Protein Alignment Opa1 and mxf

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_017206546.2
• Gene: mxf / 561067
• ZFINID: ZDB-GENE-030721-9
• Length: 646
• Species: Danio rerio
• Alignment Length: 706
• Identity: 155/706 - (21%)
• Similarity: 280/706 - (39%)
• Gaps: 187/706 - (26%)

  Fly   250 NRELRQQYLILKTNKKTTAKKIK-----------KSLIDMYSEV----LDELSGYDTGYTMADHL 299
            |:|...:|.........:..|.:           :.||::...:    |||    |.|      |
Zfish     2 NQEKHSEYYYQGDESSFSGSKAQEGPQNHFLESVRPLIELIDSLRFIGLDE----DIG------L 56

  Fly   300 PRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAE---GPYHVAQFRDSDREYDL 361
            |.:.|||||||||:||||:::...: ||||| ::||.|:::.|.:   ||:      .....||.
Zfish    57 PSIAVVGDQSSGKSSVLEALSGVAL-PRGSG-IVTRCPLELKLQKIKTGPW------SGTISYDG 113

  Fly   362 TKESDLQDLRRDVEFRMKASVRGGKTVS--NEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASD 424
            .||:....|:.|...|.......|.||.  :|:|.:.:..|.:..:.|:|||||..........|
Zfish   114 HKEAFSDPLKVDSLVRAAQDDLAGTTVGICDELITLEISSPDVCDLTLIDLPGITRVPVNGQPDD 178

  Fly   425 TKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADP 489
            ..|.|..:...|:.....|||.:...:||...:....:..|.||.|.||:.:|||.||.:..|:.
Zfish   179 IGDQIKSLILKYIDKSETIILVVVPCNVDIATTEALRMAQQVDPEGLRTLAILTKPDLIDRGAEI 243

  Fly   490 DRIRKILSGKLFPMKALGYYAVVTGRGRKDDS----IDAIRQYEEDFFKNSKLFHRRGVIMPHQV 550
            | :..|:.||:.|:..  .|.:|..||:.|.:    .:...:.|::||::...|  ..::.....
Zfish   244 D-VLNIVQGKVIPLSK--GYIIVRCRGQSDINNRVPFEKAMEDEQNFFRSHHYF--SSLLADGNA 303

  Fly   551 TSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKN--NFPRLRESGRDELFDKAKGEIL 613
            :::.|:|.::......::::|....:..:....|::.|.||  ..|.:.|    ||......||:
Zfish   304 STQCLALKLTRELGDHIKKSIPTLTEEIQNKVLNVQRELKNYDQGPPMNE----ELMGPFLSEII 364

  Fly   614 ----DEVVTLSQIS--------------AKKWDDALST-------KLWEKLSNY----------- 642
                |::..||:..              .:|||:.|.:       ::.|.:..|
Zfish   365 LNFSDQINELSRTGHSQDKNLYTLLRPVFRKWDNHLRSTEVLFKERVTEMIEKYNEIHRGRELLT 429

  Fly   643 -----VFESI---YLPAAQSGSQNSFNTMVDIKLRQWAE-------QALPAKSV----------- 681
                 .:|.:   ::.|.|..:..:.|.:.:|...::.|       |..|.:.:
Zfish   430 FSEFCEYECVIQNHVAALQEPAMETLNDVREIVQNKFREACYLSFDQYPPMRYIISNMINDIQSK 494

  Fly   682 -EAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQLNTLEDR 745
             ||..|...:|||: ||:....|      |::....:|::           |:...:.|||
Zfish   495 QEAKAEKRIKEFIN-MEQLVFTQ------DKVLQKKLDDS-----------DIPPKMGLNT---- 537

  Fly   746 FVHDKQEWDSAVKFLESSVNAKLVQTEETLAQ---MFGPGQMRRITHW----------------- 790
              .|:.::|..:.|  :|....::.|.:.:.:   ::.....:|:|.:
Zfish   538 --SDRNQYDEDMVF--NSKGCAMLDTRDLVTEKMVLYYEIVYQRLTDYVPMLITLFMLKDAAKTL 598

  Fly   791 --------------QYLTQDQQKRRSVKNELDKILKNDTKH-LPTLTH-DELTTVR 830
                          :.|::|.::.|         ::.|.|| |..||. .||.:.|
Zfish   599 RHQMLELRNGADVPKLLSEDSERER---------IRADLKHRLERLTQAQELISTR 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	82/282 (29%)
		OPA1_C	629..972	CDD:466080	45/283 (16%)
mxf	XP_017206546.2	DLP_1	56..325	CDD:206738	82/281 (29%)
		Dynamin_M	244..524	CDD:460033	54/295 (18%)
		GED	570..644	CDD:470615	13/82 (16%)