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Protein Alignment Opa1 and Mfn2

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_570964.4	Gene:	Mfn2 / 64476	RGDID:	628843	Length:	757	Species:	Rattus norvegicus

Alignment Length:	853	Identity:	164/853 - (19%)
Similarity:	314/853 - (36%)	Gaps:	251/853 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 NVQIKYQKELEKMEKENRELRQQYLILKTNKKTTAKKIKKSLIDMYSEVLDELSGY--DT----- 291
            |..:..:|:...|.:.|....:.::        ||||....:.:.....:.|.:|:  ||
  Rat     9 NSIVTVKKDKRHMAEVNASPLKHFV--------TAKKKINGIFEQLGAYIQESAGFLEDTHRNTE 65

  Fly   292 --------------GY---------TMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMM 333
                          ||         .:|....:|...|..|:||::|:.::...::.|.|.|. .
  Rat    66 LDPVTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGH-T 129

  Fly   334 TRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVE-----FRMKASVRGGKTVSNEVI 393
            |...::|...:|  |.|        :.||:.|:.:...:.|.     ......:..|..||  |:
  Rat   130 TNCFLRVGGTDG--HEA--------FLLTEGSEEKKSVKTVNQLAHALHQDEQLHAGSLVS--VM 182

  Fly   394 AMTVKGPGLQ-RMVLVDLPGIISTMTVD--------------MASDTKDSIHQMTKHY------- 436
            ....|.|.|: .:||:|.|||..|..:|              :.::::.::.|..|.:
  Rat   183 WPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQFFHKVSER 247

  Fly   437 MSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRI-----RKIL 496
            :|.||..||..:..:..:|...:.::..|  .:.|.|.|::.::.:.:.....|||     :::|
  Rat   248 LSRPNIFILNNRWDASASEPEYMEEVRRQ--HMERCTSFLVDELGVVDRAQAGDRIFFVSAKEVL 310

  Fly   497 SGKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEEDFFKNSKLFHRR-----------GVIMPHQV 550
            |.::  .||.|   :..|.|...:... :|.:|   |:|   |.||           .....|.|
  Rat   311 SARV--QKAQG---MPEGGGALAEGFQ-VRMFE---FQN---FERRFEECISQSAVKTKFEQHTV 363

  Fly   551 TSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDEL-FDKAKGEIL- 613
            .::.::.||     :::.:::...|...:.  :.||         :||..:|.| |...:.|:|
  Rat   364 RAKQIAEAV-----RLIMDSLHIAAQEQRV--YCLE---------MREERQDRLRFIDKQLELLA 412

  Fly   614 -DEVVTLSQISAKKWDDALSTKLWEKL-------SNYVFESIYLPAAQSGSQNSFNTMVDIKL-R 669
             |..:.:.|:: ::.:..:||.:.|::       ..|..:....|......:|..:..::..| |
  Rat   413 QDYKLRIKQMT-EEVERQVSTAMAEEIRRLSVLVDEYQMDFHPSPVVLKVYKNELHRHIEEGLGR 476

  Fly   670 QWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDML 734
            ..:::.  :.::.:..:.:||:.|            ||:...|..:|.::           ||||
  Rat   477 NMSDRC--STAIASSLQTMQQDMI------------DGLKPLLPVSVRNQ-----------IDML 516

  Fly   735 RVIQLNTLE-----DRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLT 794
            ...|..:|.     |:...|.||   .::|..|.....||.      :..||...||    ..|.
  Rat   517 VPRQCFSLSYDLNCDKLCADFQE---DIEFHFSLGWTMLVN------RFLGPKNSRR----ALLG 568

  Fly   795 QDQQKRRSVKNELDKILKNDTKHLP-----TLTHDEL-----TTVRKNLQRDNVDVDT------- 842
            .:.|.:|.:.      |......:|     :||.:||     |.:.....|.::.:..
  Rat   569 YNDQVQRPLP------LTPANPSMPPLPQGSLTQEELMVSMVTGLASLTSRTSMGILVVGGVVWK 627

  Fly   843 ------------------DYIRQTWFP-----VYRKHFLQQALQRAKDCRKAYYLYTQQGAECEI 884
                              .|.|.||..     .:::.|::.|.:      |...:.:..|:.|.
  Rat   628 AVGWRLIALSFGLYGLLYVYERLTWTTRAKERAFKRQFVEYASE------KLQLIISYTGSNCS- 685

  Fly   885 SCSDVVLFWRIQQVIKITGNALRQQV------INREARRLDKEIKAVLDEFSDDEEKKGYLLTGK 943
                    .::||.:..|...|.|||      :.:|...::|:::|:     |..:.|..||..|
  Rat   686 --------HQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEAL-----DSLQSKAKLLRNK 737

  Fly   944 RVLLAEEL 951
            ...|..||
  Rat   738 AGWLDSEL 745

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.