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Protein Alignment Opa1 and Mfn1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_077162.2	Gene:	Mfn1 / 67414	MGIID:	1914664	Length:	741	Species:	Mus musculus

Alignment Length:	802	Identity:	161/802 - (20%)
Similarity:	266/802 - (33%)	Gaps:	246/802 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 LDELSGYDT-----GYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTL 342
            |.|:.||..     |..::....:|...|..||||:||:.::...::.|.|.|. .|...:.|
Mouse    54 LVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-TTNCFLSV-- 115

  Fly   343 AEGPYHVAQFRDSDREYDLTKESDLQDLRRDVE-----FRMKASVRGGKTVSNEVIAMTVKGPGL 402
             ||       .|.|:.|.:|:.||.:...:.|.     ..|...::.|..|  .|.....|...|
Mouse   116 -EG-------TDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLV--HVFWPKAKCALL 170

  Fly   403 Q-RMVLVDLPGIISTMTVD--------------MASDTKDSIHQMTKHY-------MSNPNAIIL 445
            : .:||||.||...|..:|              :.::::.::....||:       :|.||..||
Mouse   171 RDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFIL 235

  Fly   446 CIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRI-----RKILSGKLFPMKA 505
            ..:..:..:|...:.|:..|  .:.|...|::.::.:.......:||     :::|:.:....:.
Mouse   236 NNRWDASASEPEYMEDVRRQ--HMERCLHFLVEELKVVSPSEARNRIFFVSAKEVLNSRKHKAQG 298

  Fly   506 L--GYYAVVTGRGRKDDSIDAIRQYEEDFFKNS--KLFHRRGVIMPHQV--TSRNL-----SLAV 559
            :  |..|:..|...:........|..|:....|  |....:..|...|:  |.:|:     ..|.
Mouse   299 MPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAA 363

  Fly   560 SDRFWKMVRETIEQQADA--FKATRFNLET-EWKNNFPRLRESGRDELFDKAKGEILDEVVTLSQ 621
            ..|.:.|  |..|.|.|.  |...:.||.| :.|.....:.|    |:.:|....:.||:..||.
Mouse   364 EKRVYSM--EEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTE----EVANKVSCAMTDEICRLSV 422

  Fly   622 I---------------------SAKKWDDALSTKLWEKLSNYVFESI----------YLPAAQSG 655
            :                     ..|..:|.:...|.::.:|.|..||          ..|...:|
Mouse   423 LVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTNEVNASILQSQQEIIENLKPLLPAG 487

  Fly   656 SQNSFNTMVDIK-------------LRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQD--- 704
            .||..:|::..|             ...:.|..:...|:  ||.:|...|:.    |..||.
Mouse   488 IQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSL--GWSSLVHRFLG----STNAQRVLL 546

  Fly   705 --HDGIFDQLKS-----------AVVDEAIRRHSWEDKAIDMLRVIQLNTLEDR-----FVHDKQ 751
              .:.||...:|           |..|.|.:    |:..|.:  :..|.:|..|     .|....
Mouse   547 GLSEPIFQVPRSLASTPTAPSNPAAPDNAAQ----EELMITL--ITGLASLTSRTSMGIIVVGGV 605

  Fly   752 EWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNELDKILKNDTK 816
            .|        .:|..||:..  ||: |:|.         .||
Mouse   606 IW--------KTVGWKLISV--TLS-MYGA---------LYL----------------------- 627

  Fly   817 HLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFP-VYRKHFLQQALQRAKDCRKAYYLYTQQGA 880
                                       |.|.||.. ...:.|.||.:..|.:..:....:|....
Mouse   628 ---------------------------YERLTWTTRAKERAFKQQFVNYATEKLQMIVSFTSANC 665

  Fly   881 ECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDEFSDDEEK---KGYLLTG 942
            ..::.......|.|:.|.:.:|     |:.:..|..||.|||        |..||   ...||..
Mouse   666 SHQVQQEMATTFARLCQQVDVT-----QKHLEEEIARLSKEI--------DQLEKIQNNSKLLRN 717

  Fly   943 KRVLLAEELIKVRQIQEKLEEF 964
            |.|          |::.:||.|
Mouse   718 KAV----------QLESELENF 729

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.