Protein Alignment Snrk and Sik1

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_034961.2
• Gene: Sik1 / 17691
• MGIID: 104754
• Length: 779
• Species: Mus musculus
• Alignment Length: 704
• Identity: 203/704 - (28%)
• Similarity: 320/704 - (45%)
• Gaps: 161/704 - (22%)

  Fly    18 GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHPNVVRL 82
            |.||:|.|||.|:|||||||||..|..:||:|::|||:||..:...:::||:.|||:.|||:::|
Mouse    25 GFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPNIIKL 89

  Fly    83 YEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPE 147
            |:|::|:..||:|.|....|:::||:.. :..|||..||:.|.|||.|:.|||..|:||||||.|
Mouse    90 YQVMETKDMLYIVTEFAKNGEMFDYLTS-NGHLSENEARQKFWQILSAVEYCHNHHIVHRDLKTE 153

  Fly   148 NVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYML 212
            |::....:. :||.||||.|.:.||:.|.|:|||..|:|||:..|..|:.|.:|:|||||:||:|
Mouse   154 NLLLDSNMD-IKLADFGFGNFYKPGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVVLYVL 217

  Fly   213 VCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAWLKPID 277
            |||..||:..|.......:::.::.:|..:|.||..||..|||.||.||.|:.:|....|:
Mouse   218 VCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWM---- 278

  Fly   278 EPDSTTSTSEHFLPLVSREQLGEEDHAFIIQ----------KMINGNIAS----KEEILQALDKN 328
            :.|.|.              |.::|.||.:|          :.:.|.:.:    ::..:::|..:
Mouse   279 QADPTL--------------LQQDDPAFDMQGYTSNLGDYNEQVLGIMQALGIDRQRTIESLQNS 329

  Fly   329 KYNHITATYFLLAELRLRRRREELAQ----------KQRLLNDASMKVGDASRKLV---PEKPS- 379
            .|||..|.|:||.| ||:..|.  ||          :|..|..:.:...:..::::   |.:||
Mouse   330 SYNHFAAIYYLLLE-RLKEHRS--AQPSSRPTPAPTRQPQLRSSDLSSLEVPQEILPCDPFRPSL 391

  Fly   380 ------------------------------PTEAQKGGV-------PISINVTPAAQFANDGGK- 406
                                          |.:....||       |.|:..|..::.|..|..
Mouse   392 LCPQPQALAQSVLQAEIDCDLHSSLQPLLFPLDTNCSGVFRHRSISPSSLLDTAISEEARQGPSL 456

  Fly   407 ----------PDKRSRKCSIVREEDEEESATECTAVGNELKVTSSSRREAFSDSPFSRSIHERSS 461
                      |....|:.::.      |.:|..:.:.....:.|||...:.|:...|.|....|:
Mouse   457 EEEQEVQEPLPGSTGRRHTLA------EVSTHFSPLNPPCIIVSSSATASPSEGTSSDSCLPFSA 515

  Fly   462 SE-----------PG--NQTKGEQIANSGVPSHSRTKIV-------------VSV-------DAT 493
            ||           ||  ..:...::|:..:.|.|.|.::             ||.       |.:
Mouse   516 SEGPAGLGSGLATPGLLGTSSPVRLASPFLGSQSATPVLQTQAGLGTAVLPPVSFQEGRRASDTS 580

  Fly   494 LAHKLK----QMEKSAKIDEDTLSGLKELEIGKLKPL-----PSSSKNPVLTHRRTKLNKIRTPS 549
            |...||    |:.|:|:     ..|.  |.:.|:|.|     .||.:.|     |..::...||:
Mouse   581 LTQGLKAFRQQLRKNAR-----TKGF--LGLNKIKGLARQVCQSSVRTP-----RGGMSTFHTPA 633

  Fly   550 CSSSEASDDDTKTRNKKKINKFVGDTPVRFRMHRRDSHDDSSDSQD--QLYPPP 601
            .||.......:....:..:.:.:....:....|...:...||..|.  ||.|.|
Mouse   634 PSSGLQGCTTSNREGRSLLEEVLHQQRLLQLQHHSSTAAASSGCQQGPQLSPVP 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	118/254 (46%)
		UBA_SNRK	296..338	CDD:270524	11/55 (20%)
Sik1	NP_034961.2	STKc_SIK	26..278	CDD:270973	117/253 (46%)
		UBA_SIK1	300..349	CDD:270591	12/49 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..375		4/26 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..472		3/22 (14%)
		RK-rich region	586..612		9/32 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	621..641		6/24 (25%)