DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and DNM1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_013100.1	Gene:	DNM1 / 850686	SGDID:	S000003924	Length:	757	Species:	Saccharomyces cerevisiae

Alignment Length:	826	Identity:	182/826 - (22%)
Similarity:	326/826 - (39%)	Gaps:	209/826 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||...:::.|.:  ||:|....| ||.:.|||.|||||:|:||::......|||:| ::||.|
Yeast     5 EDLIPTVNKLQDVM--YDSGIDTLD-LPILAVVGSQSSGKSSILETLVGRDFLPRGTG-IVTRRP 65

  Fly   338 V----------------------------KVTLAEGPYHVAQFRDSDREY-DLTKE--------- 364
            :                            |::..|......::|..:|.: |...|
Yeast    66 LVLQLNNISPNSPLIEEDDNSVNPHDEVTKISGFEAGTKPLEYRGKERNHADEWGEFLHIPGKRF 130

  Fly   365 SDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSI 429
            .|..|::|::|..........|.:|...|.:.|..|.:..:.|||||||......:...|.:..|
Yeast   131 YDFDDIKREIENETARIAGKDKGISKIPINLKVFSPHVLNLTLVDLPGITKVPIGEQPPDIEKQI 195

  Fly   430 HQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRK 494
            ..:...|::.||.:||.:...:||...|....|..:.||.|:|||.|:||:||.:   .......
Yeast   196 KNLILDYIATPNCLILAVSPANVDLVNSESLKLAREVDPQGKRTIGVITKLDLMD---SGTNALD 257

  Fly   495 ILSGKLFPMKALGYYAVVTGRGRKD--------DSIDAIRQYEEDFFKNSKLFHRRGVIMPHQVT 551
            |||||::|:| ||:..|| .|.::|        :|:|.    |||:|:...::
Yeast   258 ILSGKMYPLK-LGFVGVV-NRSQQDIQLNKTVEESLDK----EEDYFRKHPVY------------ 304

  Fly   552 SRNLSLAVSDRFW-KMVRET----IEQQADAFKATRFNL---ETEWKNNFPRLRESGRDELFDKA 608
             |.:|.....|:. |::.:|    |..:....| |:.|.   :||.:    ..|..|.....:::
Yeast   305 -RTISTKCGTRYLAKLLNQTLLSHIRDKLPDIK-TKLNTLISQTEQE----LARYGGVGATTNES 363

  Fly   609 KGEILDEVVT------LSQISAKKWDDALSTKLWEKLSN-----YVFESIYLPAAQSGSQNSFNT 662
            :..::.:::.      :|.|.....|  ::||   :|..     |::.:::..:.:|....|..:
Yeast   364 RASLVLQLMNKFSTNFISSIDGTSSD--INTK---ELCGGARIYYIYNNVFGNSLKSIDPTSNLS 423

  Fly   663 MVDIK--LRQWAEQALPAKSV-EAGWEALQQEFIS-LMERSKKAQD----------HD------G 707
            ::|::  :|. :....|...| |..::.|.:..|. |:|.|::..:          |.      .
Yeast   424 VLDVRTAIRN-STGPRPTLFVPELAFDLLVKPQIKLLLEPSQRCVELVYEELMKICHKCGSAELA 487

  Fly   708 IFDQLKS---AVVDEAIRR-----HSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFL---- 760
            .:.:|||   .|:.|.:|.     .|:.:..||:.|. .:||....|:...:..|..:|..
Yeast   488 RYPKLKSMLIEVISELLRERLQPTRSYVESLIDIHRA-YINTNHPNFLSATEAMDDIMKTRRKRN 551

  Fly   761 ESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLT----QDQQKRRSV---------KNELDKILK 812
            :..:.:||.|.|.        ||...|.....::    ||..|....         |...||.|.
Yeast   552 QELLKSKLSQQEN--------GQTNGINGTSSISSNIDQDSAKNSDYDDDGIDAESKQTKDKFLN 608

  Fly   813 ----NDTKHLPTL-THDELTTVR--------KNLQRDNVDV-DTDYIRQTWFPVYRKHFLQQALQ 863
                .|.|..|.. ..|:..::.        :|||..:..: |.|.:.....|:..:..|
Yeast   609 YFFGKDKKGQPVFDASDKKRSIAGDGNIEDFRNLQISDFSLGDIDDLENAEPPLTEREEL----- 668

  Fly   864 RAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDE 928
                             |||:          |:::|....:.:|:.:.:    ::.|.:..:|..
Yeast   669 -----------------ECEL----------IKRLIVSYFDIIREMIED----QVPKAVMCLLVN 702

  Fly   929 FSDDEEKKGYLLTG--KRVLLAEELIKVRQIQEKLEEFINSLNQEK 972
            :..| ..:..|:|.  |..|..|.|::.:.:.:..|..:.||...|
Yeast   703 YCKD-SVQNRLVTKLYKETLFEELLVEDQTLAQDRELCVKSLGVYK 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	88/324 (27%)
DNM1	NP_013100.1	DLP_1	26..333	CDD:206738	90/330 (27%)
		Dynamin_M	255..540	CDD:395818	65/315 (21%)
		GED	665..756	CDD:128597	20/120 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910