DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and DRP4C

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_176252.1	Gene:	DRP4C / 842345	AraportID:	AT1G60500	Length:	669	Species:	Arabidopsis thaliana

Alignment Length:	786	Identity:	179/786 - (22%)
Similarity:	292/786 - (37%)	Gaps:	224/786 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 KKTTAKK----IKKSLIDMYSE----VLDELSGYDTGYTMAD--HLPRVVVVGDQSSGKTSVLES 318
            ||:.:.|    ::..:|..|::    :||.:........|.:  |||.:||||||||||:|||||
plant    20 KKSRSNKDVVSVEAPIISSYNDRIRPLLDTVDRLRNLNVMREGIHLPTIVVVGDQSSGKSSVLES 84

  Fly   319 IAKARIFPRGSGEMMTRAPVKVTLAEGPYHVAQFRDSDREYDLTKE-------SDLQDLRRDVEF 376
            :|...: |||.| :.||.|:.:.|.         |.|..|.::..|       :|.:.:...:..
plant    85 LAGISL-PRGQG-ICTRVPLVMRLQ---------RSSSPEPEIWLEYNDKVVPTDEEHIAEAIRA 138

  Fly   377 RMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPN 441
            ........||.||:..:.:.||..|:..:.:||||||..........:..:.|..|...|:....
plant   139 ATDVIAGSGKGVSDAPLTLHVKKAGVPDLTMVDLPGITRVPVNGQPENIYEQISGMIMEYIEPQE 203

  Fly   442 AIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKAL 506
            :|||.:...:||........:..:.|..|:||:.|:||.|:|.|    ..::|:.:..:  ...|
plant   204 SIILNVLSATVDFTTCESIRMSRKVDKTGQRTLAVVTKADMAPE----GLLQKVTADDV--SIVL 262

  Fly   507 GYYAVVTGRGRKDDSIDAIRQYEEDFFKNSKLFHRRGV-------IMPHQVTSRNLSLAVSD--- 561
            ||..|....|.:        .|||...:...||....|       |:...|.::.|.|..|.
plant   263 GYVCVRNRIGEE--------TYEEARMQEELLFRTHPVLSLIDEDIVGIPVLAQKLMLIQSSMIA 319

  Fly   562 RFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFDKAKGEILDEVVTLSQISAKK 626
            |....:...|.|:.|...     ||.   |..|.:..|         .||.|   :.|..|....
plant   320 RCLPKIVSKINQKLDTAV-----LEL---NKLPMVMAS---------TGEAL---MALMDIIGSA 364

  Fly   627 WDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNT--MVDIKLRQWAEQALPAKSVEAGWEALQ 689
            .:..|...:....|.|           ...||...|  :.|: |.|::: :|.||..|..
plant   365 KESLLRILVQGDFSEY-----------PDDQNMHCTARLADM-LSQFSD-SLQAKPKEVA----- 411

  Fly   690 QEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRHSW-----------EDKAIDMLRVIQLNTLE 743
             ||  ||:..|       |.|:.|...:...|.|.::           :||.::.:..|
plant   412 -EF--LMDEIK-------ILDECKCVGLPNFIPRSAFLAILSQHVDGIQDKPVEFINKI------ 460

  Fly   744 DRFVHDKQEWDSAVKFLE---SSVNAK------LVQT--------------EETLAQMFGPGQMR 785
                     ||    ::|   |||.||      .:|:              |:::.::....:|.
plant   461 ---------WD----YIEDVLSSVTAKRSDNFPQIQSSIKRAGRNLISKIKEQSVNRVMEIVEME 512

  Fly   786 RITHW----QYLTQDQQKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIR 846
            ::|.:    :|:|...||..:.::.:|.::||:  ::|                       ||..
plant   513 KLTDYTCNPEYMTSWTQKTSAQESFIDAVVKNE--NIP-----------------------DYFS 552

  Fly   847 QTWF--------PVYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRI--QQVIKI 901
            .|.|        ..|..|.|..|.    |.:..                 :..:|:|  ::::..
plant   553 VTGFGNVKISHLRKYHAHLLIPAF----DMKMR-----------------ITSYWKIVLRRIVDN 596

  Fly   902 TGNALRQQVINREARRLDKEIKAVLDEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFIN 966
            ....|:..|.:....|..|||.|   |..|..:..|.    :::|  ||...|...:|||:..|.
plant   597 LALYLQLSVKSLVNTRFQKEIVA---EMVDPRDGGGV----EKML--EESPLVASKREKLQNSIK 652

  Fly   967 SLNQEK 972
            .|.:.|
plant   653 LLKESK 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	81/290 (28%)
DRP4C	NP_176252.1	DLP_1	63..323	CDD:206738	81/284 (29%)
		Dynamin_M	256..529	CDD:279383	70/349 (20%)
		GED	567..664	CDD:128597	27/122 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910