Protein Alignment Snrk and Mark1

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: XP_038946210.1
• Gene: Mark1 / 117016
• RGDID: 619882
• Length: 794
• Species: Rattus norvegicus
• Alignment Length: 753
• Identity: 236/753 - (31%)
• Similarity: 359/753 - (47%)
• Gaps: 142/753 - (18%)

  Fly    18 GLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTKLDDVSKAHLFQEVRCMKLVQHPNVVRL 82
            |.|.|::|:|.|:||.|||||||.||.:||||::|||:|:..|...||:|||.||::.|||:|:|
  Rat    58 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKL 122

  Fly    83 YEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPE 147
            :|||:|:..||||:|...||:::||::.| ..:.|:.||..||||:.|:.||||..:||||||.|
  Rat   123 FEVIETEKTLYLVMEYASGGEVFDYLVAH-GRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAE 186

  Fly   148 NVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYML 212
            |::....:. :|:.||||||:|..|.||:|||||..|:|||:..|..||.|.||:||||||||.|
  Rat   187 NLLLDADMN-IKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTL 250

  Fly   213 VCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIASSAW----- 272
            |.|..||:..|..|....::..||.||.::||||.:|:..:||.:|.||.::|:|....|
  Rat   251 VSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGH 315

  Fly   273 ----LKPIDEPDSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQALDKNKYNHI 333
                |||..||:...:.::.                  |..|:....| ::||..||...||:.:
  Rat   316 EEEELKPYSEPELDLNDAKR------------------IDIMVTMGFA-RDEINDALVSQKYDEV 361

  Fly   334 TATYFLLAELRLRRRRE----------ELAQKQRL---LNDASMKVGDASRKLVPEKPSPTEAQK 385
            .|||.||.    |:..|          .|.|:.|.   ||::::           :.|:..:.|:
  Rat   362 MATYILLG----RKPPEFEGGESLSSGNLCQRSRPSSDLNNSTL-----------QSPAHLKVQR 411

  Fly   386 GGVPISIN-------------VTPAAQFANDGGKPDKRSRKCSIVREEDEE---ESATE--CTAV 432
            .   ||.|             :.||..:.       ||.:..|:..|:.||   ::|..  .|.|
  Rat   412 S---ISANQKQRRFSDHAGPSIPPAVSYT-------KRPQANSVESEQKEEWDKDTARRLGSTTV 466

  Fly   433 GNELKVTSS-----SRREA--------FSDSPFSRS---IHERSSS-----EPGNQTKGEQIANS 476
            |::.:||:|     .|:::        :|....:|.   :.|||:.     :.|..:...:::.|
  Rat   467 GSKSEVTASPLVGPDRKKSSAGPSNNVYSGGSMTRRNTYVCERSTDRYAALQNGRDSSLTEMSAS 531

  Fly   477 GVPSHSRTKIVVSVDATLAHKLKQMEKSAKIDEDTLSGLKELEIGKLKPLPSSSKNPVLTHRRTK 541
            .:.|...|.......|...|: |.|..|....:.||..:|:         .|.:..|..|.:|.
  Rat   532 SMSSTGSTVASAGPSARPRHQ-KSMSTSGHPIKVTLPTIKD---------GSEAYRPGSTAQRV- 585

  Fly   542 LNKIRTPSCSSSEASDDDTK--TRNKKKINKFVGDTPVRFRMHRRDSHDDSSDSQDQLYPPPGSA 604
              ...:||..|..||..|..  .|.....:.|.|: .:|.|.....|...:|.|.|.........
  Rat   586 --PAASPSAHSISASTPDRTRFPRGSSSRSTFHGE-QLRERRSAAYSGPPASPSHDTAALAHARR 647

  Fly   605 SNAGNFISKSGSVSGKK---EGQSQYKEPNNKSDENRKSHSQKNRKQHNKDHVDKHSHAERQLAD 666
            ..:...|||..|...::   ||     |.:.::|..|.|..:...|:..|:      ...|.|..
  Rat   648 GTSTGIISKITSKFVRRDPSEG-----EASGRTDTARGSSGEPKDKEEGKE------AKPRSLRF 701

  Fly   667 SSTATTGNSTNRRRRIRESQSLDRITEAQ--EYEMRHR 702
            :.:..|.:|.:....:||   :.::.:|.  :||.|.|
  Rat   702 TWSMKTTSSMDPNDMVRE---IRKVLDANTCDYEQRER 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	130/263 (49%)
		UBA_SNRK	296..338	CDD:270524	11/41 (27%)
Mark1	XP_038946210.1	STKc_MARK	59..311	CDD:270974	128/253 (51%)
		UBA_MARK1	331..371	CDD:270588	14/62 (23%)
		MARK1-3_C	695..792	CDD:213381	11/45 (24%)