Protein Alignment Opa1 and FZO1

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_009738.1
• Gene: FZO1 / 852477
• SGDID: S000000383
• Length: 855
• Species: Saccharomyces cerevisiae
• Alignment Length: 931
• Identity: 173/931 - (18%)
• Similarity: 326/931 - (35%)
• Gaps: 283/931 - (30%)

  Fly   156 PKLK------QLGEDKLSEWRNWFDSRLDDAIEAADYQGVQIVETK---DDLKAKTTVAALGITS 211
            |.|:      .|...:||:| |:.::|:  .::.:      |::|:   |.|:.:..:..:.|.:
Yeast    71 PSLRSSNSKAHLISSQLSQW-NYNNNRV--LLKRS------ILKTQAFMDQLQEENNIRPIFIAA 126

  Fly   212 DESRKKYE------KLQSQVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLILKTNKKTTAKK 270
            ::.|:|..      ||..|..|.:....|::   :|.|.|       |....::..||.....||
Yeast   127 NDEREKLHVLQLNIKLDGQYNTKEKNGFNIE---KKALSK-------LFHSQIVSVTNHLNALKK 181

  Fly   271 IKKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFP--------- 326
                       .:|::|.            :|.:.||.::||:::..|:.|.|:.|
Yeast   182 -----------RVDDVSS------------KVFITGDVNTGKSALCNSLLKQRLLPEDQLPCTNV 223

  Fly   327 --------RGSG-EMMTRAPVKV--TLAEG--PYHVAQFRDSDREYDLTKESDLQDLRRDVEFRM 378
                    ...| |.:...|:.:  ||.|.  .|.:    .:.:.|::....:|.||
Yeast   224 FSEILEARENDGIEEVHAIPLNIAPTLKEAIDMYSI----QNPKTYEIHTLKELPDL-------- 276

  Fly   379 KASVRGGKTVSNEVIAMTVKGP--------GLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKH 435
              ..:.||....::.....|.|        |...:.|:|.||:           ..||:  .|..
Yeast   277 --VPQNGKYALLKIYIKDDKRPASTSLLRNGTVDISLIDSPGL-----------NMDSL--QTAE 326

  Fly   436 YMSNPNAIILCIQDGSVDAERS---NVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILS 497
            .||....|.|.|  ..|:||..   :..:.:.......:...||:.|.|   ::.|..|.::::
Yeast   327 VMSRQEEIDLVI--FVVNAENQLTLSAKEFISLASREKKLMFFVVKKFD---KIRDKQRCKELI- 385

  Fly   498 GKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEEDFFKNSKLF----HRRGVIMPHQVTSRNLSLA 558
                                    :..||....:.:|.:..|    .:.|..:|| ..:.|.:..
Yeast   386 ------------------------LKQIRDLSPETYKRAADFVHFVSKNGDELPH-YHNENDNED 425

  Fly   559 VSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFDK--------AK---GEI 612
            ..||         :...|.:.:      ::...:|..|.:|.|:.:..|        ||   .::
Yeast   426 HGDR---------KPDDDPYSS------SDPDPDFDSLEDSLRNFVLKKRSLSKLLPAKTYLSKL 475

  Fly   613 LDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALP 677
            |.:::.:|:.:.|.:.:. ..|:.|:|.....|.:    :.....|...|.||    |.|||.:.
Yeast   476 LSDIIMISKSNMKMYSEE-EIKINEQLETLRPEIL----SARAKCNDLTTSVD----QMAEQTIT 531

  Fly   678 A---KSVEAGWEALQQEFISLMERSK---KAQDHDGIF-------DQLKSAVVDEAIRRHSWEDK 729
            .   .:.||...||.   :.|.|..|   ..|.:|.||       :|:..::....:......|.
Yeast   532 MTYNNTKEALLNALD---VPLHEYPKYQGLGQIYDFIFSTEAFIANQIDESIGSSELFAKQKTDL 593

  Fly   730 AIDMLRVIQLNTLEDRFVHDKQEWDSAVKFLE-SSVNAKLVQTEETLAQMFGPGQMRRITH--WQ 791
            .:..:..|..|.|.|.|:.:: .:.|.:.|.: ..:..|.::...::..:|.|.....:::  ||
Yeast   594 LVKKIYEIGKNELGDDFMCER-VFRSELMFRKRKHLIGKRLKVSLSITDLFAPTWKGFLSYLSWQ 657

  Fly   792 Y-LTQDQQKRRSVKNE----LDKI--LKN-------------DTKHLPTLTHDEL--TTVRKNLQ 834
            . :|..........||    |.|.  |||             .|..:||||...|  |.|..|:.
Yeast   658 KPVTAPLPDIEGQTNEGQIGLMKYLGLKNYPLTQYWSRPSLLFTSKIPTLTLYFLGSTKVVGNII 722

  Fly   835 RDNVDVDT-DYIRQTWFPV----------YRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSD 888
            .:.:.:.: ..:::...||          |..|.|.:||.
Yeast   723 LNGIKLSSWSSLKKLSVPVIVVGSLLGLTYLIHDLPRALP------------------------- 762

  Fly   889 VVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDEFSDDEEKKGYLLTGKRVLLAEELIK 953
                  :...||..........|:..|:|...|::.||...:.:      :|....:::.::.|.
Yeast   763 ------MNLSIKYKRKLQELDYIHLNAQRTSNEVRDVLRVPTRE------ILRSCEIIMDKKQIT 815

  Fly   954 VRQIQEKLE------EFINSL 968
            .::::.|.|      :|..||
Yeast   816 KKELENKKESNLLSIKFFQSL 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	56/310 (18%)
		OPA1_C	629..972	CDD:466080	76/395 (19%)
FZO1	NP_009738.1	P-loop containing Nucleoside Triphosphate Hydrolases	189..456	CDD:476819	61/339 (18%)