DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and DL1B

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_191735.2	Gene:	DL1B / 825349	AraportID:	AT3G61760	Length:	610	Species:	Arabidopsis thaliana

Alignment Length:	606	Identity:	149/606 - (24%)
Similarity:	252/606 - (41%)	Gaps:	131/606 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 TMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTL---AEGPYHVAQFRDS 355
            |:.|.||.:.|||.|||||:|||||:......|||:| ::||.|:.:.|   .||..: |:|...
plant    29 TLWDSLPAIAVVGGQSSGKSSVLESVVGKDFLPRGAG-IVTRRPLVLQLHRIDEGKEY-AEFMHL 91

  Fly   356 DREYDLTKESDLQDLRRDVEFRM-KASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTV 419
            .::    |.:|...:|:::.... :.:.|..|.:|...|.:::..|.:..:.||||||:......
plant    92 PKK----KFTDFAAVRQEISDETDRETGRSSKVISTVPIHLSIFSPNVVNLTLVDLPGLTKVAVD 152

  Fly   420 DMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAE 484
            .........|..|.:.::..||.|||.|...:.|...|:...:..:.||.|.||..||||:||.:
plant   153 GQPESIVQDIENMVRSFIEKPNCIILAISPANQDLATSDAIKISREVDPKGDRTFGVLTKIDLMD 217

  Fly   485 E---LADPDRIRKILSGKLFPMKALGY-YAVVTGRGRKD--DSID--AIRQYEEDFFKNS----K 537
            :   ..|      ||.|:.:.::   | :..|..|.:.|  .|:|  |.|:.|.|:|:.|    .
plant   218 QGTNAVD------ILEGRGYKLR---YPWVGVVNRSQADINKSVDMIAARRRERDYFQTSPEYRH 273

  Fly   538 LFHRRGVIMPHQVTSRNLSLAVSDR---FWKMVRETIEQQADAFKATRFNLETEWKN-NFPRLRE 598
            |..|.|.....::.|::|.:.:..|   ...::.:||.:           ||||... ..|...:
plant   274 LTERMGSEYLGKMLSKHLEVVIKSRIPGLQSLITKTISE-----------LETELSRLGKPVAAD 327

  Fly   599 SGR------------DELF------DKAKGEILDEVVT---LSQISAKKWDDALS----TKLWEK 638
            :|.            |:.|      .::.||.::.|..   .:.|...::|..||    .||..:
plant   328 AGGKLYMIMEICRAFDQTFKEHLDGTRSGGEKINSVFDNQFPAAIKRLQFDKHLSMDNVRKLITE 392

  Fly   639 LSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALPA----------KSVEAGWEALQQEFI 693
            ...|   ..:|.|.:.|.:....:.: :.:|..||.|:.|          ||:....|..|...:
plant   393 ADGY---QPHLIAPEQGYRRLIESCL-VSIRGPAEAAVDAVHSILKDLIHKSMGETSELKQYPTL 453

  Fly   694 SLMERSKKAQDHDGIFDQLKSA---VVD--------EAIRR------------HSWEDKAID-ML 734
            .:..........|.:.|:.:.|   :||        |..|:            ||..|:..| .|
plant   454 RVEVSGAAVDSLDRMRDESRKATLLLVDMESGYLTVEFFRKLPQDSEKGGNPTHSIFDRYNDAYL 518

  Fly   735 RVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLV-----QTEETLAQMF----GPGQMRRITHW 790
            |.|..|.|.  :|      :.....|.:|:...:|     :.:.:|..:|    |..:|.:::
plant   519 RRIGSNVLS--YV------NMVCAGLRNSIPKSIVYCQVREAKRSLLDIFFTELGQKEMSKLS-- 573

  Fly   791 QYLTQD---QQKRRSVKNELD 808
            :.|.:|   ||:|.|:...|:
plant   574 KLLDEDPAVQQRRTSIAKRLE 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	85/292 (29%)
DL1B	NP_191735.2	DLP_1	33..300	CDD:206738	84/281 (30%)
		Dynamin_M	222..500	CDD:395818	61/301 (20%)
		GED	513..606	CDD:128597	21/92 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910