Protein Alignment Opa1 and dnm2a

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_068073278.1
• Gene: dnm2a / 559334
• ZFINID: ZDB-GENE-050913-84
• Length: 903
• Species: Danio rerio
• Alignment Length: 819
• Identity: 171/819 - (20%)
• Similarity: 315/819 - (38%)
• Gaps: 174/819 - (21%)

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:::.|..|  ..|.:....||::.|||.||:||:||||:.......||||| ::||.|
Zfish     7 EELIPLINKLQDAFS--SIGQSCNLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|......    |..|..::|:::|..........|.:|...|.:.|..|.:
Zfish    69 LILQLVNNKAEYAEFLHCKGR----KFVDFDEVRQEIEAETDRITGSNKGISPIPINLRVYSPNV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:||||:......|...|.:..|..|...:::..:.:||.:...::|...|:...:..:.|
Zfish   130 LNLTLIDLPGMTKVAVGDQPPDIEHQIRDMIMQFITRESCLILAVTPANMDLANSDALKVAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGR-----GRKDDSIDAIRQ 527
            |.|.|||.|:||:||.:|..|   .|.||..||.|::. ||..||...     ||||  |.|...
Zfish   195 PQGLRTIGVITKLDLMDEGTD---ARDILENKLLPLRR-GYIGVVNRSQKDIDGRKD--IRAALA 253

  Fly   528 YEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLE---TEW 589
            .|..||    |.|.....|..::.:.:|..|::.:....:|:|:.......::...:||   .|:
Zfish   254 AERKFF----LSHPSYRHMAERMGTPHLQKALNQQLTNHIRDTLPGLRSKLQSQLLSLEKEVEEY 314

  Fly   590 KNNFP------------RLRESGRDELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNY 642
            ||..|            .:::.|.|  |:|......|:|.|.......:.:.....:...:|...
Zfish   315 KNFRPDDPTRKTKALLQMVQQFGVD--FEKCIEGSGDQVDTAELSGGARINRIFHERFPFELVKI 377

  Fly   643 VFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSV----------EAGWEAL-QQEFISLM 696
            ||:                   :.:||:....|:  |:|          :..:||: :::.|.|.
Zfish   378 VFD-------------------EKELRREISHAI--KNVHGVRTGLFTPDLAFEAIVKKQIIKLK 421

  Fly   697 ERSKKA-----QDHDGIFDQLKS-------------AVVDEAIRRHSWEDKAIDMLRVI------ 737
            |...|.     |:....|.|..:             .:|...:|..  |.|..|.:.::
Zfish   422 EPCLKCIDLVIQELINTFRQCTNKLSSYPRLREETERIVTTYVRER--EGKTKDQVLLLIDTELS 484

  Fly   738 QLNTLEDRFVH----DKQEWDSAV--KFLESSVNAK-LVQTEETLAQMFG---PGQMRRI----- 787
            .:||..:.|:.    |.:..|...  .:..:|...: :|..:..:....|   .|:..::
Zfish   485 YINTNHEDFIGFANLDLRRLDDGTIPGYSNNSAQQRNIVNKKRAIPNQLGGLREGEAEKVIRKGW 549

  Fly   788 -------------THWQYLTQDQ--------------------------QKRRSVKNELDKILKN 813
                         .:|..||.:.                          :|.:.....||.:...
Zfish   550 LTLNISIMKGGSKEYWFVLTAESLSWYKDEEINKNVHLTCFFNICKHITEKEKKYMLPLDNLKLR 614

  Fly   814 D-------TKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCRKA 871
            |       |||:..:.:.|...|.|:|::..:..|:.....:|    :..||:..:...||
Zfish   615 DVEKGFMSTKHIFAIFNTEQRNVYKDLRQIELACDSQEDMDSW----KASFLRAGVYPEKD---- 671

  Fly   872 YYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRL-DKEIKAVLDEFSDD--- 932
             .:.:::.|..:....|..|..:::.:..:..:.:  .::|:..|.| .|.|..::...:.|
Zfish   672 -QVESEEAAPADSFSMDPQLERQVETIRNLVDSYI--GIVNKTIRDLMPKTIMHLMINSAKDFIH 733

  Fly   933 EEKKGYLL-TGKRVLLAEELIKVRQIQEKLEEFINSLNQ 970
            .|...||. :|.:..|.||.....|.::::....:::.:
Zfish   734 SELLAYLYSSGDQNSLMEESADQAQRRDEMLRMYHAIKE 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	85/278 (31%)
		OPA1_C	629..972	CDD:466080	68/443 (15%)
dnm2a	XP_068073278.1	DYNc	6..245	CDD:197491	74/248 (30%)
		Dynamin_M	215..498	CDD:460033	65/317 (21%)
		PH_dynamin	544..670	CDD:269958	18/129 (14%)
		GED	690..780	CDD:460495	15/85 (18%)
		PHA03247	<782..900	CDD:223021