Protein Alignment Opa1 and DNM1

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_013100.1
• Gene: DNM1 / 850686
• SGDID: S000003924
• Length: 757
• Species: Saccharomyces cerevisiae
• Alignment Length: 826
• Identity: 182/826 - (22%)
• Similarity: 326/826 - (39%)
• Gaps: 209/826 - (25%)

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||...:::.|.:  ||:|....| ||.:.|||.|||||:|:||::......|||:| ::||.|
Yeast     5 EDLIPTVNKLQDVM--YDSGIDTLD-LPILAVVGSQSSGKSSILETLVGRDFLPRGTG-IVTRRP 65

  Fly   338 V----------------------------KVTLAEGPYHVAQFRDSDREY-DLTKE--------- 364
            :                            |::..|......::|..:|.: |...|
Yeast    66 LVLQLNNISPNSPLIEEDDNSVNPHDEVTKISGFEAGTKPLEYRGKERNHADEWGEFLHIPGKRF 130

  Fly   365 SDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSI 429
            .|..|::|::|..........|.:|...|.:.|..|.:..:.|||||||......:...|.:..|
Yeast   131 YDFDDIKREIENETARIAGKDKGISKIPINLKVFSPHVLNLTLVDLPGITKVPIGEQPPDIEKQI 195

  Fly   430 HQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRK 494
            ..:...|::.||.:||.:...:||...|....|..:.||.|:|||.|:||:||.:   .......
Yeast   196 KNLILDYIATPNCLILAVSPANVDLVNSESLKLAREVDPQGKRTIGVITKLDLMD---SGTNALD 257

  Fly   495 ILSGKLFPMKALGYYAVVTGRGRKD--------DSIDAIRQYEEDFFKNSKLFHRRGVIMPHQVT 551
            |||||::|:| ||:..|| .|.::|        :|:|.    |||:|:...::
Yeast   258 ILSGKMYPLK-LGFVGVV-NRSQQDIQLNKTVEESLDK----EEDYFRKHPVY------------ 304

  Fly   552 SRNLSLAVSDRFW-KMVRET----IEQQADAFKATRFNL---ETEWKNNFPRLRESGRDELFDKA 608
             |.:|.....|:. |::.:|    |..:....| |:.|.   :||.:    ..|..|.....:::
Yeast   305 -RTISTKCGTRYLAKLLNQTLLSHIRDKLPDIK-TKLNTLISQTEQE----LARYGGVGATTNES 363

  Fly   609 KGEILDEVVT------LSQISAKKWDDALSTKLWEKLSN-----YVFESIYLPAAQSGSQNSFNT 662
            :..::.:::.      :|.|.....|  ::||   :|..     |::.:::..:.:|....|..:
Yeast   364 RASLVLQLMNKFSTNFISSIDGTSSD--INTK---ELCGGARIYYIYNNVFGNSLKSIDPTSNLS 423

  Fly   663 MVDIK--LRQWAEQALPAKSV-EAGWEALQQEFIS-LMERSKKAQD----------HD------G 707
            ::|::  :|. :....|...| |..::.|.:..|. |:|.|::..:          |.      .
Yeast   424 VLDVRTAIRN-STGPRPTLFVPELAFDLLVKPQIKLLLEPSQRCVELVYEELMKICHKCGSAELA 487

  Fly   708 IFDQLKS---AVVDEAIRR-----HSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFL---- 760
            .:.:|||   .|:.|.:|.     .|:.:..||:.|. .:||....|:...:..|..:|..
Yeast   488 RYPKLKSMLIEVISELLRERLQPTRSYVESLIDIHRA-YINTNHPNFLSATEAMDDIMKTRRKRN 551

  Fly   761 ESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLT----QDQQKRRSV---------KNELDKILK 812
            :..:.:||.|.|.        ||...|.....::    ||..|....         |...||.|.
Yeast   552 QELLKSKLSQQEN--------GQTNGINGTSSISSNIDQDSAKNSDYDDDGIDAESKQTKDKFLN 608

  Fly   813 ----NDTKHLPTL-THDELTTVR--------KNLQRDNVDV-DTDYIRQTWFPVYRKHFLQQALQ 863
                .|.|..|.. ..|:..::.        :|||..:..: |.|.:.....|:..:..|
Yeast   609 YFFGKDKKGQPVFDASDKKRSIAGDGNIEDFRNLQISDFSLGDIDDLENAEPPLTEREEL----- 668

  Fly   864 RAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDE 928
                             |||:          |:::|....:.:|:.:.:    ::.|.:..:|..
Yeast   669 -----------------ECEL----------IKRLIVSYFDIIREMIED----QVPKAVMCLLVN 702

  Fly   929 FSDDEEKKGYLLTG--KRVLLAEELIKVRQIQEKLEEFINSLNQEK 972
            :..| ..:..|:|.  |..|..|.|::.:.:.:..|..:.||...|
Yeast   703 YCKD-SVQNRLVTKLYKETLFEELLVEDQTLAQDRELCVKSLGVYK 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	88/324 (27%)
		OPA1_C	629..972	CDD:466080	75/408 (18%)
DNM1	NP_013100.1	DLP_1	26..333	CDD:206738	90/330 (27%)
		Dynamin_M	254..540	CDD:460033	65/316 (21%)
		GED	665..756	CDD:128597	20/120 (17%)