Protein Alignment Snrk and Prkaa2

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_076481.2
• Gene: Prkaa2 / 78975
• RGDID: 620893
• Length: 552
• Species: Rattus norvegicus
• Alignment Length: 646
• Identity: 183/646 - (28%)
• Similarity: 274/646 - (42%)
• Gaps: 162/646 - (25%)

  Fly    13 DGKI-AGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTK---LDDVSKAHLFQEVRCMKL 73
            ||:: .|.|.|.:|||.|.|..||:..|..||.|||||::::.|   ||.|.|  :.:|::.:||
  Rat     8 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK--IKREIQNLKL 70

  Fly    74 VQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEEL-ARKYFRQILRAITYCHQL 137
            .:||::::||:||.|.|..::|:|...||:|:|||.||  |..||: ||:.|:|||.|:.|||:.
  Rat    71 FRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKH--GRVEEVEARRLFQQILSAVDYCHRH 133

  Fly   138 HVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDI 202
            .|||||||||||:...::. .|:.|||.||....|:.|.|.|||..|:|||::.|..|..|.|||
  Rat   134 MVVHRDLKPENVLLDAQMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDI 197

  Fly   203 WSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEI 267
            ||.|||||.|:||..||:..:.......|....:.:|.:::.....|:..||..||.||||:::|
  Rat   198 WSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSIATLLMHMLQVDPLKRATIKDI 262

  Fly   268 ASSAWLKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQALDKNKYNH 332
            ....|.|. |.|       .:..|         ||.::      :.|:...|.:.:..:|
  Rat   263 REHEWFKQ-DLP-------SYLFP---------EDPSY------DANVIDDEAVKEVCEK----- 299

  Fly   333 ITATYFLLAELRLRRR------REELAQKQRLLNDASMKVGDASRKLVPEKPSPTEAQKGGVPIS 391
                 |...|..:...      :::||....|:.|....:..||...:...|
  Rat   300 -----FECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSP------------- 346

  Fly   392 INVTPAAQFANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTSSSRREAFSDSPFSRSI 456
                |...|.:|                     ||..   :...||..........:|||
  Rat   347 ----PTGSFMDD---------------------SAMH---IPPGLKPHPERMPPLIADSP----- 378

  Fly   457 HERSSSEPGNQTKGEQIA------NSGVPSHSRTKIVVSVDATLAHKLKQMEKSAKIDEDTLSGL 515
            ..|...:..|.||.:.:|      :.|:.|.|:.   ..:.|.:...:||::...|:     ...
  Rat   379 KARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKP---YDIMAEVYRAMKQLDFEWKV-----VNA 435

  Fly   516 KELEIGKLKPLPSSSKNPV------------LTHRRTKLNKIRTPSCSSSEASDDDTKTRNKKKI 568
            ..|.:.:        ||||            |...|:.|...:         |.||.....:..
  Rat   436 YHLRVRR--------KNPVTGNYVKMSLQLYLVDNRSYLLDFK---------SIDDEVVEQRSG- 482

  Fly   569 NKFVGDTPVR----FRMHRRDSHDDSSDSQDQLYPPPGSASNAGNFISKSGSVSGKKEGQS 625
                ..||.|    ..:||..|..|||.:::.               |.|||::|...|.:
  Rat   483 ----SSTPQRSCSAAGLHRPRSSVDSSTAENH---------------SLSGSLTGSLTGST 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	114/261 (44%)
		UBA_SNRK	296..338	CDD:270524	5/41 (12%)
Prkaa2	NP_076481.2	STKc_AMPK_alpha	13..268	CDD:270981	114/259 (44%)
		UBA_AID_AAPK2	285..349	CDD:270587	13/90 (14%)
		AIS. /evidence=ECO:0000250|UniProtKB:Q13131	291..376		18/135 (13%)
		AMPKA2_C	395..550	CDD:213385	34/175 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..520		14/61 (23%)