Protein Alignment Snrk and AMPKalpha

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: XP_312237.4
• Gene: AMPKalpha / 1273276
• VectorBaseID: AGAMI1_005037
• Length: 565
• Species: Anopheles gambiae
• Alignment Length: 653
• Identity: 171/653 - (26%)
• Similarity: 269/653 - (41%)
• Gaps: 185/653 - (28%)

  Fly     5 TQPVGGVSDGKI-AGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTK---LDDVSKAHLF 65
            :|| ||.....: .|.|.|..|||:|.|..||:..|..|..|||||::::.|   ||.|.|  :.
Mosquito     6 SQP-GGTPQPLVKIGHYILGATLGTGSFGKVKIGEHQVTKHKVAVKILNRQKIKSLDVVGK--IR 67

  Fly    66 QEVRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRA 130
            :|::.:||.:||::::||:||.|.|.:::::|...||:|:|||:|:.. |.|..||::|:||:..
Mosquito    68 REIQNLKLFRHPHIIKLYQVISTPTDIFMIMEYVSGGELFDYIVKNGK-LQESEARRFFQQIISG 131

  Fly   131 ITYCHQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSY 195
            :.|||:..:|||||||||:: .:....||:.|||.||..|.|:.|.|.|||..|:|||::.|..|
Mosquito   132 VDYCHRHMIVHRDLKPENLL-LDHNRHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLY 195

  Fly   196 DAPAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCK---YTVPSHVSTDCRDLIASMLVRD 257
            ..|.|||||.|||||.|:||..||:   |....|:....|   :.:|.:::.....|:..||..|
Mosquito   196 AGPEVDIWSCGVILYALLCGTLPFD---DEHVPTLFRKIKSGVFPIPEYLNKQVVSLLCQMLQVD 257

  Fly   258 PKKRATVEEIASSAWLK----------PIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMIN 312
            |.||||||||....|.:          |:::..|...|:                   .|:::..
Mosquito   258 PLKRATVEEIKKHEWFQKDLPAYLFPSPVEQDSSVVDTN-------------------AIREVCE 303

  Fly   313 GNIASKEEILQA-LDKNKYNHITATYFLLAELRLRRRREELAQKQRLLNDASMKVGDASRKLVPE 376
            .....:.|:..| |..:.::.:...|.|:.:            .:|:.::|:.  .:.....|..
Mosquito   304 KFSVKEHEVHNALLSGDPHDQLAIAYHLIID------------NKRIADEAAK--AELKEFYVAG 354

  Fly   377 KPSPTEA-QKGGVPISINVTPAAQFANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTS 440
            .|.|..| .|.|.|:.    |.:......|.|.:
Mosquito   355 SPPPPGADSKFGTPLG----PGSIAPTQAGTPSE------------------------------- 384

  Fly   441 SSRREAFSDSPF-SRSIHERSSSEPGNQTKGEQIANSGVPSHSRTKIVVSVDATLAHKLKQMEKS 504
                      || |.|||.                                           |:.
Mosquito   385 ----------PFKSPSIHP-------------------------------------------ERI 396

  Fly   505 AKIDEDTLSGLKELEIGKLKPLPSSSKNPVLTHRRTKLNKIRTPSCSSSEASDDDTKT---RNKK 566
            |.:.|..::..:.:.:..|..:..|:..|:..||.|.:.:.:......|::..:|...   |..|
Mosquito   397 APLRERPVTAAQNMPVPTLSTMSPSAVMPIDKHRGTPVKRAKWHLGIRSQSKPNDIMLEVYRAMK 461

  Fly   567 KIN---KFVGDTPVRFRMH--RRDSH------------------------DDSSDSQD----QLY 598
            .::   |.:....||.|.:  |.|.|                        |:.....|    .|.
Mosquito   462 ALDFEWKIINPYHVRVRKYNARNDKHVKMSLQLYQVDPKNYLLDFKSLTNDEVEQGDDVIMESLT 526

  Fly   599 PPP 601
            |||
Mosquito   527 PPP 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	113/263 (43%)
		UBA_SNRK	296..338	CDD:270524	4/42 (10%)
AMPKalpha	XP_312237.4	STKc_AMPK_alpha	18..273	CDD:270981	113/261 (43%)
		UBA_AID_AMPKalpha	290..354	CDD:270521	11/96 (11%)
		AMPKA_C	436..563	CDD:213378	17/94 (18%)