Protein Alignment Snrk and melk

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_996771.2
• Gene: melk / 30724
• ZFINID: ZDB-GENE-990603-5
• Length: 676
• Species: Danio rerio
• Alignment Length: 683
• Identity: 201/683 - (29%)
• Similarity: 308/683 - (45%)
• Gaps: 122/683 - (17%)

  Fly     7 PVGGVSDGKIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKL-DDVSKAHLFQEVRC 70
            ||...|:  :...|::.||:|||.||.|||.||..||.|||:|:::|..| ||:.:..:  |:..
Zfish     2 PVDSTSE--LLRHYEVYETIGSGGFAKVKLGRHKLTGEKVAIKIMEKKDLGDDLPRVKI--EIEA 62

  Fly    71 MKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCH 135
            ||.:.|.:|.|||.||:|.:|:|:|||...||:|:|||:..|. ||||..|.:||||:.|:.|.|
Zfish    63 MKNLSHQHVCRLYHVIETTSKIYMVLEYCPGGELFDYIIAKDR-LSEEETRVFFRQIISALAYVH 126

  Fly   136 QLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLP----GQKLETFCGSLAYSAPEILLGDSYD 196
            .....||||||||::..|...| ||.|||...|  |    |.:|.|.|||.||:|||::.|.:|.
Zfish   127 SQGYAHRDLKPENLLIDEDHNL-KLIDFGLCAK--PKGGLGFELLTCCGSPAYAAPELIQGKAYI 188

  Fly   197 APAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKR 261
            ....|:||:||:||.|:||..||:..|.......|...||:.|..:|.....|:..|:..|||:|
Zfish   189 GSEADVWSMGVLLYALLCGFLPFDDDNCMVLYRKITRGKYSNPHWLSPSSILLLNQMMQVDPKRR 253

  Fly   262 ATVEEIASSAWLKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQALD 326
            .||:.:....|..    ...:|....|     |:..||..|...|.:..:... .||:..:|.:.
Zfish   254 LTVKHLLDHPWAM----RGYSTPVEWH-----SKYPLGHIDEDCITEMAVTFK-QSKQRTIQLVS 308

  Fly   327 KNKYNHITATYFLLAELRLRRRREELAQKQRLLNDASMKVGDASRKLVPEKPSPTEAQKGGVPIS 391
            :.||:.|||||.||...:.:.|...|..:..:::.....:.|...|   :....||...|..|:.
Zfish   309 EWKYDQITATYLLLLAKKRQGRPVRLRAECPVIDIVCSPLQDMQLK---KSLRFTEDDDGVHPVV 370

  Fly   392 IN--VTPAAQFANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTSSSRREAFSDSPFSR 454
            :.  |.|          ||     |     .|:|...|..|.  .....|::.|.:.:
Zfish   371 LGSMVFP----------PD-----C-----YDDENPWTPLTP--KNTHTTNTPRMKLY------- 406

  Fly   455 SIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQMEKSAKIDED-TLSGLKEL 518
                     |....|..::|.|.|..|||         ....|.::.:::.:..|: .:.|..
Zfish   407 ---------PETTEKWNEMAYSPVIEHSR---------PCRQKPERRDRTKENKENLAVPGTD-- 451

  Fly   519 EIGKLKPLPSSSKNPVLTHRRTKLNK--IRTPSCSSSEASDDDTKTRNKKKINKFVGDTPVRFRM 581
              |.:..|| :.:.|. :.|:.|.|:  :.||:.:::::|:          :||..| :..:...
Zfish   452 --GDVFALP-APRTPT-SSRKVKSNRTVMTTPNHNNNKSSE----------VNKGAG-SATKEGS 501

  Fly   582 HRRDSHDDSSDSQDQL----YPP---------PGSASNAGNFISKSGSVSGKKE----------G 623
            .||:.....:..|.:|    :.|         .|...::|. ..|.|.|.|..|          .
Zfish   502 RRREVEQQQNGQQGELNMLAFSPERRSRSLDLAGCQVDSGQ-KRKGGKVFGSLERGLDKVITMLT 565

  Fly   624 QSQYKEPNNKSDENRKSHSQKNRKQHNKDHVDK 656
            .|:.:.|.   |..||..:|.|....|:.:.|:
Zfish   566 PSKKRGPR---DGPRKIKAQYNVTLTNQTNADQ 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	114/261 (44%)
		UBA_SNRK	296..338	CDD:270524	13/41 (32%)
melk	NP_996771.2	STKc_MELK	9..264	CDD:270980	114/260 (44%)
		UBA_MELK	283..334	CDD:270526	15/51 (29%)
		UBA-like. /evidence=ECO:0000250	284..323		13/39 (33%)
		Autoinhibitory region. /evidence=ECO:0000250	328..673		64/339 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..518		22/120 (18%)
		MELK_C	577..671	CDD:213383	6/19 (32%)