DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Snrk and MARK2

DIOPT Version :10

Sequence 1:NP_610942.2 Gene:Snrk / 36579 FlyBaseID:FBgn0033915 Length:860 Species:Drosophila melanogaster
Sequence 2:NP_001034558.2 Gene:MARK2 / 2011 HGNCID:3332 Length:788 Species:Homo sapiens


Alignment Length:764 Identity:228/764 - (29%)
Similarity:353/764 - (46%) Gaps:128/764 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHPNVVRL 82
            |.|.|.:|:|.|:||.||||||:.||.:||||::|||:|:..|...||:|||.||::.|||:|:|
Human    51 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKL 115

  Fly    83 YEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPE 147
            :|||:|:..||||:|...||:::||::.| ..:.|:.||..||||:.|:.||||..:||||||.|
Human   116 FEVIETEKTLYLVMEYASGGEVFDYLVAH-GRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAE 179

  Fly   148 NVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYML 212
            |::....:. :|:.||||||:|..|.||:|||||..|:|||:..|..||.|.||:||||||||.|
Human   180 NLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 243

  Fly   213 VCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAWLKPID 277
            |.|..||:..|..|....::..||.:|.::||||.:|:...|:.:|.||.|:|:|....|:....
Human   244 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGH 308

  Fly   278 EPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQALDKNKYNHITATYFLLAE 342
            |.|       ...|.|  |.|.:.......:.|::... ::|||..:|...:||.:.|||.||..
Human   309 EDD-------ELKPYV--EPLPDYKDPRRTELMVSMGY-TREEIQDSLVGQRYNEVMATYLLLGY 363

  Fly   343 LRLRRRREELAQKQR----LLNDASMKVGDASRKLVPEKPS----PTEAQKGGVPISINVTPAAQ 399
            .......:.:..|.|    |.|.::.......::.|...|.    ..:|....:|.|.:.:...|
Human   364 KSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRFSDQAAGPAIPTSNSYSKKTQ 428

  Fly   400 FANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTSSS----RREAFSDSPFSRSIHERS 460
            ..|...|           |.|::.||..:.::..   ||.:|.    .|:..:.:|.:.|:...|
Human   429 SNNAENK-----------RPEEDRESGRKASSTA---KVPASPLPGLERKKTTPTPSTNSVLSTS 479

  Fly   461 SSEPGNQ------TKGEQIANSGVPS----HSRTKIVVSVDATLAHKLKQMEK--SAKIDEDTLS 513
            ::...|.      :.|:....:|..|    .||.....:..|..|.:.:|.:|  ||.:..:..|
Human   480 TNRSRNSPLLERASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKAS 544

  Fly   514 GLKELEIGKLKPLPSSSKNPVLTHRRTKLNKIRTPSC---SSSEASDDDT--------------- 560
            ||...|.....|.||::...|         .:.:||.   |||..:.|.|               
Human   545 GLPPTESNCEVPRPSTAPQRV---------PVASPSAHNISSSGGAPDRTNFPRGVSSRSTFHAG 600

  Fly   561 ---KTRNKKKINKFVGDTPVRFRMHRRDSHDDSSDSQDQLYPPPGSASNAGNFISKSGSVSGKKE 622
               :.|:::  |...|.||.          ..|..||       |....:|:..||..|...::.
Human   601 QLRQVRDQQ--NLPYGVTPA----------SPSGHSQ-------GRRGASGSIFSKFTSKFVRRN 646

  Fly   623 GQSQYKEPNNKSDENRKSHSQKNRKQHNKDHV------DKHSHAERQLADSSTATTGNSTNRRRR 681
            ...::...|....|:      |:|.:..:.||      ||.....|:.             :.|.
Human   647 LSFRFARRNLNEPES------KDRVETLRPHVVGSGGNDKEKEEFREA-------------KPRS 692

  Fly   682 IRESQSLDRITEAQEYEMRHRCYAESEAASSSSSSTQHIDQRYSLLSLN 730
            :|.:.|:...:..:..||..    |......::|....:.::|.||.::
Human   693 LRFTWSMKTTSSMEPNEMMR----EIRKVLDANSCQSELHEKYMLLCMH 737

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SnrkNP_610942.2 STKc_SNRK 16..273 CDD:270976 127/254 (50%)
UBA_SNRK 296..338 CDD:270524 11/41 (27%)
MARK2NP_001034558.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46
STKc_MARK 52..304 CDD:270974 126/253 (50%)
UBA_MARK2 322..363 CDD:270589 12/41 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 373..632 59/300 (20%)
MARK2_C 689..787 CDD:213386 10/53 (19%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.