DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and VPS1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_012926.1	Gene:	VPS1 / 853870	SGDID:	S000001709	Length:	704	Species:	Saccharomyces cerevisiae

Alignment Length:	715	Identity:	161/715 - (22%)
Similarity:	283/715 - (39%)	Gaps:	149/715 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   275 LIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPV- 338
            ||...:::.|.|:....|......||::.|||.|||||:||||:|......|||:| ::||.|:
Yeast     5 LISTINKLQDALAPLGGGSQSPIDLPQITVVGSQSSGKSSVLENIVGRDFLPRGTG-IVTRRPLV 68

  Fly   339 --------------KVTLAEGPYHVAQFRDSDREYDLT------------KES------------ 365
                          ||.............|.|::.|.:            ||.
Yeast    69 LQLINRRPKKSEHAKVNQTANELIDLNINDDDKKKDESGKHQNEGQSEDNKEEWGEFLHLPGKKF 133

  Fly   366 -DLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSI 429
             :..::|:::.............:|:..|.:.:..|.:..:.||||||:......|...|.:..|
Yeast   134 YNFDEIRKEIVKETDKVTGANSGISSVPINLRIYSPHVLTLTLVDLPGLTKVPVGDQPPDIERQI 198

  Fly   430 HQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRK 494
            ..|...|:|.||||||.:...:.|...|:...|..:.||.|.|||.|||||||.::..|   :..
Yeast   199 KDMLLKYISKPNAIILSVNAANTDLANSDGLKLAREVDPEGTRTIGVLTKVDLMDQGTD---VID 260

  Fly   495 ILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQYEEDFFKNSKLFHRRGVIMPHQVTSRNL 555
            ||:|::.|:: .||..|: .||:||    .:|....:.|..||:|...:..:.    |...:..|
Yeast   261 ILAGRVIPLR-YGYIPVI-NRGQKDIEHKKTIREALENERKFFENHPSYSSKA----HYCGTPYL 319

  Fly   556 SLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFDKAKGEILDEVVTLS 620
            :..::......:|:|:.:.....:||....:.|..|..|        |..|.|...:|..:...|
Yeast   320 AKKLNSILLHHIRQTLPEIKAKIEATLKKYQNELINLGP--------ETMDSASSVVLSMITDFS 376

  Fly   621 QISAKKWDDALSTKLWEKLS-----NYVFESIYL-------PAAQ-------------SGSQNS- 659
            ...|...|........::||     :|||...:.       |..|             |||..|
Yeast   377 NEYAGILDGEAKELSSQELSGGARISYVFHETFKNGVDSLDPFDQIKDSDIRTIMYNSSGSAPSL 441

  Fly   660 ------FNTMVDIKLRQWAEQALPAKSVEAGWEAL---QQEFISLMERSKKAQDHDGIFDQ---- 711
                  |..:|..::|::.|.:|  :.|...::.|   .::.||..:.|:.....:.|.:|
Yeast   442 FVGTEAFEVLVKQQIRRFEEPSL--RLVTLVFDELVRMLKQIISQPKYSRYPALREAISNQFIQF 504

  Fly   712 LKSA-------VVDEAIRRHSWEDKA-IDMLRVIQLNTLEDRFVHDKQ-----EWDSAVKFLESS 763
            ||.|       |||......::.:.| .|:|:..|...:.:..:|.:|     :....:....||
Yeast   505 LKDATIPTNEFVVDIIKAEQTYINTAHPDLLKGSQAMVMVEEKLHPRQVAVDPKTGKPLPTQPSS 569

  Fly   764 VNAKLVQ-------------TEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNELDKILKNDT 815
            ..|.:::             .::.||.:..|..:.:      .|....:|.:::.|:.|:|.:..
Yeast   570 SKAPVMEEKSGFFGGFFSTKNKKKLAALESPPPVLK------ATGQMTERETMETEVIKLLISSY 628

  Fly   816 KHLPTLTHDEL---TTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQ-------ALQRAKDCRK 870
            ..:...|..::   ..:.|.:.:...|:....:.:    :|.|..:::       .:||.|:|:|
Yeast   629 FSIVKRTIADIIPKALMLKLIVKSKTDIQKVLLEK----LYGKQDIEELTKENDITIQRRKECKK 689

Fly 871 870
Yeast 690 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	88/317 (28%)
VPS1	NP_012926.1	DLP_1	27..336	CDD:206738	88/318 (28%)
		Dynamin_M	258..541	CDD:395818	65/298 (22%)
		GED	616..704	CDD:396682	13/78 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910