Protein Alignment Opa1 and mfn2

DIOPT Version :9

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_001121726.1
• Gene: mfn2 / 567448
• ZFINID: ZDB-GENE-081105-44
• Length: 757
• Species: Danio rerio
• Alignment Length: 888
• Identity: 178/888 - (20%)
• Similarity: 315/888 - (35%)
• Gaps: 299/888 - (33%)

  Fly   234 NVQIKYQKELEKMEKENRELRQQYLILKTNKKTTAKK------------IKKS---LIDMYS-EV 282
            |..:..:|:...|.:.|....:.::        ||||            ||:|   |.:.|| |.
Zfish     9 NTSVIGKKDKRLMAEVNASPLKHFV--------TAKKKINGIFEQLGAYIKESSAFLEETYSNEE 65

  Fly   283 LD---------ELSGY-----DTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMM 333
            ||         |:.||     ..|..::....:||..|..|:||:||:.::...::.|.|.|. .
Zfish    66 LDPVTTEEQVAEVRGYLSKVAGIGEVLSRRHMKVVFFGRTSNGKSSVINAMLWDKVLPSGIGH-T 129

  Fly   334 TRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAM--- 395
            |...::|   ||       .|.:..:.||:.|   |.|:.|           |||:....|:
Zfish   130 TNCFLRV---EG-------TDGNESFLLTEGS---DERKSV-----------KTVNQLAHALHQD 170

  Fly   396 ---------TVKGP----GLQR--MVLVDLPGIISTMTVD--------------MASDTKDSIHQ 431
                     .|..|    .|.|  :||||.|||..|..:|              :.::::.::.|
Zfish   171 EDLDAGSLVCVMWPKAKCALLRDDLVLVDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQ 235

  Fly   432 MTKHY-------MSNPNAIILCIQDGSVDAERSNVTDLV--MQCDPLGRRTIFVLTKVDLAEELA 487
            ..|.:       :|:||..||   :...||. :|..:.:  ::...:.|.|.|::.::.:.:...
Zfish   236 TEKSFFHKVNERLSSPNIFIL---NNRWDAS-ANEPEYMEEVRRQHMDRCTSFLVDELRVVDRSH 296

  Fly   488 DPDRI-----RKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEEDFFKNSKLFHRR----- 542
            ..|||     :::|..::  .||.|   :....|...:...| |.:|   |:|   |.||
Zfish   297 AGDRIFFVSAKEVLQARV--QKAQG---MPEAGGALAEGFQA-RMFE---FQN---FERRFEECI 349

  Fly   543 ------GVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGR 601
                  .....|...::.:|.|:     :::.:::...|.           |.:.:...::|...
Zfish   350 SQSAVKTKFEQHTTRAKQISEAL-----RLIMDSVHIAAQ-----------EQRIHCLEMKEERE 398

  Fly   602 DELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIY---------------LPA 651
            |.|      |.:|:.:.|..:..|.....::.::.:::||.:.|.|.               .|.
Zfish   399 DRL------EFIDKQLDLLTLDCKSKIKKITEEVEKQVSNAMAEEIRRLAVLVDDFHMDFHPSPV 457

  Fly   652 AQSGSQNSFNTMVDIKL-RQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSA 715
            .....:|..:..::..| |..:|:...|.:|     |||.....::         ||:...|...
Zfish   458 VLKVYKNELHRHIEEGLGRNMSERCSSAITV-----ALQTTQTDMI---------DGLKPLLPIT 508

  Fly   716 V---VDEAIRRHSWEDKAIDMLRVIQLNTLEDRFVHDKQE---------WDSAV-KFLESSVNAK 767
            :   ||:.:.|..:   |:.    ..||.  |:...|.||         |...| :||
Zfish   509 IREQVDKMVPRQCF---ALS----YDLNC--DKLCSDFQEDIGFHFSLGWTMLVNRFL------- 557

  Fly   768 LVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNELDKILKNDTKHLP----TLTHDEL-- 826
                        ||...||    ..:..:.|..||:     .|....|...|    ::|.:||
Zfish   558 ------------GPKNTRR----ALMGYNDQVPRSL-----AITPVSTSMPPFPQGSMTQEELMV 601

  Fly   827 ---TTVRKNLQRDNVDVDT-------------------------DYIRQTWFP-----VYRKHFL 858
               |.:.....|.::.:..                         .|.|.||..     .:::.|:
Zfish   602 SMVTGLASLTSRTSMGIIVVGGVIWKAVGWRLIALSVGLYGLLYVYERLTWTTRAKERTFKRQFV 666

  Fly   859 QQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQV-INREARRLDKEI 922
            ..|.:      |...:.:..|:.|.         .::||.:..|.:.|.||| :.|:  :|:.||
Zfish   667 DYASE------KLQLIVSYTGSNCS---------HQVQQELASTFSQLCQQVDVTRQ--QLEDEI 714

  Fly   923 KAVLDEFS--DDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEE 963
            ..:..:..  |..:.|..||..|...|..||...  ||:.|::
Zfish   715 GDLNSKIEQLDTLQSKAKLLRNKAGWLDSELNMF--IQQYLQQ 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	71/330 (22%)
mfn2	NP_001121726.1	DLP_2	97..349	CDD:206739	68/292 (23%)
		Fzo_mitofusin	594..754	CDD:282633	35/178 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900