DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8485 and SNRK

DIOPT Version :9

Sequence 1:	NP_610942.2	Gene:	CG8485 / 36579	FlyBaseID:	FBgn0033915	Length:	860	Species:	Drosophila melanogaster
Sequence 2:	NP_001094064.1	Gene:	SNRK / 54861	HGNCID:	30598	Length:	765	Species:	Homo sapiens

Alignment Length:	886	Identity:	356/886 - (40%)
Similarity:	458/886 - (51%)	Gaps:	239/886 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DGKIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHP 77
            ||||||||||::|||.|||||||||||||||.||||||:||||||.::..|||||||||||||||
Human     9 DGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

  Fly    78 NVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHR 142
            |:|||||||||||||||:||||||||::||||||:.||:|:||:|||.||:.||:|||:||||||
Human    74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHR 138

  Fly   143 DLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGV 207
            ||||||||||||.||||||||||||||.||:||.|.|||||||||||||||.|||||||||||||
Human   139 DLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGV 203

  Fly   208 ILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAW 272
            ||:||||||.||::||||||||||||||||||||||.:|:|||..||.||||:||::|||.:..|
Human   204 ILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIENHPW 268

  Fly   273 LKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQALDKNKYNHITATY 337
            |:.:|...:|    ::.:||||.:.|.||:|..|||:|:.|:||.::.|::||:.|:||||||||
Human   269 LQGVDPSPAT----KYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATY 329

  Fly   338 FLLAELRLRRRREELAQ-----------------------KQRLLNDASMKVGDASRKLVPEKPS 379
            |||||..||.::|:..|                       .|.|.:|  :.....|...||:.|:
Human   330 FLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDD--LTATPLSHATVPQSPA 392

  Fly   380 PT---------------EAQKGGVP----ISINVTPAAQFANDGGKPDKRSRKCSIVREEDEEES 425
            ..               .|:|..:|    .:::..|.|..     ||....|||....||||||.
Human   393 RAADSVLNGHRSKGLCDSAKKDDLPELAGPALSTVPPASL-----KPTASGRKCLFRVEEDEEED 452

  Fly   426 ATE------CTAVGNELKVTSSSRREAFSDSPFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRT 484
            ..:      .|.|....|.:.::|..:...:|....|.|...|:.
Human   453 EEDKKPMSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDD-------------------- 497

  Fly   485 KIVVSVDATLAHKLKQMEKSAKIDEDTLSGLKELEIGKLKPLPSSSKNPVLTHRRTKLNKI--RT 547
              ...:|..|..||.:::.:.                         .:|...|:|....|.  |.
Human   498 --EFDMDENLPPKLSRLKMNI-------------------------ASPGTVHKRYHRRKSQGRG 535

  Fly   548 PSCSSSEASDDDTKTRNKKKINKFVGDTPVRFRMHRRDSHDDSSDSQDQLYPPPGSASNAGNFIS 612
            .||||||.||||:::|  ::::|   |:...:..|||||.:.          ||||..:.|
Human   536 SSCSSSETSDDDSESR--RRLDK---DSGFTYSWHRRDSSEG----------PPGSEGDGG---- 581

  Fly   613 KSGSVSGKKEGQSQYKEPNNKSDENRKSHSQKNRKQHNKDHVDKHSHAERQL--ADSSTATTGNS 675
                      |||   :|:|.|                 ..|||.|.:|...  ...|:.:.||.
Human   582 ----------GQS---KPSNAS-----------------GGVDKASPSENNAGGGSPSSGSGGNP 616

  Fly   676 TNRRRRIRESQSLDRITEAQEYEMRHRCYAESEAASSSSSSTQHIDQRYSLLSL----------- 729
            ||.....|                  ||...|.:...:|.|...:.:...|:||
Human   617 TNTSGTTR------------------RCAGPSNSMQLASRSAGELVESLKLMSLCLGSQLHGSTK 663

  Fly   730 ------NTSTFSVAETKEE-------------------------YDEEADATNATDQIMNTLNAA 763
                  |..:||..:.:|:                         .|..||.|...::|
Human   664 YIIDPQNGLSFSSVKVQEKSTWKMCISSTGNAGQVPAVGGIKFFSDHMADTTTELERI------- 721

  Fly   764 KATLQQEQYFNNNT--------NLSRNFNHNHNQSIIHISS 796
                 :.:...||.        .:|.|...|..:.::..||
Human   722 -----KSKNLKNNVLQLPLCEKTISVNIQRNPKEGLLCASS 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8485	NP_610942.2	STKc_SNRK	16..273	CDD:270976	209/256 (82%)
		S_TKc	20..273	CDD:214567	205/252 (81%)
		UBA_SNRK	296..338	CDD:270524	22/41 (54%)
SNRK	NP_001094064.1	STKc_SNRK	12..269	CDD:270976	209/256 (82%)
		S_TKc	16..269	CDD:214567	205/252 (81%)
		UBA_SNRK	288..335	CDD:270524	27/46 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	512..634		48/213 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155260
Domainoid	1	1.000	438	1.000	Domainoid score	I564
eggNOG	1	0.900	-	-		E1_KOG4717
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1133
Isobase	1	0.950	-	0	Normalized mean entropy	S1997
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006207
OrthoInspector	1	1.000	-	-		oto89203
orthoMCL	1	0.900	-	-		OOG6_101664
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3287
SonicParanoid	1	1.000	-	-		X4483
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.730