Protein Alignment Snrk and MARK1

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_001273053.1
• Gene: MARK1 / 4139
• HGNCID: 6896
• Length: 796
• Species: Homo sapiens
• Alignment Length: 760
• Identity: 228/760 - (30%)
• Similarity: 353/760 - (46%)
• Gaps: 154/760 - (20%)

  Fly    18 GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHPNVVRL 82
            |.|.|::|:|.|:||.|||||||.||.:||||::|||:|:..|...||:|||.||::.|||:|:|
Human    58 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKL 122

  Fly    83 YEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPE 147
            :|||:|:..||||:|...||:::||::.| ..:.|:.||..||||:.|:.||||.::||||||.|
Human   123 FEVIETEKTLYLVMEYASGGEVFDYLVAH-GRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAE 186

  Fly   148 NVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYML 212
            |::....:. :|:.||||||:|..|.||:|||||..|:|||:..|..||.|.||:||||||||.|
Human   187 NLLLDGDMN-IKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 250

  Fly   213 VCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAW----- 272
            |.|..||:..|..|....::..||.:|.::||||.:|:..:||.:|.||.::|:|....|
Human   251 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGH 315

  Fly   273 ----LKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQALDKNKYNHI 333
                |||..|||...:.::.                  |..|:....| ::||..||...||:.:
Human   316 EEEELKPYTEPDPDFNDTKR------------------IDIMVTMGFA-RDEINDALINQKYDEV 361

  Fly   334 TATYFLLAELRLRRRRE----------ELAQKQRL---LNDASMKVGDASRKLVPEKPSPTEAQK 385
            .|||.||.    |:..|          .|.|:.|.   ||::::           :.|:..:.|:
Human   362 MATYILLG----RKPPEFEGGESLSSGNLCQRSRPSSDLNNSTL-----------QSPAHLKVQR 411

  Fly   386 GGVPISIN-------------VTPAAQFANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELK 437
            .   ||.|             :.||..:.       ||.:..|:..|:.||....    |..:|.
Human   412 S---ISANQKQRRFSDHAGPSIPPAVSYT-------KRPQANSVESEQKEEWDKD----VARKLG 462

  Fly   438 VTSSSRREAFSDSPFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQME 502
            .|:...:...:.||......::||:.|.|     .:.:.|  |.:|....|....|..:...|..
Human   463 STTVGSKSEMTASPLVGPERKKSSTIPSN-----NVYSGG--SMARRNTYVCERTTDRYVALQNG 520

  Fly   503 KSAKIDEDTLSGLKELEIGKLKPLP----------SSSKNPVLTHRRTKLNKIRTPSC-SSSEAS 556
            |.:.:.|.::|.:..........:|          |:|.:|:         |:..|:. ..|||.
Human   521 KDSSLTEMSVSSISSAGSSVASAVPSARPRHQKSMSTSGHPI---------KVTLPTIKDGSEAY 576

  Fly   557 DDDTKTRN----KKKINKFVGDTPVRFRMHRRDSHDDSSDSQDQLY---------PPPGSASNAG 608
            ...:.|:.    ....:.....||.|.|. .|.|...|:...:||.         ||...:...|
Human   577 RPGSTTQRVPAASPSAHSISTATPDRTRF-PRGSSSRSTFHGEQLRERRSVAYNGPPASPSHETG 640

  Fly   609 NFI-SKSGSVSG-------------KKEGQSQYKEPNNKSDENRKSHSQ-KNR-KQHNKDHVDKH 657
            .|. ::.|:.:|             ..||     |.:.::|.:|.:..: |.| |:..||...:.
Human   641 AFAHARRGTSTGIISKITSKFVRRDPSEG-----EASGRTDTSRSTSGEPKERDKEEGKDSKPRS 700

  Fly   658 SHAERQLADSSTATTGNSTNRRRRIRESQSLDRITEAQEYEMRHR 702
            ......:..:|:....:.....|::.::.:.|       ||.:.|
Human   701 LRFTWSMKTTSSMDPNDMMREIRKVLDANNCD-------YEQKER 738

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	129/263 (49%)
		UBA_SNRK	296..338	CDD:270524	11/41 (27%)
MARK1	NP_001273053.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40
		STKc_MARK	59..311	CDD:270974	127/253 (50%)
		UBA_MARK1	331..371	CDD:270588	14/62 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..495		27/147 (18%)
		MARK1-3_C	697..794	CDD:213381	6/49 (12%)