Protein Alignment Snrk and SIK3

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_001353615.1
• Gene: SIK3 / 23387
• HGNCID: 29165
• Length: 1369
• Species: Homo sapiens
• Alignment Length: 932
• Identity: 240/932 - (25%)
• Similarity: 401/932 - (43%)
• Gaps: 184/932 - (19%)

  Fly     4 ETQPVGGVSDGKI---AGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLF 65
            :.:|....|.|.:   .|.|:::.|:|.|:|||||.|.|:.|.||||:|::|||:||:.:...:|
Human    47 QPRPPAPASRGPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIF 111

  Fly    66 QEVRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRA 130
            :||:.||::.||:::|||:|::|:..:|||.|...||:::|:::.| ..::|:.||:.|:||:.|
Human   112 REVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIFDHLVAH-GRMAEKEARRKFKQIVTA 175

  Fly   131 ITYCHQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSY 195
            :.:||..::||||||.||::....|. :|:.||||||.|.|||.|:|:|||..|:|||:..|..|
Human   176 VYFCHCRNIVHRDLKAENLLLDANLN-IKIADFGFSNLFTPGQLLKTWCGSPPYAAPELFEGKEY 239

  Fly   196 DAPAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKK 260
            |.|.||||||||:||:||||..||:.:........::..|:.:|..:||:|..||..|||.||.|
Human   240 DGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVLDPNK 304

  Fly   261 RATVEEIASSAWLKPIDEPDSTTSTSEHFLPLVSR-EQLGEEDHAFIIQKMINGNI--------A 316
            |.::|:|....|:|..|       ...:|..|::. :||.||...    ..:|.::        .
Human   305 RLSMEQICKHKWMKLGD-------ADPNFDRLIAECQQLKEERQV----DPLNEDVLLAMEDMGL 358

  Fly   317 SKEEILQALDKNKYNHITATYFLLAELRLRRRREELAQKQRLLNDASMKVG---DASRKLVPEKP 378
            .||:.||:|..:.|:|.:|.|.||.:   |.:|.:           ::::|   ...|.|..:.|
Human   359 DKEQTLQSLRSDAYDHYSAIYSLLCD---RHKRHK-----------TLRLGALPSMPRALAFQAP 409

  Fly   379 SPTEAQKGGVPISINVTPAAQFANDGG---KPDKRSRKCSIVREEDEEESATECTAVGNELKVTS 440
            ...:|::.|..::|:| |..|..|...   :||......|...||...|:.....::.......:
Human   410 VNIQAEQAGTAMNISV-PQVQLINPENQIVEPDGTLNLDSDEGEEPSPEALVRYLSMRRHTVGVA 473

  Fly   441 SSRREAFSDSPFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQMEK-- 503
            ..|.|...|      :.:.....||        .|...|.     :.|:.:....|.|..|:.
Human   474 DPRTEVMED------LQKLLPGFPG--------VNPQAPF-----LQVAPNVNFMHNLLPMQNLQ 519

  Fly   504 ---SAKIDEDTLSGLKELEI----GKLKPLPSSSKNPVLTHRRTKLNKIRTPSC----------- 550
               ..:..|.:|.....|::    |.|....|.....:..|.:..|.:.|.||.
Human   520 PTGQLEYKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAV 584

  Fly   551 ------SSSEASDDDTKTR---NKKK----------------INKFVGDTPVRFRM---HR-RDS 586
                  ||....|.:...|   |:.|                :.:.:|..|.|.|:   |. .|.
Human   585 TPVDEESSDGEPDQEAVQRYLANRSKRHTLAMTNPTAEIPPDLQRQLGQQPFRSRVWPPHLVPDQ 649

  Fly   587 HDDSSDSQDQLYPPPGSASNAGNFISKSGSVSG------KKEGQSQYKEPNNKSDENRKSHS--- 642
            |..:....:.|:.|....|....|...:.|:..      |....|..|:...:.::.:|.:.
Human   650 HRSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQI 714

  Fly   643 -----QKNRKQH----NKDHVDKHSHAERQLADS---------STATTGNS----TNRRRRIRES 685
                 :|.::||    .:.|   |...::|:.||         ..|...|.    |::.:|:|..
Human   715 DERTLEKTQQQHMLYQQEQH---HQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQ 776

  Fly   686 QSLDRITEAQEYEMRHRCYAESEAAS--------SSSSSTQHIDQRYSLLSLN----TSTFSVAE 738
            .|.........:..|....:....:|        :|||..|.:..|.::....    :|..:||.
Human   777 PSSPPPNHPNNHLFRQPSNSPPPMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVAL 841

  Fly   739 TKEEYDEEADATNATDQIMN--------------------TLNAAKATLQQEQYFNNNTNLSRNF 783
            |.....:.|.:...|.|:..                    :::.:...:|.:    :.|||....
Human   842 TCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTAAGSSGRGISISPSAGQMQMQ----HRTNLMATL 902

  Fly   784 NHNHNQSIIHISSQKANGKKSN 805
            ::.|......:|:..|.....|
Human   903 SYGHRPLSKQLSADSAEAHSLN 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	117/259 (45%)
		UBA_SNRK	296..338	CDD:270524	13/49 (27%)
SIK3	NP_001353615.1	STKc_SIK	65..317	CDD:270973	116/253 (46%)
		UBA_SIK3	346..390	CDD:270593	14/46 (30%)