Protein Alignment Opa1 and dnm3a

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_001121996.1
• Gene: dnm3a / 557996
• ZFINID: ZDB-GENE-040724-76
• Length: 825
• Species: Danio rerio
• Alignment Length: 801
• Identity: 175/801 - (21%)
• Similarity: 298/801 - (37%)
• Gaps: 201/801 - (25%)

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:.:.|..|.  .|......||::.|||.||:||:||||:.......||||| ::||.|
Zfish     7 EELIPLVNRLQDAFSA--IGQNCDLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|..|:||::|..........|.:|:..|.:.|..|.:
Zfish    69 LVLQLISSASEHAEFLHCKGK----KFTDFDDVRREIEAETDRVTGTNKGISSIPINLRVFSPNV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:|||||......|..:|.:..|..|...::...|.:||.:...::|...|:...|....|
Zfish   130 LNLTLIDLPGITKVPVGDQPADIEYQIRDMIMQFICKENCLILAVTPANMDLANSDALKLAKDVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQY 528
            |.|.|||.|:||:||.::..|   :|.:|..:|.|::. ||..|| .|.:||    ..|.|....
Zfish   195 PQGHRTIGVITKLDLVDKGTD---VRDVLENRLLPLRR-GYIGVV-NRSQKDIEGKKDISAALAA 254

  Fly   529 EEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRET--------------IEQQADAFK 579
            |:.|||:...:......|......|.|:..:::.    :|:|              ::::|:.:|
Zfish   255 EKRFFKSHPAYRHMADYMGTPYLQRLLNQQLTNH----IRDTLPALRSRLQAQLLSLDKEAEEYK 315

  Fly   580 A-----------------TRFNLETEWKNNFPRLRESGRDEL--------------------FDK 607
            .                 ..|.|:.|     .|:..|| |::                    |:.
Zfish   316 GLNPDDPSRKTKALMQLIQHFGLDFE-----KRIEGSG-DQVDTVQLSGGAKINRIFHERFPFEL 374

  Fly   608 AKGEILDEVVTLSQIS-AKKWDDALSTKLWEKLSNYVFESIY-----------LPAAQSGSQNSF 660
            .|.| .||.....:|| |.|....:.|.|:  ..:..||:|.           |.......|...
Zfish   375 VKME-FDEKELRREISYAIKNIHGIRTGLF--TPDMAFEAIVKKQIVKLKGPCLKCVDMVIQELI 436

  Fly   661 NTMVDI--------KLRQWAEQALPAKSVEAGWEALQQEFISL-MERSKKAQDHDGIF------- 709
            ||:...        |||:..|:.:.....|...:...|..:|| ::.|....:|:...
Zfish   437 NTVQQCTNKLESFPKLREETERIVTTHIRERESQTKDQVLLSLEIQLSYINTNHEDFIGFANAQQ 501

  Fly   710 --DQL--KSAVVDEAIRRHSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQ 770
              .||  |.:..::.||: .|          :.:|.:.......|:.|              .|.
Zfish   502 KTSQLSNKPSAGNQVIRK-GW----------VIINNISLIKGGSKEYW--------------FVL 541

  Fly   771 TEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTT 828
            |.|:|:               :...|::|.:.....||.:...|       :||:..:.:.|...
Zfish   542 TAESLS---------------WFKDDEEKEKKYMLPLDNLKVRDIEKSFMSSKHVFAIFNTEQRN 591

  Fly   829 VRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCRKAYYLYTQQ-------GAECEISC 886
            |.|:.:...:..||.....:|         :.:|.||.       :|.::       .::.|...
Zfish   592 VYKDYRHLELACDTQDDVDSW---------KASLLRAG-------VYPEKTTADGDGSSQTESFS 640

  Fly   887 SDVVLFWRIQQV-------IKITGNALR--------QQVINREARRLDKEIKAVL----DEFSDD 932
            .|..|..:::.:       :.|...::|        ..|||.....:..|:.|.|    |::|..
Zfish   641 MDPQLERQVETIRNLVDSYMSIVYKSIRDLMPKTIMHLVINNVEEFIHSELLAQLYSSGDQYSLM 705

  Fly   933 EEKKGYLLTGKRVLLAEELIK 953
            :|.....|..:.||.....:|
Zfish   706 DESPEQALRREEVLRTHAALK 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	85/291 (29%)
		OPA1_C	629..972	CDD:466080	67/389 (17%)
dnm3a	NP_001121996.1	DYNc	6..245	CDD:197491	79/249 (32%)
		Dynamin_M	215..502	CDD:460033	60/304 (20%)
		PH_dynamin	514..625	CDD:269958	27/166 (16%)
		GED	645..730	CDD:460495	16/82 (20%)