Protein Alignment Snrk and kin-29

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_508493.1
• Gene: kin-29 / 180574
• WormBaseID: WBGene00002210
• Length: 822
• Species: Caenorhabditis elegans
• Alignment Length: 824
• Identity: 209/824 - (25%)
• Similarity: 338/824 - (41%)
• Gaps: 167/824 - (20%)

  Fly    18 GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHPNVVRL 82
            ||||:...:|.|:||.|::|||.....|||:|.:|.:.||..:...|.:||:.:|::.||::|:.
 Worm    14 GLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVKIVKVIDHPHIVKS 78

  Fly    83 YEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPE 147
            ||::.....||:|.|....|:||:.::: ...::|.:|||:|.:...|:.|.|...:||||||.|
 Worm    79 YEIMRVDNMLYIVSEYCSSGELYETLIE-KGRVAENVARKWFSETASAVAYLHSQGIVHRDLKAE 142

  Fly   148 NVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYML 212
            |:: ..|...:|:.||||||.....|.|.|:|||..|:|||:|||:|||....||||:||:||:|
 Worm   143 NIL-LGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLYIL 206

  Fly   213 VCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAWLKPID 277
            |.|..||...:.::....::.....:|..||.:|.|.|..|||.:|.||.|::.:....|:...|
 Worm   207 VAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWMHIRD 271

  Fly   278 EPDSTTSTS-EHFLPLVSRE--QLGEEDHAFIIQKMINGNIASKEEILQA-LDKNKYNHITATYF 338
            :.....:.. ...:|..|.|  |...:.:..|:..|......|:|:|:.| |.::..:.|.|||.
 Worm   272 DVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIIDAVLGRDFESPIFATYE 336

  Fly   339 LLAEL----RLRRRREELAQKQRLLNDASMKVGDASRKLVPEKP-SPTEAQKGGVPISINVTPAA 398
            |||:.    .|....||..::.   :..|:..|.|:   |.|:| :||          |:....|
 Worm   337 LLADKVKKGTLEGTGEEFPRRG---SRGSILSGKAN---VDEQPLTPT----------ISAHQLA 385

  Fly   399 QFANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTSSSRREAFSDSPFSR---SIHERS 460
            |.                      ..|:.:|.:       ..||..:...|||.|.   ..|||.
 Worm   386 QL----------------------NLSSPDCDS-------DDSSNSDLCDDSPMSSMGPMNHERQ 421

  Fly   461 SSEP-GNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQMEKSAKIDEDTLS-----GLKELE 519
            ...| |....|.:..|       |...:.:.:..|:..:........:..:..|     |...:.
 Worm   422 FGTPHGLDIIGNRFEN-------RRHTLCASEQLLSPNMMGQFPPPNLLLNNFSMNPPLGFPPMP 479

  Fly   520 IGKLKPLPSSSKNPVL-THRRTKLNKIRTPSCSSSEASDDDTKTRNKKKINKFVGDTPVRFRMHR 583
            .|:....|..|.:|.. |.....|:|:.....|...||..:|.......:.:.:.:.|.
 Worm   480 EGQAAEFPLPSLHPAFATIPIADLSKMLPVPKSERRASAGETLLPTNFDLTQHLANLPA------ 538

  Fly   584 RDSHDDSSDSQDQLYPP---PGSASNAGNFISKSGSVSGKKE----------GQSQ------YKE 629
                           ||   |.......:::||.|   ||:.          |..|      .:.
 Worm   539 ---------------PPISFPTVEEEGKSYLSKYG---GKRNTVHCLGNQLGGGIQNPIPRYQRT 585

  Fly   630 PNNKSD--ENRKSHSQKNRKQHNKDHVDKHSHAERQLADSSTATTGNSTNRRRRIR--------- 683
            |..|:.  |.|.|.:..:.....::|::|       |...:..|..:.|...:..:
 Worm   586 PYTKAPPAERRSSWASPSLSAQQQNHLEK-------LFKQALQTNNDMTRLHKEFKGLSHGCAQS 643

  Fly   684 ----ESQSL--DRITEAQEYEMRHRCYAESEAASSSSSSTQHIDQR-----------YSLLSLNT 731
                |..||  .:|:...||..:|..     |.|:||.....|.|:           .:.:..::
 Worm   644 QITNEGSSLACPQISITDEYNRQHNI-----APSASSFDPVSIFQKNAQEVVFGQRPATAIGFSS 703

  Fly   732 STFSVAETKEEYDEEAD-----------ATNATDQIMNTLNAAK 764
            ::||...|.|:.....|           .|...|::..:||..|
 Worm   704 TSFSGMSTPEQTTRSIDDRVRSIVCTLPFTEVIDELKASLNILK 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	101/254 (40%)
		UBA_SNRK	296..338	CDD:270524	12/44 (27%)
kin-29	NP_508493.1	Protein Kinases, catalytic domain	16..267	CDD:473864	99/252 (39%)