DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8485 and Snrk

DIOPT Version :9

Sequence 1:	NP_610942.2	Gene:	CG8485 / 36579	FlyBaseID:	FBgn0033915	Length:	860	Species:	Drosophila melanogaster
Sequence 2:	NP_620188.1	Gene:	Snrk / 170837	RGDID:	69653	Length:	746	Species:	Rattus norvegicus

Alignment Length:	770	Identity:	336/770 - (43%)
Similarity:	423/770 - (54%)	Gaps:	178/770 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DGKIAGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHP 77
            ||||||||||::|||.|||||||||||||||.||||||:||||||.::..|||||||||||||||
  Rat     9 DGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHP 73

  Fly    78 NVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHR 142
            |:|||||||||||||||:||||||||::||||||:.||:|:||:|||.||:.||:|||:||||||
  Rat    74 NIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHR 138

  Fly   143 DLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGV 207
            ||||||||||||.||||||||||||||.||:||.|.|||||||||||||||.|||||||||||||
  Rat   139 DLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGV 203

  Fly   208 ILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAW 272
            ||:||||||.||::||||||||||||||||||..||..|||||..||.||||:||::|||.|..|
  Rat   204 ILFMLVCGQPPFQEANDSETLTMIMDCKYTVPPRVSAGCRDLITRMLQRDPKRRASLEEIESHPW 268

  Fly   273 LKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQALDKNKYNHITATY 337
            |:.:|...:|    ::.:||||.:.|.||:|..|||:|:.|:||.::.|::||:.|:||||||||
  Rat   269 LQGVDPSPAT----KYNIPLVSYKNLSEEEHNSIIQRMVLGDIADRDAIVEALETNRYNHITATY 329

  Fly   338 FLLAELRLRRRREELAQ-----------------------KQRLLNDASMKVGDASRKLVPEKPS 379
            |||||..||.::|:..|                       .|.|.:|  :.....|...||:.|:
  Rat   330 FLLAERILREKQEKEIQTRSASPSNIKAQFRQSWPTKIDVPQDLEDD--LTATPLSHATVPQSPA 392

  Fly   380 PT---------------EAQKGGVP----ISINVTPAAQFANDGGKPDKRSRKCSIVREEDEEES 425
            ..               .|:|..:|    .:::..|.|..     ||....|||....||||||.
  Rat   393 RAGDSVLNGHRSKGLCDPAKKDELPELAGPALSTVPPASL-----KPAASGRKCLFRVEEDEEED 452

  Fly   426 ATE------CTAVGNELKVTSSSRREAFSDSPFSRSIHERSSSEPGNQTKGEQIANSGVPSHSRT 484
            ..:      .|.|....|.:.::|..:...:|....|.|...|:.
  Rat   453 EEDKKPVSLSTQVVLRRKPSVTNRLTSRKSAPVLNQIFEEGESDD-------------------- 497

  Fly   485 KIVVSVDATLAHKLKQMEKSAKIDEDTLSGLKELEIGKLKPLPSSSKNPVLTHRRTKLNKI--RT 547
              ...:|..|..||.:::.:.                         .:|...|:|....|.  |.
  Rat   498 --EFDMDENLPPKLSRLKMNI-------------------------ASPGTVHKRYHRRKSQGRG 535

  Fly   548 PSCSSSEASDDDTKTRNKKKINKFVGDTPVRFRMHRRDSHDDSSDSQDQLYPPPGSASNAGNFIS 612
            .||||||.||||:::|  ::::|   |:.:.:..|||||.:.          ||||..:.|
  Rat   536 SSCSSSETSDDDSESR--RRLDK---DSGLAYSWHRRDSSEG----------PPGSEGDGG---- 581

  Fly   613 KSGSVSGKKEGQSQYKEPNNKSDENRKSHSQKNRKQHNKDHVDKHSHAERQLADSSTATTGNSTN 677
                      |||                     |......|||.|..|:....|....:|.
  Rat   582 ----------GQS---------------------KPSGGGGVDKASPGEQGTGGSGQGGSGG--- 612

  Fly   678 RRRRIRESQSLDRITEAQEYEMRHRCYAESEAASSSSSST---QHIDQRYSLLSL 729
                          |.:.......||.....::||.:|:.   ..:.|...|:||
  Rat   613 --------------TPSGTAGSSRRCAGPDSSSSSPASAAPRGAELVQSLKLVSL 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8485	NP_610942.2	STKc_SNRK	16..273	CDD:270976	209/256 (82%)
		S_TKc	20..273	CDD:214567	205/252 (81%)
		UBA_SNRK	296..338	CDD:270524	22/41 (54%)
Snrk	NP_620188.1	STKc_SNRK	12..269	CDD:270976	209/256 (82%)
		UBA_SNRK	288..335	CDD:270524	27/46 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..414		5/30 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..638		50/257 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349145
Domainoid	1	1.000	434	1.000	Domainoid score	I556
eggNOG	1	0.900	-	-		E1_KOG4717
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1114
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006207
OrthoInspector	1	1.000	-	-		oto96324
orthoMCL	1	0.900	-	-		OOG6_101664
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4483
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.750