DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and Dnm1l

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001346936.1	Gene:	Dnm1l / 74006	MGIID:	1921256	Length:	755	Species:	Mus musculus

Alignment Length:	797	Identity:	166/797 - (20%)
Similarity:	299/797 - (37%)	Gaps:	220/797 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 LPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLA--------------EGPY-- 347
            ||::||||.|||||:|||||:....:.|||:| ::||.|:.:.|.              .|.:
Mouse    25 LPQIVVVGTQSSGKSSVLESLVGRDLLPRGTG-VVTRRPLILQLVHVSPEDKRKTTGEENGKFQS 88

  Fly   348 ----------HVAQFRDSDR--EYDLTKE---SDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTV 397
                      |:::..:::.  ::..||.   :|..::|:::|...:......|.||.|.|.:.|
Mouse    89 WNPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKV 153

  Fly   398 KGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDL 462
            ..|.:..:.||||||:......|...|.:..|.::...::||||:|||.:...:.|...|....:
Mouse   154 FSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKI 218

  Fly   463 VMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGR----GRKDDSID 523
            ..:.||.||||:.|:||:||.:...|   ...:|.|::.|:| ||...||...    ..|....|
Mouse   219 SREVDPDGRRTLAVITKLDLMDAGTD---AMDVLMGRVIPVK-LGIIGVVNRSQLDINNKKSVTD 279

  Fly   524 AIRQYEEDFFKNSK---LFHRRG----------VIMPH------QVTSRNLSLAVSDRFWKMVRE 569
            :||  :|..|...|   |.:|.|          ::|.|      ::.:|...||..   ::.:..
Mouse   280 SIR--DEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQ---YQSLLN 339

  Fly   570 TIEQQADAFKATRFNLETEWKNNFPRLRES-----GRDEL---------FDKAKGEILDEVVTLS 620
            :..:..|...||...|.|::...:....|.     ...||         |.:..|..|:.|..|.
Mouse   340 SYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLG 404

  Fly   621 QISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSVEAGW 685
            .::......|:......:      .::::|      :.||..:|..::::..|.:|  :.||...
Mouse   405 GLNTIDILTAIRNATGPR------PALFVP------EVSFELLVKRQIKRLEEPSL--RCVELVH 455

  Fly   686 EALQQ-----EFISLMERSKKAQDHDGIFD------QLKSAVVDEAIRRHSWEDKAIDMLRVIQL 739
            |.:|:     ...|..|..:..:.||.|.:      :.:..|.:|.:..       :..:.:..:
Mouse   456 EEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHN-------LVAIELAYI 513

  Fly   740 NTLEDRFVH---------DKQEWDSAVKFLES-----------SVNAKLVQTEETLAQMFGPGQM 784
            ||....|..         ::|..:...:.|.|           |..|...|.....|.....|:
Mouse   514 NTKHPDFADACGLMNNNIEEQRRNRLARELPSAGSRDKSSKVPSALAPASQEPPPAASAEADGK- 577

  Fly   785 RRITHWQYLTQDQQKRRSVKN---------------------------ELDKILKND-TKHLPTL 821
                    |.||  .||..||                           :.:::|..: :|.:|.:
Mouse   578 --------LIQD--NRRETKNVPSAGGGIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIM 632

  Fly   822 THDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCR------KAYYLYTQQGA 880
            .    .:.:|....:.:||..        ||.||    .:.:..:||.      |:|:|..::..
Mouse   633 P----ASPQKGHAVNLLDVPV--------PVARK----LSAREQRDCEVIERLIKSYFLIVRKNI 681

  Fly   881 ECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEI------KAVLDEFSDDEEKKGYL 939
            :..:.                  .|:...::|.....|..|:      .::||:...:.|.
Mouse   682 QDSVP------------------KAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESED---- 724

  Fly   940 LTGKRVLLAEELIKVRQ 956
             ..:|...|.:::|..|
Mouse   725 -MAQRRKEAADMLKALQ 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	91/326 (28%)
Dnm1l	NP_001346936.1	DLP_1	23..321	CDD:206738	88/302 (29%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	32..39		5/6 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	58..60		0/1 (0%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	165..168		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	234..237		2/2 (100%)
		Dynamin_M	245..528	CDD:307257	57/309 (18%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	264..267		1/2 (50%)
		Middle domain. /evidence=ECO:0000250\|UniProtKB:O00429	363..508		26/165 (16%)
		Interaction with GSK3B. /evidence=ECO:0000250\|UniProtKB:O00429	467..704		43/288 (15%)
		B domain. /evidence=ECO:0000250\|UniProtKB:O00429	521..588		13/77 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	541..573		6/31 (19%)
		C-terminal dimerization domain. /evidence=ECO:0000250	561..755		36/230 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..607		2/21 (10%)
		GED	661..749	CDD:308047	16/103 (16%)
		Important for homodimerization. /evidence=ECO:0000250\|UniProtKB:O00429	673..687		2/31 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900