Protein Alignment Snrk and Sik3

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: XP_061505498.1
• Gene: Sik3 / 1277022
• VectorBaseID: AGAMI1_013806
• Length: 1690
• Species: Anopheles gambiae
• Alignment Length: 774
• Identity: 204/774 - (26%)
• Similarity: 340/774 - (43%)
• Gaps: 161/774 - (20%)

  Fly     4 ETQPVGGVSDGKI--AGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQ 66
            :.|..|.:|..|:  .|.|:||:|:|.|:|||||||.:|.|.:|||:|::|||.||:.:.|..|:
Mosquito    46 QQQQPGAMSIEKLVRVGYYELEKTIGKGNFAVVKLASNVITNSKVAIKIIDKTCLDEENLAKTFR 110

  Fly    67 EVRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAI 131
            |:..:|::.||::.|||||::::.|:|||.|....|:::|:::. :..:.||.|.:.|.||:.|:
Mosquito   111 EISILKVLHHPHITRLYEVMESRNKIYLVTEHAAQGEIFDHLVA-NGRMREEEAARIFSQIVAAV 174

  Fly   132 TYCHQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYD 196
            .|||:..:||||||.|||:....:. |||.||||||.|:.||.|.|:|||..|:|||:..|..||
Mosquito   175 DYCHRKGIVHRDLKAENVLLDTDMN-VKLADFGFSNTFVEGQPLRTWCGSPPYAAPEVFQGVEYD 238

  Fly   197 APAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKR 261
            .|..|||||||:||:||||..||:.....:..::::..|:.:|..:|.:|..||..|||.:|::|
Mosquito   239 GPKSDIWSLGVVLYVLVCGALPFDGTTLHDLRSVVVAGKFRIPFFMSQECEQLIRHMLVVEPERR 303

  Fly   262 ATVEEIASSAWLKPIDEPDSTTSTSEHFLPLVSREQLG------------EEDHAFIIQKMINGN 314
            .|:::||...||...:.           :|::.....|            |.....::..|:...
Mosquito   304 YTLKQIAHHRWLAQYNS-----------IPMLEAGDYGLGSAGGPVVRETENLDTVVMTHMLQLP 357

  Fly   315 IASKEEILQALDKNKYNHITATYFLLAELRLRRRREELAQKQRLLNDASMKVGDASRKLVP---- 375
            ..:.:.|.|::.:::::||.|.|.||.: :||::|:|   |.||.:.||:....:.:..:.
Mosquito   358 GLTADMIAQSVHESRFDHIYAIYNLLVD-KLRQKRKE---KGRLQHHASLAYSRSRKTSITTGVV 418

  Fly   376 -----------EKPSPTEAQKGGVPISIN-----------------VTPAAQFANDGGKPDKRSR 412
                       |:.||. ...|...::|:                 .||.      ||.|.::|.
Mosquito   419 DRTEVIKNDSLERLSPL-TSVGSTILNISSGLAGSEELEKYDQDTATTPT------GGAPARQSD 476

  Fly   413 KCSIVREEDEEESATECTAVGNELKVTSSSRREAFSDSPF-SRSIHERSSSEPGNQTKGEQIANS 476
            ..:.:..:.::          ::.:.....:::.:....| ..|.|..:.:..|...........
Mosquito   477 VGTTLGSDQQQ----------HQQQHPQHQQQQQYQQHLFPPPSCHGANGAGGGGGNTRRHTVGP 531

  Fly   477 GVPSHSRTKI---VVSVDATLAHKLKQMEKSAKIDEDTLSGLKELEIGKLKP-----------LP 527
            |..:|.:..:   ||.:                          ..:||..:|           :|
Mosquito   532 GDVAHEQVLVNPNVVPI--------------------------SFKIGPHEPPVPPTPNVPINIP 570

  Fly   528 SSSKNPV--LTHRRTKLNKIRTPSCSSSEASDDDTKTRNKKKINKFVGDTPVRFRMHRRDSH--- 587
            |....|:  ||.:...|  ::.|:...:.:|.....:.....:..:...:...|. .:..||
Mosquito   571 SLQNQPIHNLTIKDQHL--LKPPTVMGATSSFGRRASDGGANLQIYYPSSSTNFH-DQHHSHQQQ 632

  Fly   588 -----DDSSDSQDQLYPPPGSASNAGNFISKSGSVSGKKEGQS-------QYKEPNNK-----SD 635
                 ...|..|.|.....||...|....|..|.:||.....:       ..:.||::     :|
Mosquito   633 PQQPQSQQSQQQSQQQQGDGSLLGASGPTSALGPISGAVNNSTLMMDHVMMLQTPNSEGTDDSND 697

  Fly   636 E-NRKSHSQKNRKQHNKDHVD--------------KHSHAERQLADSSTATTGNSTNRR 679
            | .|..|.:...|:|.....|              .||.|......|||...|....||
Mosquito   698 EIQRYMHGRGCTKRHTVGCTDDLSAGNASPMEPPQAHSPAPSAGGTSSTGAGGGGRTRR 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	116/258 (45%)
		UBA_SNRK	296..338	CDD:270524	8/53 (15%)
Sik3	XP_061505498.1	None