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Protein Alignment Opa1 and MFN2

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001121132.1	Gene:	MFN2 / 9927	HGNCID:	16877	Length:	757	Species:	Homo sapiens

Alignment Length:	834	Identity:	171/834 - (20%)
Similarity:	309/834 - (37%)	Gaps:	244/834 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 LKTNKK-------------TTAKK------------IKKS---LIDMY-----------SEVLDE 285
            :|.||:             .||||            |::|   |.|.|           .:|||
Human    14 VKKNKRHMAEVNASPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEEQVLD- 77

  Fly   286 LSGY-----DTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAEG 345
            :.||     .....:|....:|...|..|:||::|:.::...::.|.|.|. .|...::|   ||
Human    78 VKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGH-TTNCFLRV---EG 138

  Fly   346 PYHVAQFRDSDREYDLTKESDLQDLRRDVE-----FRMKASVRGGKTVSNEVIAMTVKGPGLQ-R 404
                   .|....:.||:.|:.:...:.|.     ......:..|..||  |:....|.|.|: .
Human   139 -------TDGHEAFLLTEGSEEKRSAKTVNQLAHALHQDKQLHAGSLVS--VMWPNSKCPLLKDD 194

  Fly   405 MVLVDLPGIISTMTVD--------------MASDTKDSIHQMTKHY-------MSNPNAIILCIQ 448
            :||:|.|||..|..:|              :.::::.::.|..||:       :|.||..||..:
Human   195 LVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKHFFHKVSERLSRPNIFILNNR 259

  Fly   449 DGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRI-----RKILSGKLFPMKALGY 508
            ..:..:|...:.::..|  .:.|.|.|::.::.:.:.....|||     :::|:.::  .||.|
Human   260 WDASASEPEYMEEVRRQ--HMERCTSFLVDELGVVDRSQAGDRIFFVSAKEVLNARI--QKAQG- 319

  Fly   509 YAVVTGRGRKDDSIDAIRQYEEDFFKNSKLFHRR-----------GVIMPHQVTSRNLSLAVSDR 562
              :..|.|...:... :|.:|   |:|   |.||           .....|.|.::.::.||
Human   320 --MPEGGGALAEGFQ-VRMFE---FQN---FERRFEECISQSAVKTKFEQHTVRAKQIAEAV--- 372

  Fly   563 FWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDEL-FDKAKGEIL--DEVVTLSQISA 624
              :::.:::...|           .|.:.....:||..:|.| |...:.|:|  |..:.:.||:
Human   373 --RLIMDSLHMAA-----------REQQVYCEEMREERQDRLKFIDKQLELLAQDYKLRIKQIT- 423

  Fly   625 KKWDDALSTKLWEKL-------SNYVFESIYLPAAQSGSQNSFNTMVDIKL-RQWAEQALPAKSV 681
            ::.:..:||.:.|::       .:|..:....|......:|..:..::..| |..:::.  :.::
Human   424 EEVERQVSTAMAEEIRRLSVLVDDYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSDRC--STAI 486

  Fly   682 EAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQLNTLE--- 743
            ....:.:||:.|            ||:...|..:|..:           ||||...|..:|.
Human   487 TNSLQTMQQDMI------------DGLKPLLPVSVRSQ-----------IDMLVPRQCFSLNYDL 528

  Fly   744 --DRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNE 806
              |:...|.||   .::|..|.....||.      :..||...||    ..:..:.|.:|.:.
Human   529 NCDKLCADFQE---DIEFHFSLGWTMLVN------RFLGPKNSRR----ALMGYNDQVQRPIP-- 578

  Fly   807 LDKILKNDTKHLP-----TLTHDE-----LTTVRKNLQRDNVDVDT------------------- 842
                |......:|     :||.:|     :|.:.....|.::.:..
Human   579 ----LTPANPSMPPLPQGSLTQEEFMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFG 639

  Fly   843 ------DYIRQTWFPVYRKH-FLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIK 900
                  .|.|.||....::. |.:|.::.|.:..:....||  |:.|.         .::||.:.
Human   640 LYGLLYVYERLTWTTKAKERAFKRQFVEHASEKLQLVISYT--GSNCS---------HQVQQELS 693

  Fly   901 ITGNALRQQV-INREARRLDKEIKAVLD--EFSDDEEKKGYLLTGKRVLLAEEL 951
            .|...|.||| :.||  .|::||.|:..  |..|..:.|..||..|...|..||
Human   694 GTFAHLCQQVDVTRE--NLEQEIAAMNKKIEVLDSLQSKAKLLRNKAGWLDSEL 745

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.