Protein Alignment Snrk and KCC4

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_009907.2
• Gene: KCC4 / 850334
• SGDID: S000000529
• Length: 1037
• Species: Saccharomyces cerevisiae
• Alignment Length: 974
• Identity: 231/974 - (23%)
• Similarity: 391/974 - (40%)
• Gaps: 232/974 - (23%)

  Fly     1 MTL-ETQPVGGVSDGKIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKL-------- 56
            ||: .|:...........|.:.|.||||.|....|:||:|..||.:.||||:.|:..
Yeast     1 MTVANTETHSAAKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSN 65

  Fly    57 -DDVSKAHLFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELA 120
             |.|...::.:|:..|||:.||||:.||:|.:|...|||:||..:.|:|::.::.| ..|.|..|
Yeast    66 DDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDH-GPLPEREA 129

  Fly   121 RKYFRQILRAITYCHQLHVVHRDLKPENVV---FFEKLGLVKLTDFGFSNKFLPGQKLETFCGSL 182
            ...||||:..|:|||.|.:|||||||||::   |:.    :|:.|||.:........|||.|||.
Yeast   130 INCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYN----IKIADFGMAALQTDADLLETSCGSP 190

  Fly   183 AYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFEKANDS--ETLTMIMDCKYTVP--SHVS 243
            .|:||||:.|..|:..|.|:||.||||:.|:.|:.||::.|.:  :.|..:...::.:|  :.:|
Yeast   191 HYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEIS 255

  Fly   244 TDCRDLIASMLVRDPKKRATVEEIAS----------------------SAWLKPIDEPDSTTSTS 286
            .|.:|||..:||.||::|..:.:|.|                      :.:|.|:.:.::.||.|
Yeast   256 RDAQDLIGKILVVDPRQRIKIRDILSHPLLKKYQTIKDSKSIKDLPRENTYLYPLADSNNHTSAS 320

  Fly   287 EHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQAL--------------------DKNKYN 331
            .....|.:...|....||..|...:..|..:||:||.||                    .|.|.|
Yeast   321 IDDSILQNLVVLWHGRHADDIVSKLKENGTNKEKILYALLYRFKLDSVRGSNKKNRNKIKKTKKN 385

  Fly   332 HITATYFLLAELRLRRRREELAQKQRLLNDASMKVGDASRK----LVPEKP---SPTEAQKGGVP 389
            ..::|....:.|.|..|..:...::|.....|.:. .:|||    |:...|   ||...:.....
Yeast   386 KRSSTLSSSSSLLLNNRSIQSTPRRRTSKRHSREF-SSSRKRSSFLLSSNPTDSSPIPLRSSKRI 449

  Fly   390 ISINVTPAAQFANDGGKPD-------KRSRK---------------------CSIVREEDEEESA 426
            ..|||..|...|...|.|:       |||.|                     .:::.::|.|
Yeast   450 THINVASANTQATPSGVPNPHKRNSKKRSSKRLSYMPNTKRSSLTSKSLSNFTNLIDDDDWE--- 511

  Fly   427 TECTAVGNELKVTSSSRREAFSDSPFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVD 491
                .:..:.|.|||:         |:..|.|....|.....|.|:
Yeast   512 ----YIEKDAKRTSSN---------FATLIDEIFEPEKFELAKREK------------------- 544

  Fly   492 ATLAHKLKQMEKSA----KIDEDTL-----SGLKELEIGKLKPLPSSSKNPVLTHRRTKLNKIRT 547
            |.|..|:::.::.:    ||:||..     .|:||     ||.:.....:|::.:..::...::
Yeast   545 AELQRKVQEAKRQSVNAQKINEDEFGSEVSDGMKE-----LKKINDKVSSPLINYEFSQQELLQ- 603

  Fly   548 PSCSSSEASDDDTKTRNKKKINKFV--------GDTPVRFRM--HRRDSHDDSSDSQDQLYPPPG 602
                     |.||...|:.:::.:.        |.|||...:  :.::......|::.::.....
Yeast   604 ---------DIDTLLTNRYQLSSYTRPISRLDPGLTPVTETLPNNLKEKTALLQDTEKKIIETIR 659

  Fly   603 SASNAGNFISKSGSVS-GKKE---------------GQSQYKEPNNKSDE-----NRKSH---SQ 643
            .:...|:.::..|.:| ||.|               ..:...||...||.     .|||.   :.
Yeast   660 RSKFLGSLLNVRGGLSPGKSELAPIEESPIVSTTPLIYNDRMEPRRISDVEVPHFTRKSKHFTTA 724

  Fly   644 KNRKQ----HNKDHVDKHSHAERQLADSSTATTGNSTNRRRRIRESQSLDRITEAQEYEMRHRCY 704
            .||:.    :.||.:...:  |..:.:........||:...|..:.:..:.||:::..:     |
Yeast   725 NNRRSVLSLYAKDSIKDLN--EFLIKEDPDLPPQGSTDNESRSEDPEIAESITDSRNIQ-----Y 782

  Fly   705 AESEAASSSSSSTQH----------IDQRYSLLSLNTSTFSVAETKE-------EYDEEADATNA 752
            .|.::....:.:..:          |.|.|.:...|.:...::::.|       .........||
Yeast   783 DEDDSKDGDNVNNDNILSDFPQGVGISQEYDMKDKNPNQSPISKSAEPTLVVKLPSLSSFQGKNA 847

  Fly   753 TDQIMNTLNAAKATLQQEQYFNNNTNLSRNFNHNHNQ---------SIIHISSQKANGKKSNET 807
            :...:.....:|.||  ....:||:::..|......:         |:.....::.|.||.|:|
Yeast   848 SGLGLYQREPSKVTL--PSLTSNNSSVGENIEDGAEKGTESEKIAASLSDDDLKEDNDKKDNDT 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	106/294 (36%)
		UBA_SNRK	296..338	CDD:270524	15/61 (25%)
KCC4	NP_009907.2	Protein Kinases, catalytic domain	19..285	CDD:473864	106/270 (39%)
		Kcc4p_like_C	920..1034	CDD:213379