DRSC/TRiP Functional Genomics Resources

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Protein Alignment Opa1 and OPA1

DIOPT Version :9

Sequence 1:NP_725369.1 Gene:Opa1 / 36578 FlyBaseID:FBgn0261276 Length:972 Species:Drosophila melanogaster
Sequence 2:NP_570850.2 Gene:OPA1 / 4976 HGNCID:8140 Length:1015 Species:Homo sapiens


Alignment Length:966 Identity:503/966 - (52%)
Similarity:667/966 - (69%) Gaps:69/966 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LAGNPARGWQMPPPSRGY----GMLVVRILRGALKLRYIVLGGAIGGGVSLSKKYEEWKDGLPN- 120
            |...|.|..:..|...||    .....|:....|||||::||.|:|||.:..|.:::|||.:|: 
Human    65 LTNLPLRKLKFSPIKYGYQPRRNFWPARLATRLLKLRYLILGSAVGGGYTAKKTFDQWKDMIPDL 129

  Fly   121 --FKWL-EDAMPQGERWSQFSRNLIEVGSLVKNAIEVDPKLKQLGED------KLSEWRNWFDS- 175
              :||: .|.:.:.:.:..|.:        ::.|:.....|.:|..|      .||..:::|.| 
Human   130 SEYKWIVPDIVWEIDEYIDFEK--------IRKALPSSEDLVKLAPDFDKIVESLSLLKDFFTSG 186

  Fly   176 --RLDDAIEAADY--------------------------QGV---------QIVETKDDLKAKTT 203
              .:.:.|.|:|.                          :|:         ||.|.:::.:   .
Human   187 HKLVSEVIGASDLLLLLGSPEETAFRATDRGSESDKHFRKGLLGELILLQQQIQEHEEEAR---R 248

  Fly   204 VAALGITSDESRKKYEKLQSQVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLIL-KTNKKTT 267
            .|....||...:|:....:.:::.||.|:::.|:|||:.||::||||:|||:  |:| |.:|...
Human   249 AAGQYSTSYAQQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK--LVLQKDDKGIH 311

  Fly   268 AKKIKKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEM 332
            .:|:|||||||||||||.||.||..|...|||||||||||||:|||||||.||:|||||||||||
Human   312 HRKLKKSLIDMYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEM 376

  Fly   333 MTRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTV 397
            |||:||||||:|||:|||.|:||.||:|||||.||..||.::|.||:.:|:.|.|||.|.|::.|
Human   377 MTRSPVKVTLSEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNV 441

  Fly   398 KGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDL 462
            |||||||||||||||:|:|:|..||.|||::|..::|.||.|||||||||||||||||||.||||
Human   442 KGPGLQRMVLVDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDL 506

  Fly   463 VMQCDPLGRRTIFVLTKVDLAEE-LADPDRIRKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIR 526
            |.|.||.|||||||||||||||: :|.|.||::|:.|||||||||||:|||||:|...:||:|||
Human   507 VSQMDPHGRRTIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIR 571

  Fly   527 QYEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKN 591
            :|||:||:||||. :..::..||||:|||||||||.|||||||::|||||:||||||||||||||
Human   572 EYEEEFFQNSKLL-KTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKN 635

  Fly   592 NFPRLRESGRDELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGS 656
            |:|||||..|:|||:|||.||||||::|||::.|.|::.|...|||::|.:|.|:|||||||:.:
Human   636 NYPRLRELDRNELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMN 700

  Fly   657 QNSFNTMVDIKLRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAI 721
            ..:|||.|||||:||.::.||.|:||..||.||:||...| ...|.::||.|||:||.||.:|:|
Human   701 SGTFNTTVDIKLKQWTDKQLPNKAVEVAWETLQEEFSRFM-TEPKGKEHDDIFDKLKEAVKEESI 764

  Fly   722 RRHSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRR 786
            :||.|.|.|.|.|||||.|.||||.:.|||:||:|:.|:|.::.|:|..||..:..|.||...:|
Human   765 KRHKWNDFAEDSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQARLKDTENAIENMVGPDWKKR 829

  Fly   787 ITHWQYLTQDQQKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFP 851
            ..:|:..||:|......||||:|:||.:.:|...|..||:|||||||:...|:||...|:.||..
Human   830 WLYWKNRTQEQCVHNETKNELEKMLKCNEEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQ 894

  Fly   852 VYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREAR 916
            |||:|||:.||.....||:.:|.|.:...:.|:.|:|||||||||:::.||.|.||||:.|.|.|
Human   895 VYRRHFLKTALNHCNLCRRGFYYYQRHFVDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVR 959

  Fly   917 RLDKEIKAVLDEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQEK 972
            ||:|.:|.||::|::|.|||..|||||||.|||:|.|||:|||||:.||.:|:|||
Human   960 RLEKNVKEVLEDFAEDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Opa1NP_725369.1 DLP_1 298..572 CDD:206738 197/274 (72%)
OPA1NP_570850.2 DLP_1 342..616 CDD:206738 197/274 (72%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141201
Domainoid 1 1.000 571 1.000 Domainoid score I227
eggNOG 1 0.900 - - E1_COG0699
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H14618
Inparanoid 1 1.050 942 1.000 Inparanoid score I345
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52400
OrthoDB 1 1.010 - - D202097at33208
OrthoFinder 1 1.000 - - FOG0006841
OrthoInspector 1 1.000 - - oto88871
orthoMCL 1 0.900 - - OOG6_105511
Panther 1 1.100 - - LDO PTHR11566
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3740
SonicParanoid 1 1.000 - - X4932
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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