DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and DL3

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_176170.1	Gene:	DL3 / 842251	AraportID:	AT1G59610	Length:	920	Species:	Arabidopsis thaliana

Alignment Length:	834	Identity:	163/834 - (19%)
Similarity:	293/834 - (35%)	Gaps:	276/834 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 IDMYSEVLDE-------LSGYDTGYTMADHLP----RVVVVGDQSSGKTSVLESIAKARIFPRGS 329
            ||..|::.|.       |:..|...|.:...|    .||.:|:..:||::||.|:....:.|.|.
plant     4 IDELSQLSDSMRQAASLLADEDPDETSSSRRPATSLNVVALGNVGAGKSAVLNSLIGHPVLPTGE 68

  Fly   330 GEMMTRAPVKVTLAEGPYHVAQFRDSDREYDLTKES------------DLQDLRRDVEFRMK--A 380
            .. .||||:.:             |..||..|:.::            ....||..::.|:.  |
plant    69 NG-ATRAPIII-------------DLSREESLSSKAIILQIDNKNQQVSASALRHSLQDRLSKGA 119

  Fly   381 SVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIIL 445
            |.||...:..::  .|...|.|:   |:||||:...:..|          .|...:..:.:||:|
plant   120 SGRGRDEIYLKL--RTSTAPPLK---LIDLPGLDQRIVDD----------SMIGEHAQHNDAILL 169

  Fly   446 CIQDGSVDAE--RSNVTDLVMQCDPLGRRTIFVLTKVDLAEE----LADPDRIRKILSGKLFPMK 504
            .:...|..:|  .|....:..:.||...||:.:::|:|.|.|    ||   .::.:||.:..|..
plant   170 VVVPASQASEISSSRALKIAKEYDPESTRTVGIISKIDQAAENPKSLA---AVQALLSNQGPPKT 231

  Fly   505 ALGYYAVVTGR---------GRKDDSIDAIRQYEEDFFKN--------------------SKLFH 540
            ....:..:.|:         |..::|::...:.|.:..|:                    |::..
plant   232 TDIPWVALIGQSVSIASAQSGGSENSLETAWRAESESLKSILTGAPQSKLGRIALVDTLASQIRS 296

  Fly   541 RRGVIMPHQVTS-RNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETE---------------- 588
            |..:.:|:.:|. :..|..|.|...:: .|.:...|:..:|....|..|
plant   297 RMKLRLPNILTGLQGKSQIVQDELARL-GEQLVSSAEGTRAIALELCREFEDKFLLHLAGGEGSG 360

  Fly   589 WK------NNFP-RLRESGRDELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFES 646
            ||      .||| |:::...|..||      |:.|                       ...|.|:
plant   361 WKVVASFEGNFPNRIKKLPLDRHFD------LNNV-----------------------KRIVLEA 396

  Fly   647 ----IYLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDG 707
                .||.:.:.|.::...|::::     |:.  ||:...   :.:.:..:.::..|..|....|
plant   397 DGYQPYLISPEKGLRSLIKTVLEL-----AKD--PARLCV---DEVHRVLVDIVSASANATPGLG 451

  Fly   708 IFDQLKSAVVDEAIRRHSWEDKAIDMLR------VIQLNTLEDRFVHDKQEWDSAVKFLESSVNA 766
            .:...|..||..|       ..|:|..:      |:.|..:|..||..:.       |:
plant   452 RYPPFKREVVAIA-------SAALDGFKNEAKKMVVALVDMERAFVPPQH-------FI------ 496

  Fly   767 KLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNELD---KILKNDTKHL---PTLTHDE 825
            :|||              ||:...:  .:::.|.||.|...|   .:|...|...   |:.|...
plant   497 RLVQ--------------RRMERQR--REEELKGRSSKKGQDAEQSLLNRATSPQPDGPSSTGGS 545

  Fly   826 LTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVV 890
            |.::|..|...:.|.|                      :.|:..:...|.| .|.|.||:..
plant   546 LKSLRDKLMPQDKDKD----------------------KEKETPEVSGLKT-AGPEGEITAG--- 584

  Fly   891 LFWRIQQVIKITGNALRQQVINREARRL-------DKEIKAV-------LDEFSDDEEKKG---- 937
              :.:::..|..|.:.|..|:|.:..:|       ::..:..       ::|.||||.:|.
plant   585 --YLMKKSAKTNGWSRRWFVLNEKTGKLGYTKKQEERNFRGTVTLEECSIEEISDDEGEKSKSSK 647

  Fly   938 ---------------YLLT----GKRVLLAEE--LIKVRQIQEKLEEFINSLNQ 970
                           :.:|    .|.||.|..  ::|...:.:| .|:||.|.:
plant   648 DKKSNGPDSKGPGLVFKITCRVPYKTVLKAHNALVLKAESMVDK-NEWINKLQK 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	68/327 (21%)
DL3	NP_176170.1	DLP_1	41..303	CDD:206738	61/293 (21%)
		Dynamin_M	<371..490	CDD:366427	29/164 (18%)
		PH	584..703	CDD:214574	23/123 (19%)
		GED	744..817	CDD:383023
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910