DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and DRP3A

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001190906.1	Gene:	DRP3A / 829506	AraportID:	AT4G33650	Length:	809	Species:	Arabidopsis thaliana

Alignment Length:	813	Identity:	183/813 - (22%)
Similarity:	326/813 - (40%)	Gaps:	187/813 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 TNKKTTAKKIKKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFP 326
            ::..|.|..:..|:|.:.:::.|..:...:..|:|  ||:|||||.|||||:||||::......|
plant    24 SSSTTNAAPLGSSVIPIVNKLQDIFAQLGSQSTIA--LPQVVVVGSQSSGKSSVLEALVGRDFLP 86

  Fly   327 RGSGEMMTRAPVKVTLAEGPYHVAQFRDSD----REYDLTKESDLQDLRRDVEFRMKASVRGGKT 387
            ||: ::.||.|:.:.|.:.........|.:    |....|:..|..::||::|......|...|.
plant    87 RGN-DICTRRPLVLQLLQTKSRANGGSDDEWGEFRHLPETRFYDFSEIRREIEAETNRLVGENKG 150

  Fly   388 VSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSV 452
            |::..|.:.:..|.:..:.|||||||......|..||.:..|..|...|:.....:||.:...:.
plant   151 VADTQIRLKISSPNVLNITLVDLPGITKVPVGDQPSDIEARIRTMILSYIKQDTCLILAVTPANT 215

  Fly   453 DAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGR 517
            |...|:...:....||.|.|||.|:||:|:.::..|   .||:|.|.:.|:: |||..|| .|.:
plant   216 DLANSDALQIASIVDPDGHRTIGVITKLDIMDKGTD---ARKLLLGNVVPLR-LGYVGVV-NRCQ 275

  Fly   518 KDDSID-AIRQ---YEEDFFKNSKLFH----RRGVIMP------HQVTSRNLSLAVSDRFWKMVR 568
            :|..:: .:::   .||.||::..::|    |.||  |      :|:..:::.:.:.|     ::
plant   276 EDILLNRTVKEALLAEEKFFRSHPVYHGLADRLGV--PQLAKKLNQILVQHIKVLLPD-----LK 333

  Fly   569 ETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFDKAKGEILDEVVTLSQISAKKWDDALST 633
            ..|   ::|..||     .:...::..|.||      ...:|.:|     |:.:|  |:.:|.|:
plant   334 SRI---SNALVAT-----AKEHQSYGELTES------RAGQGALL-----LNFLS--KYCEAYSS 377

  Fly   634 KL---WEKLS----------NYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSV---- 681
            .|   .|::|          :|:|:||::.:.:  ..:....:.|..:|...:.|...:|.
plant   378 LLEGKSEEMSTSELSGGARIHYIFQSIFVKSLE--EVDPCEDLTDDDIRTAIQNATGPRSALFVP 440

  Fly   682 EAGWEALQQEFIS-LMERSKKAQDHDGIFDQL---------------------KSAVVDEAIRRH 724
            :..:|.|.:..|| |::.|.:....  ||::|                     ...|:.:.:|..
plant   441 DVPFEVLVRRQISRLLDPSLQCARF--IFEELIKISHRCMMNELQRFPVLRKRMDEVIGDFLREG 503

  Fly   725 SWEDKA-----IDMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLV-----------QTEE 773
            ....:|     ||| .:..:||....|:...:..::|:..::||.....|           :|..
plant   504 LEPSEAMIGDIIDM-EMDYINTSHPNFIGGTKAVEAAMHQVKSSRIPHPVARPKQDTVEPDRTSS 567

  Fly   774 TLAQMFGPGQMRR-----ITHWQYLTQDQQKRRSVKNELD---------------KILKN----- 813
            :.:|:.....:.|     :|....::.|.:|.:...|..|               .:.|:
plant   568 STSQVKSRSFLGRQANGIVTDQGVVSADAEKAQPAANASDTRWGIPSIFRGGDTRAVTKDSLLNK 632

  Fly   814 -------DTKH--------------LPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRK-- 855
                   |..|              .||.||.|...|...:        |..:.::::.:.||
plant   633 PFSEAVEDMSHNLSMIYLKEPPAVLRPTETHSEQEAVEIQI--------TKLLLRSYYDIVRKNI 689

  Fly   856 ---------HFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVI 911
                     |||....:|.........||.:...|..:...|.:...|     |.|...|  .|:
plant   690 EDSVPKAIMHFLVNHTKRELHNVFIKKLYRENLFEEMLQEPDEIAVKR-----KRTQETL--HVL 747

  Fly   912 NREARRLDKEIKAVLDEFSDDEEKKGYLLTGKR 944
            .:..|.|| |:....|..|....|...|||..:
plant   748 QQAYRTLD-ELPLEADSVSAGMSKHQELLTSSK 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	86/291 (30%)
DRP3A	NP_001190906.1	DLP_1	57..330	CDD:206738	86/282 (30%)
		Dynamin_M	252..537	CDD:395818	66/319 (21%)
		GED	670..757	CDD:396682	19/102 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910