKIVHRDLKPENLLLDEHLN-VKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPE 232

  Fly   200 VDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATV 264
            ||:||.|||||:::|.:.||:..:.......|.:..||:|..:|.....||..||:.:|..|.::
Yeast   233 VDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISI 297

  Fly   265 EEIASSAWLKPIDEPDSTTSTSEHFLPLVSREQLGEE-------------DHAFIIQKMINGNIA 316
            .||....|.| :|.|       |:.||...:....||             |:..|...::  ||.
Yeast   298 HEIMQDDWFK-VDLP-------EYLLPPDLKPHPEEENENNDSKKDGSSPDNDEIDDNLV--NIL 352

  Fly   317 S------KEEILQALDKNK----YNHITATYFLLAELRLRRRREELAQKQRLLND--ASMKVGDA 369
            |      |:||.::|:.::    :|.|...|.|:.|            .:.|:.|  |:..|.|.
Yeast   353 SSTMGYEKDEIYESLESSEDTPAFNEIRDAYMLIKE------------NKSLIKDMKANKSVSDE 405

  Fly   370 SRKLVPEKPSPTEAQKGGVPISINVTPAAQFANDGGKPDKRSRKCSIVREEDEEESATECTAVGN 434
            ....:.:.| ||..|:                      .|..:|..:..|..::.:....:|:
Yeast   406 LDTFLSQSP-PTFQQQ----------------------SKSHQKSQVDHETAKQHARRMASAI-- 445

  Fly   435 ELKVTSSSRREAFSDSPFSRSIHERSSSEPGNQTKGEQI--AN---SGVPSHSR-TKIVVSVDAT 493
                   :::..:..|||.....|..|:.....|...||  ||   .|.|:.|: :.:|.....|
Yeast   446 -------TQQRTYHQSPFMDQYKEEDSTVSILPTSLPQIHRANMLAQGSPAASKISPLVTKKSKT 503

  Fly   494 LAH------------------KLKQM-EKSAKIDEDTLSGLK---ELEIGKLKPLPSSSKNPVLT 536
            ..|                  .||.: .:.||..|:.|..:|   :.:||  ....::.|.|.|.
Yeast   504 RWHFGIRSRSYPLDVMGEIYIALKNLGAEWAKPSEEDLWTIKLRWKYDIG--NKTNTNEKIPDLM 566

  Fly   537 HRRTKLNKIRTPS------CSSSEAS-DDDTKTRN 564
            ....:|.:|.|.:      ....|:| .|||...|
Yeast   567 KMVIQLFQIETNNYLVDFKFDGWESSYGDDTTVSN 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	104/258 (40%)
		UBA_SNRK	296..338	CDD:270524	13/64 (20%)
SNF1	NP_010765.3	STKc_AMPK_alpha	52..306	CDD:270981	104/257 (40%)
		UBA_2	344..389	CDD:430091	13/58 (22%)
		AdenylateSensor	504..626	CDD:406881	22/100 (22%)