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Protein Alignment Opa1 and MFN1

DIOPT Version :10

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_284941.2	Gene:	MFN1 / 55669	HGNCID:	18262	Length:	741	Species:	Homo sapiens

Alignment Length:	823	Identity:	167/823 - (20%)
Similarity:	275/823 - (33%)	Gaps:	270/823 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 LDELSGYD-----TGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTL 342
            |.|:.||.     .|..::....:|...|..||||:||:.::...::.|.|.|. :|...:.|
Human    54 LVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-ITNCFLSV-- 115

  Fly   343 AEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAM----TVKGPGLQ 403
             ||       .|.|:.|.:|:.||           .|.||   |||:....|:    .:|...|.
Human   116 -EG-------TDGDKAYLMTEGSD-----------EKKSV---KTVNQLAHALHMDKDLKAGCLV 158

  Fly   404 R--------------MVLVDLPGIISTMTVD--------------MASDTKDSIHQMTKHY---- 436
            |              :||||.||...|..:|              :.::::.::....||:
Human   159 RVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKV 223

  Fly   437 ---MSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRI-----R 493
               :|.||..||..:..:..:|...:.|:..|  .:.|...|::.::.:...|...:||     :
Human   224 NERLSKPNIFILNNRWDASASEPEYMEDVRRQ--HMERCLHFLVEELKVVNALEAQNRIFFVSAK 286

  Fly   494 KILSGKLFPMKALGY----YAVVTGRGRKDDSIDAIRQYEEDFFKNS--KLFHRRGVIMPHQV-- 550
            ::||.:  ..||.|.    .|:..|...:........|..|:....|  |....:..|...|:
Human   287 EVLSAR--KQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILA 349

  Fly   551 TSRNL----SLAVSDRFWKMVRETIEQQADA--FKATRFNLET-EWKNNFPRLRESGRDELFDKA 608
            |.:|:    :||..|:....|.|. |.|.|.  |...:.||.| :.|.....:.|    |:.:|.
Human   350 TVKNIMDSVNLAAEDKRHYSVEER-EDQIDRLDFIRNQMNLLTLDVKKKIKEVTE----EVANKV 409

  Fly   609 KGEILDEVVTLSQI---------------------SAKKWDDALSTKLWEKLSNYV--------- 643
            ...:.||:..||.:                     ..|..:|.:...|.::.::.|
Human   410 SCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQ 474

  Fly   644 --FESIYLPAAQSGSQNSFNTMVDIK-------------LRQWAEQALPAKSVEAGWEALQQEFI 693
              .|:: .|...:|.|:..:|::..|             ...:.|..:...|:  ||.:|...|:
Human   475 EIIENL-KPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSL--GWSSLVHRFL 536

  Fly   694 SLMERSKKAQD-----HDGIFDQLKS-----------AVVDEAIRRHSWEDKAIDM---LRVIQL 739
            .    .:.||.     .:.||...:|           |..|.|    |.|:..|.:   |..:..
Human   537 G----PRNAQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNA----SQEELMITLVTGLASVTS 593

  Fly   740 NTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVK 804
            .|.....:.....|        .::..||:....|   |:|.         .||
Human   594 RTSMGIIIVGGVIW--------KTIGWKLLSVSLT---MYGA---------LYL----------- 627

  Fly   805 NELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFP-VYRKHFLQQALQRAKDC 868
                                                   |.|.:|.. ...:.|.||.:..|.:
Human   628 ---------------------------------------YERLSWTTHAKERAFKQQFVNYATE- 652

  Fly   869 RKAYYLYTQQGAEC--EISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDEFSD 931
             |...:.:...|.|  ::.......|.|:.|.:.||     |:.:..|..||.|||        |
Human   653 -KLRMIVSSTSANCSHQVKQQIATTFARLCQQVDIT-----QKQLEEEIARLPKEI--------D 703

  Fly   932 DEEK---KGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQE 971
            ..||   ...||..|.|.|..||      :...::|:.|.|:|
Human   704 QLEKIQNNSKLLRNKAVQLENEL------ENFTKQFLPSSNEE 740

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.