DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and mxh

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_009296275.1	Gene:	mxh / 562203	ZFINID:	ZDB-GENE-131126-68	Length:	644	Species:	Danio rerio

Alignment Length:	725	Identity:	164/725 - (22%)
Similarity:	303/725 - (41%)	Gaps:	166/725 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 YSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTL- 342
            |.|::|.:........:|  ||.:.|||||||||:||||:::...: ||||| ::||.|:::.|
Zfish    35 YIEMIDFMRRIGIERELA--LPAIAVVGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLELKLR 95

  Fly   343 --AEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRM 405
              :.|....|....:|......:.:.::...|..:..:...   |..:.:::|::.:..|.:..:
Zfish    96 KMSSGSGWTAVISYNDVRETFHEPAQVESFVRKAQNMLAGD---GVGICDDLISLEITSPDVCDL 157

  Fly   406 VLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLG 470
            .|:|||||..........|..|.|.::...:::....|.|.:...:||...:....:....||.|
Zfish   158 TLIDLPGITRVPVKGQPEDIGDQIRRLILKFIAKKETINLVVVPCNVDIATTEALRMAQGVDPDG 222

  Fly   471 RRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD--DSI---DAIRQYEE 530
            .||:.:|||.||.::.|:.| |.::|.||:.|:|.  .|.:|..||:.|  :::   :|.|| |:
Zfish   223 SRTLAILTKPDLVDKGAEAD-ILQVLQGKVVPLKK--GYTIVRCRGQSDINENVSLSEATRQ-EK 283

  Fly   531 DFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPR 595
            :||.|..  |...::...:.|:..||.       ::.:|.:|.    .||.          :.|.
Zfish   284 EFFSNHP--HFSYLLEEQRATTSCLST-------RLTKELVEH----IKAA----------SLPS 325

  Fly   596 LRE-------SGRDELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQ 653
            ||:       :.|.||...|.|..|:         .::....||.|:.| .|:.:.|......::
Zfish   326 LRDQIHINLSAVRIELRSYADGPPLE---------TERMGPYLSKKILE-FSDQISELCRTGESE 380

  Fly   654 SGSQNSFNTMVDIKLRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDG----IFDQLKS 714
            :|:..|....|   .:||......:|       ||.:|.:..|..:.. :.|.|    .|...
Zfish   381 TGNLYSLLRPV---FKQWECHLSNSK-------ALFRESVKEMTENYD-EGHRGRELVTFSDY-- 432

  Fly   715 AVVDEAIRRHSWEDK--AIDMLRVIQ-------------------------LNTLEDRFVHDKQE 752
            .|.:..::||..:.|  |::.|::|:                         .|.:::  :|.|||
Zfish   433 CVYESMVKRHVGDLKQPAMETLKLIRGIVQKEFRVMCELCFPNYPHLRHIIQNHIDE--IHSKQE 495

  Fly   753 WDSAVKFLESSVN-AKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNELDKILKNDTK 816
             ....|.:...:| .|||.|::       |...::|..::::    :||:..::     :..||.
Zfish   496 -SKVEKRIHEYINMEKLVYTQD-------PIFTQKIVDFKFV----EKRQEYES-----VTLDTG 543

  Fly   817 HLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCRKAYYLYTQQGAE 881
            ...|..|:......:||..|.:.:..:.:.|                     |.|.|:
Zfish   544 EDATSPHNCAVFDTRNLTPDKLIIYYEIVYQ---------------------RLADYI------- 580

  Fly   882 CEISCSDVVLFWRIQQVIKITGNALRQQVIN-REARRLDKEIKAVLDEFSDDEEKKGYL-LTGKR 944
                 ..|:|.:.:::...:    ||.|.:: ||.    .::..:|.|.|:..:|:..| ...:|
Zfish   581 -----PMVILLFMLKEAAVM----LRAQAMDLREG----ADVVKLLMEDSEAGQKRSELHQRMER 632

  Fly   945 VLLAEELIKV 954
            :.||:|.|.:
Zfish   633 LRLAQERISI 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	79/281 (28%)
mxh	XP_009296275.1	DLP_1	51..324	CDD:206738	83/306 (27%)
		Dynamin_M	244..519	CDD:279383	72/333 (22%)
		GED	568..641	CDD:295362	20/113 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000