Protein Alignment Opa1 and Opa1

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_006522718.2
• Gene: Opa1 / 74143
• MGIID: 1921393
• Length: 1100
• Species: Mus musculus
• Alignment Length: 951
• Identity: 507/951 - (53%)
• Similarity: 668/951 - (70%)
• Gaps: 62/951 - (6%)

  Fly    68 GWQMPPPSRGY--GMLVVRILRGALKLRYIVLGGAIGGGVSLSKKYEEWKDGLP---NFKW---- 123
            |:|   |.|.:  ..|..|:    ||||||:||.|:|||.:..|.::||||.:|   ::||
Mouse   166 GYQ---PRRNFWPARLAARL----LKLRYIILGSAVGGGYTAKKTFDEWKDMIPDLSDYKWIVPD 223

  Fly   124 -------------LEDAMPQGERWSQFSRNLIEVG---SLVKNAIEVDPKLKQLGED-KLSEWRN 171
                         :..|:|..|..:..:.:|.::.   ||:|:.....|||  :.|. ::||...
Mouse   224 FIWEIDEYIDLEKIRKALPSSEDLASLAPDLDKITESLSLLKDFFTAGPKL--VSEVLEVSEALL 286

  Fly   172 WFDSRLDDAIEAADY---------QGV---------QIVETKDDLKAKTTVAALGITSDESRKKY 218
            ...|..:.|..|.|:         :|:         ||.|.:::.:   ..|....||...:|:.
Mouse   287 LLGSPGETAFRATDHGSESDKHYRKGLLGELILLQQQIQEHEEEAR---RAAGQYSTSYAQQKRK 348

  Fly   219 EKLQSQVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLIL-KTNKKTTAKKIKKSLIDMYSEV 282
            ...:.:::.||.|:::.|:|||:.||::||||:|||:  |:| |.:|....:|:|||||||||||
Mouse   349 VSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK--LVLQKDDKGIHHRKLKKSLIDMYSEV 411

  Fly   283 LDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAEGPY 347
            ||.||.||..|...|||||||||||||:|||||||.||:||||||||||||||:||||||:|||:
Mouse   412 LDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPH 476

  Fly   348 HVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPG 412
            |||.|:||.||:|||||.||..||.::|.||:.:|:.|.|||.|.|::.||||||||||||||||
Mouse   477 HVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVLVDLPG 541

  Fly   413 IISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVL 477
            :|:|:|..||.|||::|..::|.||.|||||||||||||||||||.|||||.|.||.||||||||
Mouse   542 VINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRRTIFVL 606

  Fly   478 TKVDLAEE-LADPDRIRKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEEDFFKNSKLFHR 541
            |||||||: :|.|.||::|:.|||||||||||:|||||:|...:||:|||:|||:||:||||. :
Mouse   607 TKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNSKLL-K 670

  Fly   542 RGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFD 606
            ..::..||||:|||||||||.|||||||::|||||:|||||||||||||||:|||||..|:|||:
Mouse   671 TSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDRNELFE 735

  Fly   607 KAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQW 671
            |||.||||||::|||::.|.|::.|...|||::|.:|.|:|||||||:.:..:|||.|||||:||
Mouse   736 KAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQW 800

  Fly   672 AEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRV 736
            .::.||.|:||..||.||:||...| ...|.::||.|||:||.||.:|:|:||.|.|.|.|.|||
Mouse   801 TDKQLPNKAVEVAWETLQEEFSRFM-TEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAEDSLRV 864

  Fly   737 IQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRR 801
            ||.|.||||.:.|||:||:|:.|:|.::..:|..||..:..|.||...:|..:|:..||:|....
Mouse   865 IQHNALEDRSISDKQQWDAAIYFMEEALQGRLKDTENAIENMIGPDWKKRWMYWKNRTQEQCVHN 929

  Fly   802 SVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQRAK 866
            ..||||:|:||.:.:|...|..||:|||||||:...|:||...|:.||..|||:|||:.||....
Mouse   930 ETKNELEKMLKVNDEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTALNHCN 994

  Fly   867 DCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDEFSD 931
            .||:.:|.|.:...:.|:.|:|||||||||:::.||.|.||||:.|.|.|||:|.:|.||::|::
Mouse   995 LCRRGFYYYQRHFIDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVLEDFAE 1059

  Fly   932 DEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQEK 972
            |.|||..|||||||.|||:|.|||:|||||:.||.:|:|||
Mouse  1060 DGEKKVKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	197/274 (72%)
		OPA1_C	629..972	CDD:466080	174/342 (51%)
Opa1	XP_006522718.2	DLP_1	427..701	CDD:206738	195/274 (71%)
		OPA1_C	757..1100	CDD:466080	162/314 (52%)