Protein Alignment Snrk and mark2

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: XP_012808991.1
• Gene: mark2 / 594939
• XenbaseID: XB-GENE-876451
• Length: 792
• Species: Xenopus tropicalis
• Alignment Length: 760
• Identity: 234/760 - (30%)
• Similarity: 348/760 - (45%)
• Gaps: 127/760 - (16%)

  Fly    18 GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHPNVVRL 82
            |.|.|.:|:|.|:||.|||||||.||.:||||::|||:|:..|...||:|||.||::.|||:|:|
 Frog    62 GNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 126

  Fly    83 YEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPE 147
            :|||:|:..||||:|...||:::||::.| ..:.|:.||..||||:.|:.||||..:||||||.|
 Frog   127 FEVIETEKTLYLVMEYASGGEVFDYLVAH-GRMKEKEARAKFRQIVSAVQYCHQKLIVHRDLKAE 190

  Fly   148 NVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYML 212
            |::....:. :|:.||||||:|..|.||:|||||..|:|||:..|..||.|.||:||||||||.|
 Frog   191 NLLLDSDMN-IKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 254

  Fly   213 VCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAW----- 272
            |.|..||:..|..|....::..||.:|.::||||.:|:...|:.:|.||.|:|:|....|
 Frog   255 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPAKRGTLEQIMRDRWMNVGH 319

  Fly   273 ----LKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQALDKNKYNHI 333
                |||..||     ..::..|  .|.:|           ||.... ::|||..:|...|||.:
 Frog   320 EEDELKPYVEP-----IPDYKDP--KRTEL-----------MITMGY-TREEISDSLVNQKYNEV 365

  Fly   334 TATYFLLAELRLRRRREELAQKQRLLNDASMKVGDASRKLVPEKPSPTEAQKGGVPISINVTPAA 398
            .|||.||.........:.|..|.|...|.:..:..:....|....|....|:   .:|....||.
 Frog   366 MATYLLLGYKSSETDNDNLTLKPRPPPDVTNSIAPSPAHKVQRSVSANPKQR---RLSDQAGPAI 427

  Fly   399 QFANDGGKPDKRSRKCSIVREEDEEESA---------------------TECTAVGNELKVTSSS 442
            ..:|...| ..:|......|.||::||.                     |..|...|.:..|.::
 Frog   428 PNSNSYSK-KTQSNNAENRRSEDDKESGRKSSSTVRVPPSPLSGLDRKKTTPTPSTNSVLSTGTN 491

  Fly   443 RREAFSDSPFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQMEKSAKI 507
            |..   :||    :.:|:|..||:...|:.  :...|. ||.. ..|..||.| :::|.:||
 Frog   492 RSR---NSP----MLDRASLVPGSVQNGKD--SFSTPG-SRAS-TASAPATSA-RIRQHQKS--- 541

  Fly   508 DEDTLSGLKELEIGKLKPLPSSSKNPVLTHRRTKLNKIRTPSCSSSEASDDDTKTRNKKKINKFV 572
                    ....:...||.||...|..:....|...::...|.|:...|...|:..|      |.
 Frog   542 --------MSTSVHPSKPAPSLDGNCEVQRPSTAPQRVPVASPSAHNISSAATERTN------FP 592

  Fly   573 GDTPVRFRMHR---RDSHDDSSDSQDQLYP--PPGSASN----AGNFISKSGSVSGKKEGQSQYK 628
            .....|...|.   |.:.|..:.....:.|  |.|::..    .|:..||..|...::....::.
 Frog   593 RGVSSRSTFHAGQVRQARDQQNLGFGSVSPASPSGNSQGRRGATGSIFSKFTSKFVRRNLSFRFP 657

  Fly   629 EPNNKSDENRKSHSQKNRKQHNKDHV-------DKHSHAERQLADSSTATTGNSTNRRRRIRESQ 686
            ..|....|.      |:|.:..:.|:       ||..|.:               ::.|.:|.:.
 Frog   658 RRNPNEPEG------KDRVESTRPHLTVLDKEKDKEDHRD---------------SKPRSLRFTW 701

  Fly   687 SLDRITEAQEYEMRHRCYAESEAASSSSSSTQHIDQ-RYSLLSLN 730
            |:...:..:..||........:|     ::.||..| :|.||.::
 Frog   702 SMKTTSSMEPNEMMSEIRKVLDA-----NNCQHESQEKYMLLCVH 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	129/263 (49%)
		UBA_SNRK	296..338	CDD:270524	12/41 (29%)
mark2	XP_012808991.1	STKc_MARK	63..315	CDD:270974	127/253 (50%)
		UBA_MARK2	333..374	CDD:270589	17/54 (31%)
		MARK2_C	693..791	CDD:213386	12/54 (22%)