Protein Alignment Snrk and prkaa1

DIOPT Version :10

• Sequence 1: NP_610942.2
• Gene: Snrk / 36579
• FlyBaseID: FBgn0033915
• Length: 860
• Species: Drosophila melanogaster
• Sequence 2: NP_001103756.1
• Gene: prkaa1 / 100001198
• ZFINID: ZDB-GENE-030325-1
• Length: 573
• Species: Danio rerio
• Alignment Length: 683
• Identity: 188/683 - (27%)
• Similarity: 298/683 - (43%)
• Gaps: 166/683 - (24%)

  Fly    13 DGKI-AGLYDLEETLGSGHFAVVKLARHVFTGAKVAVKVVDKTK---LDDVSKAHLFQEVRCMKL 73
            :|:: .|.|.|.:|||.|.|..||:.:|..|..:||||::::.|   ||.|.|  :.:|::.:||
Zfish     9 EGRVKIGHYILGDTLGVGTFGKVKVGQHELTKHQVAVKILNRQKIRSLDVVGK--IRREIQNLKL 71

  Fly    74 VQHPNVVRLYEVIDTQTKLYLVLELGDGGDLYDYIMKHDSGLSEELARKYFRQILRAITYCHQLH 138
            .:||::::||:||.|.|.:::|:|...||:|:|||.|:.. |.|:.:|:.|:||:..:.|||:..
Zfish    72 FRHPHIIKLYQVISTPTDIFMVMEYVSGGELFDYICKNGK-LDEKESRRLFQQIISGVDYCHRHM 135

  Fly   139 VVHRDLKPENVVFFEKLGLVKLTDFGFSNKFLPGQKLETFCGSLAYSAPEILLGDSYDAPAVDIW 203
            |||||||||||:....:. .|:.|||.||....|:.|.|.|||..|:|||::.|..|..|.||||
Zfish   136 VVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIW 199

  Fly   204 SLGVILYMLVCGQAPFEKANDSETLTMIMDCKYTVPSHVSTDCRDLIASMLVRDPKKRATVEEIA 268
            |.|||||.|:||..||:..:.......|.|..:..|.:::.....|:..||..||.||||::||.
Zfish   200 SSGVILYALLCGTLPFDDDHVPTLFKKICDGIFFTPQYLNPSVISLLKHMLQVDPMKRATIKEIR 264

  Fly   269 SSAWLKPIDEP------DSTTSTSEHFLPLVSREQLGEEDHAFIIQKMINGNIASKEEILQAL-D 326
            ...|.|. |.|      |:..|::     ::..|.|.|     :.:|.    ..::||:|..| .
Zfish   265 EDEWFKQ-DLPKYLFPEDAAYSSN-----MIDEEALKE-----VCEKC----ECTEEEVLNCLYS 314

  Fly   327 KNKYNHITATYFLLAELRLRRRREELAQKQRLLNDASMKVGDASRKLVPEKPSPTEAQKGGVPIS 391
            :|..:.:...|.|:.:.|            |::::|.                         ...
Zfish   315 RNHQDPLAVAYHLIIDNR------------RIMSEAK-------------------------DFY 342

  Fly   392 INVTPAAQFANDGGKPDKRSRKCSIVREEDEEESATECTAVGNELKVTSSSRREAFSDSPFSRSI 456
            :..:|...|.:|  .|...|.|....|.               ...|..|..|
Zfish   343 LASSPPDSFLDD--LPAHHSAKVHPERV---------------PFLVAESQPR------------ 378

  Fly   457 HERSSSEPGNQTKGEQIA------NSGVPSHSRTKIVVSVDATLAHKLKQMEKSAKIDEDTLSGL 515
             .|.:.:..|..|.:.:.      :.|:.|.||...::|   .:...:||::...|:
Zfish   379 -PRHTLDELNPQKSKHLGVRRAKWHLGIRSQSRPNDIMS---EVCRAMKQLDYEWKV-------- 431

  Fly   516 KELEIGKLKP--LPSSSKNPVLTHRRTKLNKIRTPSCSSSEASDDDTKTRNKKKINKFVGDTPVR 578
                   :.|  |....|||| |...||:         |.:....|::|        ::.|
Zfish   432 -------VNPYYLRVRRKNPV-TGMHTKM---------SLQLYQVDSRT--------YLLD---- 467

  Fly   579 FRMHRRDSHDDSSDSQDQLYPPPGSASNAGNFISKSGSVSGKKEGQSQYKEPNNKSDENRKSHSQ 643
            ||     |.||     |.:....|:|:.     .:||||     |..:....|:||::|....:.
Zfish   468 FR-----SIDD-----DMMEVKSGTATP-----HRSGSV-----GNYRTTLKNDKSEKNECEDAA 512

  Fly   644 KNR-KQHNKDHVDKHSHAERQLADSSTATTGNS 675
            |.. ...:...:.....||..||.|.|::..::
Zfish   513 KGEASAPSTPPISASKVAEGSLASSLTSSVDST 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snrk	NP_610942.2	STKc_SNRK	16..273	CDD:270976	109/260 (42%)
		UBA_SNRK	296..338	CDD:270524	9/42 (21%)
prkaa1	NP_001103756.1	STKc_AMPK_alpha	14..269	CDD:270981	109/258 (42%)
		UBA_AID_AAPK1	286..350	CDD:270586	15/114 (13%)
		AMPKA1_C	398..571	CDD:213384	45/208 (22%)