Protein Alignment Snrk and Sik3

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_001258145.2
• Gene: Sik3 / 684112
• RGDID: 1593938
• Length: 1369
• Species: Rattus norvegicus
• Alignment Length: 761
• Identity: 210/761 - (27%)
• Similarity: 361/761 - (47%)
• Gaps: 134/761 - (17%)

  Fly     6 QPVGGVSDGKIA---GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQE 67
            :|....|.|.:|   |.|:::.|:|.|:|||||.|.|:.|.||||:|::|||:||:.:...:|:|
  Rat    49 RPTAPASRGSMAARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFRE 113

  Fly    68 VRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAIT 132
            |:.||::.||:::|||:|::|:..:|||.|...||:::|:::.| ..::|:.||:.|:||:.|:.
  Rat   114 VQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH-GRMAEKEARRKFKQIVTAVY 177

  Fly   133 YCHQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDA 197
            :||..::||||||.||::....|. :|:.||||||.|.|||.|:|:|||..|:|||:..|..||.
  Rat   178 FCHCRNIVHRDLKAENLLLDANLN-IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEYDG 241

  Fly   198 PAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRA 262
            |.||||||||:||:||||..||:.:........::..|:.:|..:||:|..||..|||.||.||.
  Rat   242 PKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNKRL 306

  Fly   263 TVEEIASSAWLKPIDEPDSTTSTSEHFLPLVSR-EQLGEEDHAFIIQKMINGNI--------ASK 318
            ::|:|....|:|..|       ...:|..|::. :||.||..|    :.:|..:        ..|
  Rat   307 SMEQICRHRWMKLGD-------ADPNFERLIAECQQLKEERQA----EPLNDEVLLAMEDMGLDK 360

  Fly   319 EEILQALDKNKYNHITATYFLLAELRLRRRREELAQKQRLLNDASMKVGDASRKLVPEKPSPTEA 383
            |..||:|..:.|:|.:|.|.||.:..         :|.:.|...::.  ...:.:..:.|...:|
  Rat   361 ERTLQSLRSDAYDHYSAIYSLLCDRH---------KKNKTLRPGALP--STPQAMTFQAPVNIQA 414

  Fly   384 QKGGVPISINVTPAAQFANDGG---KPDKRSRKCSIVREEDE-EESATECTAVGNELKVTSSSRR 444
            ::.|..::|:| |..|..|...   :||.     ::..:.|| ||.:.|..     ::..|..|.
  Rat   415 EQTGTAMNISV-PQVQLINPENQIIEPDG-----AVNLDSDEGEEPSPEAL-----VRYLSMRRH 468

  Fly   445 EAFSDSPFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQME------- 502
            ......|.:..:.|.....||...     ||...|.     :.|:.:....|.|..|:
  Rat   469 TVGVADPRTEVMDEMQKLLPGFPG-----ANPQTPF-----LQVAPNMNFMHNLLPMQSLQPTGQ 523

  Fly   503 ----KSAKIDEDTLSGLKELEIGKLKPLPSSSKNPVLTHRRTKLNKIRTPS-------------C 550
                :.:.:...||..|..:  |.|....|.....:..|.:..|.:.|.||             .
  Rat   524 LEYKEQSLLQPPTLQLLNGM--GPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTP 586

  Fly   551 SSSEASDDDTKTRNKKKINKFVGDTPVRFRMHRRD-SHDDSSDSQDQLYPPPGSASNAGNFISKS 614
            ...|:||.:.   :::.:.:::.:...|..:.... :.:...|.|.||
  Rat   587 VDEESSDGEP---DQEAVQRYLANRSKRHTLAMTSPTAEIPPDLQRQL----------------- 631

  Fly   615 GSVSGKKEGQSQYKEPNNKSDENRKSHSQKNRKQHNKDHVDKHSHAE-RQLADSSTA-------- 670
                |::..:|:...|:...|::|.::     |..|..|:.....:. |:.:|.:.:
  Rat   632 ----GQQSFRSRVWPPHLVPDQHRSTY-----KDSNTLHLPTERFSPVRRFSDGAASIQAFKAHL 687

  Fly   671 -TTGNSTNRRRRIRESQSLDRITEAQ-------EYEMRHRCYAESE 708
             ..|||::.::..:|.:.|.::...|       :.:.:|..|.:.:
  Rat   688 ERMGNSSSIKQLQQECEQLQKMYGGQVDERTLEKTQQQHMLYQQEQ 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	118/259 (46%)
		UBA_SNRK	296..338	CDD:270524	14/49 (29%)
Sik3	NP_001258145.2	STKc_SIK	65..317	CDD:270973	116/253 (46%)
		UBA_like_SF	346..390	CDD:473871	13/52 (25%)