Protein Alignment Snrk and Prkaa1

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: XP_036014946.1
• Gene: Prkaa1 / 105787
• MGIID: 2145955
• Length: 589
• Species: Mus musculus
• Alignment Length: 605
• Identity: 178/605 - (29%)
• Similarity: 265/605 - (43%)
• Gaps: 150/605 - (24%)

  Fly    13 DGKI-AGLYDLEETLGSGHFAVVK------------------------------LARHVFTGAKV 46
            ||:: .|.|.|.:|||.|.|..||                              :.:|..||.||
Mouse    19 DGRVKIGHYILGDTLGVGTFGKVKVPEKGYTDARLLGTLPQQQYLNSYVHIDCLVGKHELTGHKV 83

  Fly    47 AVKVVDKTK---LDDVSKAHLFQEVRCMKLVQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYI 108
            |||::::.|   ||.|.|  :.:|::.:||.:||::::||:||.|.:.:::|:|...||:|:|||
Mouse    84 AVKILNRQKIRSLDVVGK--IRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYI 146

  Fly   109 MKHDSGLSEELARKYFRQILRAITYCHQLHVVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQ 173
            .| :..|.|:.:|:.|:|||..:.|||:..|||||||||||:....:. .|:.|||.||....|:
Mouse   147 CK-NGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGE 209

  Fly   174 KLETFCGSLAYSAPEILLGDSYDAPAVDIWSLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTV 238
            .|.|.|||..|:|||::.|..|..|.|||||.|||||.|:||..||:..:.......|.|..:..
Mouse   210 FLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYT 274

  Fly   239 PSHVSTDCRDLIASMLVRDPKKRATVEEIASSAWLKP------IDEPDSTTSTSEHFLPLVSREQ 297
            |.:::.....|:..||..||.|||.:::|....|.|.      ..|..|.:||      ::..|.
Mouse   275 PQYLNPSVISLLKHMLQVDPMKRAAIKDIREHEWFKQDLPKYLFPEDPSYSST------MIDDEA 333

  Fly   298 LGEEDHAFIIQKMINGNIASKEEILQAL-DKNKYNHITATYFLLAELRLRRRREELAQKQRLLND 361
            |.|....|         ..|:||:|..| ::|..:.:...|.|:.:.|            |::|:
Mouse   334 LKEVCEKF---------ECSEEEVLSCLYNRNHQDPLAVAYHLIIDNR------------RIMNE 377

  Fly   362 ASMKVGDASRKLVP----------EKPSPTEAQKGGVPISINVTPAAQFANDGGKPDK------R 410
            |.    |......|          .:|.|..     ||..:..||.|:...|...|.|      |
Mouse   378 AK----DFYLATSPPDSFLDDHHLTRPHPER-----VPFLVAETPRARHTLDELNPQKSKHQGVR 433

  Fly   411 SRKCSI-VREEDEEES--ATECTAVGN---ELKVTS----SSRREAFSDSPFS------------ 453
            ..|..: :|.:.....  |..|.|:..   |.||.:    ..||:....|.||
Mouse   434 KAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFSKMSLQLYQVDSR 498

  Fly   454 ------RSI-HERSSSEPGNQT--KGEQIAN-------------SGVPSH-SRTKIVVSVDATL- 494
                  ||| .|.:.::.|..|  :...|:|             .|.||. |.|..|.|:|::.
Mouse   499 TYLLDFRSIDDEITEAKSGTATPQRSGSISNYRSCQRSDSDAEAQGKPSDVSLTSSVTSLDSSPV 563

  Fly   495 -------AHKLKQMEKSAKI 507
                   :|.::..|..|.:
Mouse   564 DVAPRPGSHTIEFFEMCANL 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	109/290 (38%)
		UBA_SNRK	296..338	CDD:270524	10/42 (24%)
Prkaa1	XP_036014946.1	STKc_AMPK_alpha	24..309	CDD:270981	109/288 (38%)
		UBA_AID_AAPK1	326..390	CDD:270586	20/94 (21%)
		AMPKA1_C	434..587	CDD:213384	32/150 (21%)